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Viral Escape in the Central Nervous System with Multidrug-Resistant Human Immunodeficiency Virus-1

Béguelin, C. ; Vázquez, M. ; Bertschi, M. ; Yerly, S. ; de Jong, D. ; Gutbrod, K. ; Rauch, A. ; Cusini, A.

In: Open Forum Infectious Diseases, 2015, vol. 3, no. 1, p. -

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    Titel
    • Viral Escape in the Central Nervous System with Multidrug-Resistant Human Immunodeficiency Virus-1
    Autor
    • Béguelin, C.. Department of Infectious Diseases, Inselspital, Bern University Hospital, University of Bern
    • Vázquez, M.. Department of Infectious Diseases, Inselspital, Bern University Hospital, University of Bern
    • Bertschi, M.. Department of Neurology, Bern University Hospital and University of Bern
    • Yerly, S.. Laboratory of Virology, Geneva University Hospital
    • de Jong, D.. Department of Neurology, Bern University Hospital and University of Bern
    • Gutbrod, K.. Department of Neurology, Bern University Hospital and University of Bern
    • Rauch, A.. Department of Infectious Diseases, Inselspital, Bern University Hospital, University of Bern
    • Cusini, A.. Department of Infectious Diseases, Inselspital, Bern University Hospital, University of Bern
    Dokumententyp
    • Postprint
    Sprache
    • Englisch
    Veröffentlicht in
    • Open Forum Infectious Diseases, 2015, vol. 3, p. 1. Oxford University Press
    Andere elektronische Ausgabe
    OAI-PMH-ID
    • oai:doc.rero.ch:303752
    Summary
    In this study, we report the case of a patient infected with human immunodeficiency virus (HIV)-1 who developed ataxia and neurocognitive impairment due to viral escape within the central nervous system (CNS) with a multidrug-resistant HIV-1 despite long-term viral suppression in plasma. Antiretroviral therapy optimization with drugs with high CNS penetration led to viral suppression in the CSF, regression of ataxia, and improvement of neurocognitive symptoms