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Treating Progressive Multifocal Leukoencephalopathy With Interleukin 7 and Vaccination With JC Virus Capsid Protein VP1

Sospedra, Mireia ; Schippling, Sven ; Yousef, Sara ; Jelcic, Ilijas ; Bofill-Mas, Silvia ; Planas, Raquel ; Stellmann, Jan-Patrick ; Demina, Viktoria ; Cinque, Paola ; Garcea, Robert ; Croughs, Therese ; Girones, Rosina ; Martin, Roland

In: Clinical Infectious Diseases, 2014, vol. 59, no. 11, p. 1588-1592

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    Titre
    • Treating Progressive Multifocal Leukoencephalopathy With Interleukin 7 and Vaccination With JC Virus Capsid Protein VP1
    Auteur
    • Sospedra, Mireia. Institute for Neuroimmunology and Clinical MS Research, Center for Molecular Neurobiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
    • Schippling, Sven. Institute for Neuroimmunology and Clinical MS Research, Center for Molecular Neurobiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
    • Yousef, Sara. Institute for Neuroimmunology and Clinical MS Research, Center for Molecular Neurobiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
    • Jelcic, Ilijas. Neuroimmunology and Multiple Sclerosis Research, Department of Neurology, University of Zurich, Switzerland
    • Bofill-Mas, Silvia. Department of Microbiology, Faculty of Biology, University of Barcelona, Spain
    • Planas, Raquel. Institute for Neuroimmunology and Clinical MS Research, Center for Molecular Neurobiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
    • Stellmann, Jan-Patrick. Institute for Neuroimmunology and Clinical MS Research, Center for Molecular Neurobiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
    • Demina, Viktoria. Life Science Inkubator, Bonn, Germany
    • Cinque, Paola. Department of Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy
    • Garcea, Robert. Department of Molecular, Cellular and Developmental Biology, University of Colorado Boulder
    • Croughs, Therese. Cytheris S.A., Issy Les Moulineaux, France
    • Girones, Rosina. Department of Microbiology, Faculty of Biology, University of Barcelona, Spain
    • Martin, Roland. Institute for Neuroimmunology and Clinical MS Research, Center for Molecular Neurobiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
    Type de document
    • Postprint
    Langue
    • Inglese
    Publié dans
    • Clinical Infectious Diseases, 2014, vol. 59, no. 11, p. 1588-1592. Oxford University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:302399
    Summary
    Progressive multifocal leukoencephalopathy is a currently untreatable infection of the brain. Here, we demonstrate in 2 patients that treatment with interleukin 7, JC polyomavirus (JCV) capsid protein VP1, and a Toll-like receptor 7 agonist used as adjuvant, was well tolerated, and showed a very favorable safety profile and unexpected efficacy that warrant further investigation