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Enteroaggregative Escherichia coli as a Potential Cause of Diarrheal Disease in Adults Infected with Human Immunodeficiency Virus

Wanke, Christine A. ; Mayer, Howard ; Weber, Rainer ; Zbinden, Reinhard ; Watson, D. Ashley ; Acheson, David

In: Journal of Infectious Diseases, 1998, vol. 178, no. 1, p. 185-190

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    Titre
    • Enteroaggregative Escherichia coli as a Potential Cause of Diarrheal Disease in Adults Infected with Human Immunodeficiency Virus
    Auteur
    • Wanke, Christine A.. Department of Medicine, Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Harvard Medical School, and Division of Geographic Medicine, Tufts University School of Medicine, Boston, Massachusetts, Zurich, Switzerland
    • Mayer, Howard. Department of Medicine, Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Harvard Medical School, and Division of Geographic Medicine, Tufts University School of Medicine, Boston, Massachusetts, Zurich, Switzerland
    • Weber, Rainer. Department of Medicine, Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Harvard Medical School, and Division of Geographic Medicine, Tufts University School of Medicine, Boston, Massachusetts, Zurich, Switzerland
    • Zbinden, Reinhard. Department of Medicine, Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Harvard Medical School, and Division of Geographic Medicine, Tufts University School of Medicine, Boston, Massachusetts, Zurich, Switzerland
    • Watson, D. Ashley. Department of Medicine, Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Harvard Medical School, and Division of Geographic Medicine, Tufts University School of Medicine, Boston, Massachusetts, Zurich, Switzerland
    • Acheson, David. Department of Medicine, Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Harvard Medical School, and Division of Geographic Medicine, Tufts University School of Medicine, Boston, Massachusetts, Zurich, Switzerland
    Type de document
    • Postprint
    Langue
    • Inglese
    Publié dans
    • Journal of Infectious Diseases, 1998, vol. 178, no. 1, p. 185-190. The University of Chicago Press
    Autre version électronique
    Classification
    • Santé
    Identifiant OAI-PMH
    • oai:doc.rero.ch:302950
    Summary
    Stools of 68 human immunodeficiency virus (HIV)-infected adults with diarrhea and 60 without diarrhea were examined for enteroaggregative Escherichia coli (EAggEc) by HeLa cell adherence assay. EAggEc were present in stools of 30 patients with and 18 without diarrhea (P = .05). CD4 cell counts of patients with EAggEc and diarrhea were significantly lower than those of patients with EAggEc without diarrhea (P = .02). There was no difference in the mean duration of diarrheal symptoms or in the number of stools per day between patients with EAggEc and those without. None of the EAggEc strains were positive by polymerase chain reaction for adherence fimbria, but 11 strains were positive for EAggEc heat-stable toxin EAST/1. Of the EAggEc strains, 51% were resistant to trimethoprim-sulfamethoxazole and 65% were resistant to ampicillin. EAggEc may be a pathogen in HIV-infected patients with diarrhea; HIV-infected patients with EAggEc appear to be more symptomatic when HIV disease is more advanced