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Comparative in-vitro activity of fleroxacin and other 6-fluoroquinolones against mycobacteria

Salfinger, Max ; Hohl, Peter ; Kafader, Felicitas M.

In: Journal of Antimicrobial Chemotherapy, 1988, vol. 22, no. Supplement_D, p. 55-63

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    Titre
    • Comparative in-vitro activity of fleroxacin and other 6-fluoroquinolones against mycobacteria
    Auteur
    • Salfinger, Max. Department of Medical Microbiology, University of Zurich, Switzerland
    • Hohl, Peter. Pharma Research Department, F. Hoffmann-La Roche, Switzerland
    • Kafader, Felicitas M.. Department of Medical Microbiology, University of Zurich, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Journal of Antimicrobial Chemotherapy, 1988, vol. 22, no. Supplement_D, p. 55-63. Oxford University Press
    Autre version électronique
    Classification
    • Santé
    Identifiant OAI-PMH
    • oai:doc.rero.ch:303802
    Summary
    The susceptibility of 11 clinical isolates of Mycobacterium tuberculosis, 3 M. kansasii,3 M. xenopi, 2 M.scrofulaceum, 2 M. marinum, 2 M. malmoense to fleroxacin,ciprofloxacin, norfloxacin, rifampicin, isoniazid, ethambutol, and streptomycin was determined by the standard proportion method (Middlebrook 7HlO agar). All M.tuberculosis,M. kansasii, M. xenopi,M. scrofulaceum, M. marinum,and M. malmoense isolates including those resistant to conventional antimycobacterials were inhibited by 0·5 mg/l of fleroxacin and ciprofloxacin, the lowest tested concentration. Fleroxacin and ciprofloxacin along with ofloxacin,pefloxacin, ansamycin, clofazimine and cycloserine were also tested against 14 isolates of the M. avium complex. Nine of 14 strains (64%) of the M. avium complex were found susceptible to 4 mg/l of fleroxacin and a similar percentage to the other quinolones. On the basis of its in-vitro potency and its favourable pharmacokinetic properties fleroxacin appears to be sufficiently active to warrantfurther experimental trials against difficult to treat mycobacteria