Fulltext

Comparison of the Antimicrobial Activity of Deactivated Human Macrophages Challenged with Aspergillus fumigatus and Listeria monocytogenes

Meier-Osusky, Ivetta ; Schoedon, Gabriele ; Bläuer, Franziska ; Schneemann, Markus ; Schaffner, Andreas

In: Journal of Infectious Diseases, 1996, vol. 174, no. 3, p. 651-654

Add to personal list
    Title
    • Comparison of the Antimicrobial Activity of Deactivated Human Macrophages Challenged with Aspergillus fumigatus and Listeria monocytogenes
    Author
    • Meier-Osusky, Ivetta. Laboratory for Clinical Mycology, Division of Infectious Diseases, Department of Medicine, University of Zurich Medical School, Switzerland
    • Schoedon, Gabriele. Laboratory for Clinical Mycology, Division of Infectious Diseases, Department of Medicine, University of Zurich Medical School, Switzerland
    • Bläuer, Franziska. Laboratory for Clinical Mycology, Division of Infectious Diseases, Department of Medicine, University of Zurich Medical School, Switzerland
    • Schneemann, Markus. Laboratory for Clinical Mycology, Division of Infectious Diseases, Department of Medicine, University of Zurich Medical School, Switzerland
    • Schaffner, Andreas. Laboratory for Clinical Mycology, Division of Infectious Diseases, Department of Medicine, University of Zurich Medical School, Switzerland
    Document Type
    • Postprint
    Language
    • English
    Published in
    • Journal of Infectious Diseases, 1996, vol. 174, no. 3, p. 651-654. The University of Chicago Press
    Other Version
    Classification
    • Health
    OAI-PMH Identifier
    • oai:doc.rero.ch:303330
    Summary
    The anticonidial activity of human monocytes deactivated by cytokines interleukin (IL)-4 and IL-10 and the hormone dexamethasone was studied and compared with antilisterial activity. Dexamethasone had the largest effect on the anticonidial activity and suppressed germination-inhibiting activity and elimination of ingested spores by macrophages more than the cytokines did. Maximally active concentrations of IL-10 had a similar but significantly smaller deactivating effect. IL-4, in contrast to IL-10 and dexamethasone, did not reduce anticonidial activity. However, IL-4 and IL-10 were equally potent in deactivating human macrophages against Listeria monocytogenes, whereas dexamethasone was significantly less potent in the Listeria model. These observations indicate that all three mediators lessen antimicrobial activity but that this effect depends on the test organism studied and is apparently mediated through regulation of different antimicrobial systems operating against a particular microorganism