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Progressive decline of decision-making performances during multiple sclerosis

SIMIONI, SAMANTA ; RUFFIEUX, CHRISTIANE ; KLEEBERG, JOERG ; BRUGGIMANN, LAURE ; DU PASQUIER, RENAUD A. ; ANNONI, JEAN-MARIE ; SCHLUEP, MYRIAM

In: Journal of the International Neuropsychological Society, 2009, vol. 15, no. 2, p. 291-295

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    Titre
    • Progressive decline of decision-making performances during multiple sclerosis
    Auteur
    • SIMIONI, SAMANTA. Department of Neurology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland
    • RUFFIEUX, CHRISTIANE. Department of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland
    • KLEEBERG, JOERG. Department of Neurology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland
    • BRUGGIMANN, LAURE. Department of Neurology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland
    • DU PASQUIER, RENAUD A.. Department of Neurology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland
    • ANNONI, JEAN-MARIE. Department of Neurology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland
    • SCHLUEP, MYRIAM. Department of Neurology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Journal of the International Neuropsychological Society, 2009, vol. 15, no. 2, p. 291-295. Cambridge University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:302374
    Summary
    The purpose of this study was to evaluate longitudinally, using the Iowa Gambling Task (IGT), the dynamics of decision-making capacity at a two-year interval (median: 2.1 years) in a group of patients with multiple sclerosis (MS) (n = 70) and minor neurological disability [Expanded Disability Status Scale (EDSS) ≤ 2.5 at baseline]. Cognition (memory, executive functions, attention), behavior, handicap, and perceived health status were also investigated. Standardized change scores [(score at retest-score at baseline)/standard deviation of baseline score] were computed. Results showed that IGT performances decreased from baseline to retest (from 0.3, SD = 0.4 to 0.1, SD = 0.3, p = .005). MS patients who worsened in the IGT were more likely to show a decreased perceived health status and emotional well-being (SEP-59; p = .05 for both). Relapsing rate, disability progression, cognitive, and behavioral changes were not associated with decreased IGT performances. In conclusion, decline in decision making can appear as an isolated deficit in MS. (JINS, 2009, 15, 291-295.)