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Oral Abstracts 7: RA ClinicalO37. Long-Term Outcomes of Early RA Patients Initiated with Adalimumab Plus Methotrexate Compared with Methotrexate Alone Following a Targeted Treatment Approach

Fleischmann, Roy ; van Vollenhoven, Ronald F. ; Smolen, Josef ; Emery, Paul ; Florentinus, Stefan ; Rathmann, Suchitrita ; Kupper, Hartmut ; Kavanaugh, Arthur ; Taylor, Peter ; Genovese, Mark ; Keystone, Edward C. ; Drescher, Edit ; Berclaz, Pierre-Yves ; Lee, Chin ; Fidelus-Gort, Rosalind ; Schlichting, Douglas ; Beattie, Scott ; Luchi, Monica ; Macias, William ; Kavanaugh, Arthur ; Emery, Paul ; van Vollenhoven, Ronald F. ; Dikranian, Ara H. ; Alten, Rieke ; Klearman, Micki ; Musselman, David ; Agarwal, Sunil ; Green, Jennifer ; Gabay, Cem ; Weinblatt, Michael E. ; Schiff, Michael H. ; Fleischmann, Roy ; Valente, Robert ; van der Heijde, Desiree ; Citera, Gustavo ; Zhao, Cathy ; Maldonado, Michael A. ; Rakieh, Chadi ; Nam, Jacqueline L. ; Hunt, Laura ; Villeneuve, Edith ; Bissell, Lesley-Anne ; Das, Sudipto ; Conaghan, Philip ; McGonagle, Dennis ; Wakefield, Richard J. ; Emery, Paul ; Wright, Helen L. ; Thomas, Huw B. ; Moots, Robert ; Edwards, Steven W. ; Hamann, Philip ; Heward, James ; McHugh, Neil ; Lindsay, Mark A. ; Haroon, Muhammad ; Giles, Jon T. ; Winchester, Robert ; FitzGerald, Oliver ; Karaderi, Tugce ; Cohen, Carla J. ; Keidel, Sarah ; Appleton, Louise H. ; Macfarlane, Gary J. ; Siebert, Stefan ; Evans, David ; Paul Wordsworth, B. ; Plant, Darren ; Bowes, John ; Orozco, Gisela ; Morgan, Ann W. ; Wilson, Anthony G. ; Isaacs, John ; Barton, Anne ; Williams, Frances M. ; Livshits, Gregory ; Spector, Tim ; MacGregor, Alexander ; Williams, Frances M. ; Scollen, Serena ; Cao, Dandan ; Memari, Yasin ; Hyde, Craig L. ; Zhang, Baohong ; Sidders, Benjamin ; Ziemek, Daniel ; Shi, Yujian ; Harris, Juliette ; Harrow, Ian ; Dougherty, Brian ; Malarstig, Anders ; McEwen, Robert ; Stephens, Joel L. ; Patel, Ketan ; Shin, So-Youn ; Surdulescu, Gabriela ; He, Wen ; Jin, Xin ; McMahon, Stephen B. ; Soranzo, Nicole ; John, Sally ; Wang, Jun ; Spector, Tim D. ; Baker, Jonathan ; Litherland, Gary J. ; Rowan, Andrew D. ; Kite, Kerry A. ; Bayley, Rachel ; Yang, Peiming ; Smith, Jacqueline P. ; Williams, Julie ; Harper, Lorraine ; Kitas, George D. ; Buckley, Christopher ; Young, Stephen P. ; Fitzpatrick, Martin A. ; Young, Stephen P. ; McGettrick, Helen M. ; Filer, Andrew ; Raza, Karim ; Nash, Gerard ; Buckley, Christopher ; Muthana, Munitta ; Davies, Holly ; Khetan, Sachin ; Adeleke, Gbadebo ; Hawtree, Sarah ; Tazzyman, Simon ; Morrow, Fiona ; Ciani, Barbara ; Wilson, Gerry ; Quirke, Anne-Marie ; Lugli, Elena ; Wegner, Natalia ; Charles, Peter ; Hamilton, Bart ; Chowdhury, Muslima ; Ytterberg, Jimmy ; Potempa, Jan ; Fisher, Benjamin ; Thiele, Geoffrey ; Mikuls, Ted ; Venables, Patrick ; Adebajo, Adewale O. ; Kavanaugh, Arthur ; Mease, Philip ; Gomez-Reino, Juan J. ; Wollenhaupt, Jurgen ; Hu, ChiaChi ; Stevens, Randall ; Sieper, Joachim ; van der Heijde, Desiree ; Dougados, Maxime ; Van den Bosch, Filip ; Goupille, Philippe ; Rathmann, Suchitrita S. ; Pangan, Aileen L. ; van der Heijde, Desiree ; Sieper, Joachim ; Maksymowych, Walter P. ; Brown, Matthew A. ; Rathmann, Suchitrita ; Pangan, Aileen L. ; Sieper, Joachim ; van der Heijde, Desiree ; Elewaut, Dirk ; Pangan, Aileen L. ; Anderson, Jaclyn ; Haroon, Muhammad ; Ramasamy, Pathma ; O'Rourke, Michael ; Murphy, Conor ; Fitzgerald, Oliver ; Jani, Meghna ; Moore, Sarah ; Mirjafari, Hoda ; Macphie, Elizabeth ; Chinoy, Hector ; Rao, Chan ; McLoughlin, Yokemei ; Preeti, Shah

In: Rheumatology, 2013, vol. 52, p. i44-i55

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    Titel
