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Genomic Approaches to the Study of HIV-1 Acquisition

Telenti, Amalio ; McLaren, Paul

In: The Journal of Infectious Diseases, 2010, vol. 202, no. Supplement_3, p. S382-s386

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    Title
    • Genomic Approaches to the Study of HIV-1 Acquisition
    Author
    • Telenti, Amalio. Institute of Microbiology, University Hospital Center, University of Lausanne, Lausanne, Switzerland
    • McLaren, Paul. Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts
    Document Type
    • Postprint
    Language
    • English
    Published in
    • The Journal of Infectious Diseases, 2010, vol. 202, no. Supplement_3, p. S382-s386. The University of Chicago Press
    Other Version
    Classification
    • Health
    OAI-PMH Identifier
    • oai:doc.rero.ch:304039
    Summary
    Host genome studies are increasingly available for the study of infectious disease susceptibility. Current technologies include large-scale genotyping, genome-wide screens such as transcriptome and silencing (silencing RNA) studies, and increasingly, the possibility to sequence complete genomes. These approaches are of interest for the study of individuals who remain uninfected despite documented exposure to human immunodeficiency virus type 1. The main limitation remains the ascertainment of exposure and establishing large cohorts of informative individuals. The pattern of enrichment for CCR5 Δ32 homozygosis should serve as the standard for assessing the extent to which a given cohort (of white subjects) includes a large proportion of exposed uninfected individuals