Fulltext

Inflammatory and metabolic responses to high-fat meals with and without dairy products in men

Schmid, Alexandra ; Petry, Nicolai ; Walther, Barbara ; Bütikofer, Ueli ; Luginbühl, Werner ; Gille, Doreen ; Chollet, Magali ; McTernan, Philip G. ; Gijs, Martin A. M. ; Vionnet, Nathalie ; Pralong, François P. ; Laederach, Kurt ; Vergères, Guy

In: British Journal of Nutrition, 2015, vol. 113, no. 12, p. 1853-1861

Ajouter à la liste personnelle
    Titre
    • Inflammatory and metabolic responses to high-fat meals with and without dairy products in men
    Auteur
    • Schmid, Alexandra. Agroscope, Institute for Food Sciences (IFS), Schwarzenburgstrasse 161, 3003 Bern, Switzerland
    • Petry, Nicolai. Agroscope, Institute for Food Sciences (IFS), Schwarzenburgstrasse 161, 3003 Bern, Switzerland
    • Walther, Barbara. Agroscope, Institute for Food Sciences (IFS), Schwarzenburgstrasse 161, 3003 Bern, Switzerland
    • Bütikofer, Ueli. Agroscope, Institute for Food Sciences (IFS), Schwarzenburgstrasse 161, 3003 Bern, Switzerland
    • Luginbühl, Werner. ChemStat, Bern, Switzerland
    • Gille, Doreen. Agroscope, Institute for Food Sciences (IFS), Schwarzenburgstrasse 161, 3003 Bern, Switzerland
    • Chollet, Magali. Agroscope, Institute for Food Sciences (IFS), Schwarzenburgstrasse 161, 3003 Bern, Switzerland
    • McTernan, Philip G.. Division of Translational and Systems Medicine, University of Warwick, Coventry, UK
    • Gijs, Martin A. M.. Laboratory of Microsystems 2, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
    • Vionnet, Nathalie. Service of Endocrinology, Diabetes and Metabolism, University Hospital CHUV, Lausanne, Switzerland
    • Pralong, François P.. Service of Endocrinology, Diabetes and Metabolism, University Hospital CHUV, Lausanne, Switzerland
    • Laederach, Kurt. Department of Visceral Surgery and Medicine, University Hospital Inselspital, Bern, Switzerland
    • Vergères, Guy. Agroscope, Institute for Food Sciences (IFS), Schwarzenburgstrasse 161, 3003 Bern, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • British Journal of Nutrition, 2015, vol. 113, no. 12, p. 1853-1861. Cambridge University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:302103
    Summary
    Postprandial inflammation is an important factor for human health since chronic low-grade inflammation is associated with chronic diseases. Dairy products have a weak but significant anti-inflammatory effect on postprandial inflammation. The objective of the present study was to compare the effect of a high-fat dairy meal (HFD meal), a high-fat non-dairy meal supplemented with milk (HFM meal) and a high-fat non-dairy control meal (HFC meal) on postprandial inflammatory and metabolic responses in healthy men. A cross-over study was conducted in nineteen male subjects. Blood samples were collected before and 1, 2, 4 and 6h after consumption of the test meals. Plasma concentrations of insulin, glucose, total cholesterol, LDL-cholesterol, HDL-cholesterol, TAG and C-reactive protein (CRP) were measured at each time point. IL-6, TNF-α and endotoxin concentrations were assessed at baseline and endpoint (6h). Time-dependent curves of these metabolic parameters were plotted, and the net incremental AUC were found to be significantly higher for TAG and lower for CRP after consumption of the HFM meal compared with the HFD meal; however, the HFM and HFD meals were not different from the HFC meal. Alterations in IL-6, TNF-α and endotoxin concentrations were not significantly different between the test meals. The results suggest that full-fat milk and dairy products (cheese and butter) have no significant impact on the inflammatory response to a high-fat meal