    • Oral Abstracts 7: RA ClinicalO37. Long-Term Outcomes of Early RA Patients Initiated with Adalimumab Plus Methotrexate Compared with Methotrexate Alone Following a Targeted Treatment Approach
    Autor
    • Fleischmann, Roy. Rheumatology, University of Texas Southwestern, Dallas, TX, USA, Rheumatology, Karolinska Institute, Stockholm, Sweden, Institute of Rheumatology, Medical University of Vienna and Hietzing Hospital, Vienna, Austria, Musculoskeletal Disease, Leeds Teaching Hospital, Leeds, UK, Rheumatology Medical Affairs, AbbVie, Rungis, France, Data and Statistical Sciences, AbbVie, North Chicago, IL, USA, Immunology Development, AbbVie GmbH and Co. KG, Ludwigshafen, Germany and Rheumatology, Allergy and Immunology, University of California San Diego, La Jolla, CA, USA
    • van Vollenhoven, Ronald F.. Rheumatology, University of Texas Southwestern, Dallas, TX, USA, Rheumatology, Karolinska Institute, Stockholm, Sweden, Institute of Rheumatology, Medical University of Vienna and Hietzing Hospital, Vienna, Austria, Musculoskeletal Disease, Leeds Teaching Hospital, Leeds, UK, Rheumatology Medical Affairs, AbbVie, Rungis, France, Data and Statistical Sciences, AbbVie, North Chicago, IL, USA, Immunology Development, AbbVie GmbH and Co. KG, Ludwigshafen, Germany and Rheumatology, Allergy and Immunology, University of California San Diego, La Jolla, CA, USA
    • Smolen, Josef. Rheumatology, University of Texas Southwestern, Dallas, TX, USA, Rheumatology, Karolinska Institute, Stockholm, Sweden, Institute of Rheumatology, Medical University of Vienna and Hietzing Hospital, Vienna, Austria, Musculoskeletal Disease, Leeds Teaching Hospital, Leeds, UK, Rheumatology Medical Affairs, AbbVie, Rungis, France, Data and Statistical Sciences, AbbVie, North Chicago, IL, USA, Immunology Development, AbbVie GmbH and Co. KG, Ludwigshafen, Germany and Rheumatology, Allergy and Immunology, University of California San Diego, La Jolla, CA, USA
    • Emery, Paul. Rheumatology, University of Texas Southwestern, Dallas, TX, USA, Rheumatology, Karolinska Institute, Stockholm, Sweden, Institute of Rheumatology, Medical University of Vienna and Hietzing Hospital, Vienna, Austria, Musculoskeletal Disease, Leeds Teaching Hospital, Leeds, UK, Rheumatology Medical Affairs, AbbVie, Rungis, France, Data and Statistical Sciences, AbbVie, North Chicago, IL, USA, Immunology Development, AbbVie GmbH and Co. KG, Ludwigshafen, Germany and Rheumatology, Allergy and Immunology, University of California San Diego, La Jolla, CA, USA
    • Florentinus, Stefan. Rheumatology, University of Texas Southwestern, Dallas, TX, USA, Rheumatology, Karolinska Institute, Stockholm, Sweden, Institute of Rheumatology, Medical University of Vienna and Hietzing Hospital, Vienna, Austria, Musculoskeletal Disease, Leeds Teaching Hospital, Leeds, UK, Rheumatology Medical Affairs, AbbVie, Rungis, France, Data and Statistical Sciences, AbbVie, North Chicago, IL, USA, Immunology Development, AbbVie GmbH and Co. KG, Ludwigshafen, Germany and Rheumatology, Allergy and Immunology, University of California San Diego, La Jolla, CA, USA
    • Rathmann, Suchitrita. Rheumatology, University of Texas Southwestern, Dallas, TX, USA, Rheumatology, Karolinska Institute, Stockholm, Sweden, Institute of Rheumatology, Medical University of Vienna and Hietzing Hospital, Vienna, Austria, Musculoskeletal Disease, Leeds Teaching Hospital, Leeds, UK, Rheumatology Medical Affairs, AbbVie, Rungis, France, Data and Statistical Sciences, AbbVie, North Chicago, IL, USA, Immunology Development, AbbVie GmbH and Co. KG, Ludwigshafen, Germany and Rheumatology, Allergy and Immunology, University of California San Diego, La Jolla, CA, USA
