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Circadian glomerular function: from physiology to molecular and therapeutical aspects

Wuerzner, Grégoire ; Firsov, Dmitri ; Bonny, Olivier

In: Nephrology Dialysis Transplantation, 2014, vol. 29, no. 8, p. 1475-1480

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    Titre
    • Circadian glomerular function: from physiology to molecular and therapeutical aspects
    Auteur
    • Wuerzner, Grégoire. Service of Nephrology, Lausanne University Hospital, Lausanne, Switzerland
    • Firsov, Dmitri. Department of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland
    • Bonny, Olivier. Service of Nephrology, Lausanne University Hospital, Lausanne, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Nephrology Dialysis Transplantation, 2014, vol. 29, no. 8, p. 1475-1480. Oxford University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:303519
    Summary
    Life on earth is rhythmic by essence due to day/night alternation, and many biological processes are also cyclic. The kidney has a special role in the organism, controlling electrolytes and water balance, blood pressure, elimination of metabolic waste and xenobiotics and the production of several hormones. The kidney is submitted to changes throughout 24 h with periods of intense activity followed by calmer periods. Filtration, reabsorption and secretion are the three components determining renal function. Here, we review circadian changes related to glomerular function and proteinuria and emphasize the role of the clock in these processes