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Patterns of Proinflammatory Cytokines and Inhibitors during Typhoid Fever

Keuter, Monique ; Dharmana, Edi ; Gasem, M. Hussein ; van der Ven-Jongekrijg, Johanna ; Djokomoeljanto, Robert ; Dolmans, Wil M. V. ; Demacker, Pierre ; Sauerwein, Robert ; Gallati, Harald ; van der Meer, Jos W. M.

In: Journal of Infectious Diseases, 1994, vol. 169, no. 6, p. 1306-1311

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    Title
    • Patterns of Proinflammatory Cytokines and Inhibitors during Typhoid Fever
    Author
    • Keuter, Monique. University Hospital, Nijmegen, Netherlands, Semarang, Indonesia, Basel, Switzerland
    • Dharmana, Edi. University Hospital, Nijmegen, Netherlands, Semarang, Indonesia, Basel, Switzerland
    • Gasem, M. Hussein. University Hospital, Nijmegen, Netherlands, Semarang, Indonesia, Basel, Switzerland
    • van der Ven-Jongekrijg, Johanna. University Hospital, Nijmegen, Netherlands, Semarang, Indonesia, Basel, Switzerland
    • Djokomoeljanto, Robert. University Hospital, Nijmegen, Netherlands, Semarang, Indonesia, Basel, Switzerland
    • Dolmans, Wil M. V.. University Hospital, Nijmegen, Netherlands, Semarang, Indonesia, Basel, Switzerland
    • Demacker, Pierre. University Hospital, Nijmegen, Netherlands, Semarang, Indonesia, Basel, Switzerland
    • Sauerwein, Robert. University Hospital, Nijmegen, Netherlands, Semarang, Indonesia, Basel, Switzerland
    • Gallati, Harald. University Hospital, Nijmegen, Netherlands, Semarang, Indonesia, Basel, Switzerland
    • van der Meer, Jos W. M.. University Hospital, Nijmegen, Netherlands, Semarang, Indonesia, Basel, Switzerland
    Document Type
    • Postprint
    Language
    • English
    Published in
    • Journal of Infectious Diseases, 1994, vol. 169, no. 6, p. 1306-1311. The University of Chicago Press
    Other Version
    Classification
    • Health
    OAI-PMH Identifier
    • oai:doc.rero.ch:302823
    Summary
    Cytokines and inhibitors in plasma were measured in 44 patients with typhoid fever. Ex vivo production of the cytokines was analyzed in a whole blood culture system with and without lipopolysaccharide (LPS). Acute phase circulating concentrations of cytokines (±SD) were as follows: interleukin (IL)-Iβ, <140 pg/mL; tumor necrosis factor-α (TNFa), 130 ± 50 pg/mL; IL-6, 96 ± 131 pg/mL; and IL-8, 278 ± 293 pg/mL. Circulating inhibitors were elevated in the acute phase: IL-1 receptor antagonist (IL-1RA) was 2304 ± 1427 pg/mL and soluble TNF receptors 55 and 75 were 4973 ± 2644 pg/mL and 22,865 ± 15,143 pg/mL, respectively. LPS-stimulated production of cytokines was lower during the acute phase than during convalescence (mean values: IL-Iβ, 2547 vs. 6576 pg/mL; TNFα, 2609 vs. 6338 pg/mL; IL-6, 2416 vs. 7713 pg/mL), LPS-stimulated production of IL-1RA was higher in the acute than during the convalescent phase (5608 vs. 3977 pg/mL). Inhibited production of cytokines during the acute phase may bedue to a switch from a proinflammatory to an antiinflammatory mode