    • Kupper, Hartmut. Rheumatology, University of Texas Southwestern, Dallas, TX, USA, Rheumatology, Karolinska Institute, Stockholm, Sweden, Institute of Rheumatology, Medical University of Vienna and Hietzing Hospital, Vienna, Austria, Musculoskeletal Disease, Leeds Teaching Hospital, Leeds, UK, Rheumatology Medical Affairs, AbbVie, Rungis, France, Data and Statistical Sciences, AbbVie, North Chicago, IL, USA, Immunology Development, AbbVie GmbH and Co. KG, Ludwigshafen, Germany and Rheumatology, Allergy and Immunology, University of California San Diego, La Jolla, CA, USA
    • Kavanaugh, Arthur. Rheumatology, University of Texas Southwestern, Dallas, TX, USA, Rheumatology, Karolinska Institute, Stockholm, Sweden, Institute of Rheumatology, Medical University of Vienna and Hietzing Hospital, Vienna, Austria, Musculoskeletal Disease, Leeds Teaching Hospital, Leeds, UK, Rheumatology Medical Affairs, AbbVie, Rungis, France, Data and Statistical Sciences, AbbVie, North Chicago, IL, USA, Immunology Development, AbbVie GmbH and Co. KG, Ludwigshafen, Germany and Rheumatology, Allergy and Immunology, University of California San Diego, La Jolla, CA, USA
    • Taylor, Peter. Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK, School of Medicine, Stanford University, Palo Alto, CA, USA, School of Medicine, University of Toronto, Toronto, ON, Canada, Department of Rheumatology and Physical Rehabilitation, Veszprém Csolnoky Ferenc County Hospital, Veszprém, Hungary, Lilly Research Labs, Eli Lilly and Co., Indianapolis, IN and Incyte Corporation, Wilmington, DE, USA
    • Genovese, Mark. Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK, School of Medicine, Stanford University, Palo Alto, CA, USA, School of Medicine, University of Toronto, Toronto, ON, Canada, Department of Rheumatology and Physical Rehabilitation, Veszprém Csolnoky Ferenc County Hospital, Veszprém, Hungary, Lilly Research Labs, Eli Lilly and Co., Indianapolis, IN and Incyte Corporation, Wilmington, DE, USA
    • Keystone, Edward C.. Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK, School of Medicine, Stanford University, Palo Alto, CA, USA, School of Medicine, University of Toronto, Toronto, ON, Canada, Department of Rheumatology and Physical Rehabilitation, Veszprém Csolnoky Ferenc County Hospital, Veszprém, Hungary, Lilly Research Labs, Eli Lilly and Co., Indianapolis, IN and Incyte Corporation, Wilmington, DE, USA
    • Drescher, Edit. Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK, School of Medicine, Stanford University, Palo Alto, CA, USA, School of Medicine, University of Toronto, Toronto, ON, Canada, Department of Rheumatology and Physical Rehabilitation, Veszprém Csolnoky Ferenc County Hospital, Veszprém, Hungary, Lilly Research Labs, Eli Lilly and Co., Indianapolis, IN and Incyte Corporation, Wilmington, DE, USA
    • Berclaz, Pierre-Yves. Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK, School of Medicine, Stanford University, Palo Alto, CA, USA, School of Medicine, University of Toronto, Toronto, ON, Canada, Department of Rheumatology and Physical Rehabilitation, Veszprém Csolnoky Ferenc County Hospital, Veszprém, Hungary, Lilly Research Labs, Eli Lilly and Co., Indianapolis, IN and Incyte Corporation, Wilmington, DE, USA
    • Lee, Chin. Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK, School of Medicine, Stanford University, Palo Alto, CA, USA, School of Medicine, University of Toronto, Toronto, ON, Canada, Department of Rheumatology and Physical Rehabilitation, Veszprém Csolnoky Ferenc County Hospital, Veszprém, Hungary, Lilly Research Labs, Eli Lilly and Co., Indianapolis, IN and Incyte Corporation, Wilmington, DE, USA
    • Fidelus-Gort, Rosalind. Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK, School of Medicine, Stanford University, Palo Alto, CA, USA, School of Medicine, University of Toronto, Toronto, ON, Canada, Department of Rheumatology and Physical Rehabilitation, Veszprém Csolnoky Ferenc County Hospital, Veszprém, Hungary, Lilly Research Labs, Eli Lilly and Co., Indianapolis, IN and Incyte Corporation, Wilmington, DE, USA
    • Schlichting, Douglas. Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK, School of Medicine, Stanford University, Palo Alto, CA, USA, School of Medicine, University of Toronto, Toronto, ON, Canada, Department of Rheumatology and Physical Rehabilitation, Veszprém Csolnoky Ferenc County Hospital, Veszprém, Hungary, Lilly Research Labs, Eli Lilly and Co., Indianapolis, IN and Incyte Corporation, Wilmington, DE, USA
    • Beattie, Scott. Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK, School of Medicine, Stanford University, Palo Alto, CA, USA, School of Medicine, University of Toronto, Toronto, ON, Canada, Department of Rheumatology and Physical Rehabilitation, Veszprém Csolnoky Ferenc County Hospital, Veszprém, Hungary, Lilly Research Labs, Eli Lilly and Co., Indianapolis, IN and Incyte Corporation, Wilmington, DE, USA
    • Luchi, Monica. Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK, School of Medicine, Stanford University, Palo Alto, CA, USA, School of Medicine, University of Toronto, Toronto, ON, Canada, Department of Rheumatology and Physical Rehabilitation, Veszprém Csolnoky Ferenc County Hospital, Veszprém, Hungary, Lilly Research Labs, Eli Lilly and Co., Indianapolis, IN and Incyte Corporation, Wilmington, DE, USA
    • Macias, William. Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK, School of Medicine, Stanford University, Palo Alto, CA, USA, School of Medicine, University of Toronto, Toronto, ON, Canada, Department of Rheumatology and Physical Rehabilitation, Veszprém Csolnoky Ferenc County Hospital, Veszprém, Hungary, Lilly Research Labs, Eli Lilly and Co., Indianapolis, IN and Incyte Corporation, Wilmington, DE, USA
    • Kavanaugh, Arthur. Rheumatology, UCSD School of Medicine, La Jolla, CA, USA, Rheumatology, University of Leeds, Leeds, UK, Rheumatology, Karolinska Institute, Stockholm, Sweden, Rheumatology, San Diego Arthritis Medical Clinic, San Diego, CA, USA, Rheumatology, Schlosspark Klinik, University Medicine Berlin, Berlin, Germany, Medical, Genentech Inc., San Francisco, CA, USA, Medical, Roche Products Ltd, Welwyn Garden City, UK and Rheumatology, Geneva University Hospitals, Geneva, Switzerland
    • Emery, Paul. Rheumatology, UCSD School of Medicine, La Jolla, CA, USA, Rheumatology, University of Leeds, Leeds, UK, Rheumatology, Karolinska Institute, Stockholm, Sweden, Rheumatology, San Diego Arthritis Medical Clinic, San Diego, CA, USA, Rheumatology, Schlosspark Klinik, University Medicine Berlin, Berlin, Germany, Medical, Genentech Inc., San Francisco, CA, USA, Medical, Roche Products Ltd, Welwyn Garden City, UK and Rheumatology, Geneva University Hospitals, Geneva, Switzerland
    • van Vollenhoven, Ronald F.. Rheumatology, UCSD School of Medicine, La Jolla, CA, USA, Rheumatology, University of Leeds, Leeds, UK, Rheumatology, Karolinska Institute, Stockholm, Sweden, Rheumatology, San Diego Arthritis Medical Clinic, San Diego, CA, USA, Rheumatology, Schlosspark Klinik, University Medicine Berlin, Berlin, Germany, Medical, Genentech Inc., San Francisco, CA, USA, Medical, Roche Products Ltd, Welwyn Garden City, UK and Rheumatology, Geneva University Hospitals, Geneva, Switzerland
    • Dikranian, Ara H.. Rheumatology, UCSD School of Medicine, La Jolla, CA, USA, Rheumatology, University of Leeds, Leeds, UK, Rheumatology, Karolinska Institute, Stockholm, Sweden, Rheumatology, San Diego Arthritis Medical Clinic, San Diego, CA, USA, Rheumatology, Schlosspark Klinik, University Medicine Berlin, Berlin, Germany, Medical, Genentech Inc., San Francisco, CA, USA, Medical, Roche Products Ltd, Welwyn Garden City, UK and Rheumatology, Geneva University Hospitals, Geneva, Switzerland
    • Alten, Rieke. Rheumatology, UCSD School of Medicine, La Jolla, CA, USA, Rheumatology, University of Leeds, Leeds, UK, Rheumatology, Karolinska Institute, Stockholm, Sweden, Rheumatology, San Diego Arthritis Medical Clinic, San Diego, CA, USA, Rheumatology, Schlosspark Klinik, University Medicine Berlin, Berlin, Germany, Medical, Genentech Inc., San Francisco, CA, USA, Medical, Roche Products Ltd, Welwyn Garden City, UK and Rheumatology, Geneva University Hospitals, Geneva, Switzerland
    • Klearman, Micki. Rheumatology, UCSD School of Medicine, La Jolla, CA, USA, Rheumatology, University of Leeds, Leeds, UK, Rheumatology, Karolinska Institute, Stockholm, Sweden, Rheumatology, San Diego Arthritis Medical Clinic, San Diego, CA, USA, Rheumatology, Schlosspark Klinik, University Medicine Berlin, Berlin, Germany, Medical, Genentech Inc., San Francisco, CA, USA, Medical, Roche Products Ltd, Welwyn Garden City, UK and Rheumatology, Geneva University Hospitals, Geneva, Switzerland
    • Musselman, David. Rheumatology, UCSD School of Medicine, La Jolla, CA, USA, Rheumatology, University of Leeds, Leeds, UK, Rheumatology, Karolinska Institute, Stockholm, Sweden, Rheumatology, San Diego Arthritis Medical Clinic, San Diego, CA, USA, Rheumatology, Schlosspark Klinik, University Medicine Berlin, Berlin, Germany, Medical, Genentech Inc., San Francisco, CA, USA, Medical, Roche Products Ltd, Welwyn Garden City, UK and Rheumatology, Geneva University Hospitals, Geneva, Switzerland
    • Agarwal, Sunil. Rheumatology, UCSD School of Medicine, La Jolla, CA, USA, Rheumatology, University of Leeds, Leeds, UK, Rheumatology, Karolinska Institute, Stockholm, Sweden, Rheumatology, San Diego Arthritis Medical Clinic, San Diego, CA, USA, Rheumatology, Schlosspark Klinik, University Medicine Berlin, Berlin, Germany, Medical, Genentech Inc., San Francisco, CA, USA, Medical, Roche Products Ltd, Welwyn Garden City, UK and Rheumatology, Geneva University Hospitals, Geneva, Switzerland
    • Green, Jennifer. Rheumatology, UCSD School of Medicine, La Jolla, CA, USA, Rheumatology, University of Leeds, Leeds, UK, Rheumatology, Karolinska Institute, Stockholm, Sweden, Rheumatology, San Diego Arthritis Medical Clinic, San Diego, CA, USA, Rheumatology, Schlosspark Klinik, University Medicine Berlin, Berlin, Germany, Medical, Genentech Inc., San Francisco, CA, USA, Medical, Roche Products Ltd, Welwyn Garden City, UK and Rheumatology, Geneva University Hospitals, Geneva, Switzerland
    • Gabay, Cem. Rheumatology, UCSD School of Medicine, La Jolla, CA, USA, Rheumatology, University of Leeds, Leeds, UK, Rheumatology, Karolinska Institute, Stockholm, Sweden, Rheumatology, San Diego Arthritis Medical Clinic, San Diego, CA, USA, Rheumatology, Schlosspark Klinik, University Medicine Berlin, Berlin, Germany, Medical, Genentech Inc., San Francisco, CA, USA, Medical, Roche Products Ltd, Welwyn Garden City, UK and Rheumatology, Geneva University Hospitals, Geneva, Switzerland
    • Weinblatt, Michael E.. Rheumatology and Immunology, Brigham and Women's Hospital, Boston, MA, Rheumatology Division, University of Colorado, Denver, CO, Department of Internal Medicine, University of Texas Southwestern Medical Centre, Dallas, TX, Rheumatology, Arthritis Centre of Nebraska, Lincoln, NE, USA, Department of Rheumatology, Leiden University Medical Centre, Leiden, Netherlands, Section of Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, Global Biometric Sciences, Bristol-Myers Squibb, Princeton, NJ and Medical Affairs, Bristol-Myers Squibb, Princeton, NJ, USA
    • Schiff, Michael H.. Rheumatology and Immunology, Brigham and Women's Hospital, Boston, MA, Rheumatology Division, University of Colorado, Denver, CO, Department of Internal Medicine, University of Texas Southwestern Medical Centre, Dallas, TX, Rheumatology, Arthritis Centre of Nebraska, Lincoln, NE, USA, Department of Rheumatology, Leiden University Medical Centre, Leiden, Netherlands, Section of Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, Global Biometric Sciences, Bristol-Myers Squibb, Princeton, NJ and Medical Affairs, Bristol-Myers Squibb, Princeton, NJ, USA
    • Fleischmann, Roy. Rheumatology and Immunology, Brigham and Women's Hospital, Boston, MA, Rheumatology Division, University of Colorado, Denver, CO, Department of Internal Medicine, University of Texas Southwestern Medical Centre, Dallas, TX, Rheumatology, Arthritis Centre of Nebraska, Lincoln, NE, USA, Department of Rheumatology, Leiden University Medical Centre, Leiden, Netherlands, Section of Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, Global Biometric Sciences, Bristol-Myers Squibb, Princeton, NJ and Medical Affairs, Bristol-Myers Squibb, Princeton, NJ, USA
    • Valente, Robert. Rheumatology and Immunology, Brigham and Women's Hospital, Boston, MA, Rheumatology Division, University of Colorado, Denver, CO, Department of Internal Medicine, University of Texas Southwestern Medical Centre, Dallas, TX, Rheumatology, Arthritis Centre of Nebraska, Lincoln, NE, USA, Department of Rheumatology, Leiden University Medical Centre, Leiden, Netherlands, Section of Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, Global Biometric Sciences, Bristol-Myers Squibb, Princeton, NJ and Medical Affairs, Bristol-Myers Squibb, Princeton, NJ, USA
    • van der Heijde, Desiree. Rheumatology and Immunology, Brigham and Women's Hospital, Boston, MA, Rheumatology Division, University of Colorado, Denver, CO, Department of Internal Medicine, University of Texas Southwestern Medical Centre, Dallas, TX, Rheumatology, Arthritis Centre of Nebraska, Lincoln, NE, USA, Department of Rheumatology, Leiden University Medical Centre, Leiden, Netherlands, Section of Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, Global Biometric Sciences, Bristol-Myers Squibb, Princeton, NJ and Medical Affairs, Bristol-Myers Squibb, Princeton, NJ, USA
    • Citera, Gustavo. Rheumatology and Immunology, Brigham and Women's Hospital, Boston, MA, Rheumatology Division, University of Colorado, Denver, CO, Department of Internal Medicine, University of Texas Southwestern Medical Centre, Dallas, TX, Rheumatology, Arthritis Centre of Nebraska, Lincoln, NE, USA, Department of Rheumatology, Leiden University Medical Centre, Leiden, Netherlands, Section of Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, Global Biometric Sciences, Bristol-Myers Squibb, Princeton, NJ and Medical Affairs, Bristol-Myers Squibb, Princeton, NJ, USA
    • Zhao, Cathy. Rheumatology and Immunology, Brigham and Women's Hospital, Boston, MA, Rheumatology Division, University of Colorado, Denver, CO, Department of Internal Medicine, University of Texas Southwestern Medical Centre, Dallas, TX, Rheumatology, Arthritis Centre of Nebraska, Lincoln, NE, USA, Department of Rheumatology, Leiden University Medical Centre, Leiden, Netherlands, Section of Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, Global Biometric Sciences, Bristol-Myers Squibb, Princeton, NJ and Medical Affairs, Bristol-Myers Squibb, Princeton, NJ, USA
    • Maldonado, Michael A.. Rheumatology and Immunology, Brigham and Women's Hospital, Boston, MA, Rheumatology Division, University of Colorado, Denver, CO, Department of Internal Medicine, University of Texas Southwestern Medical Centre, Dallas, TX, Rheumatology, Arthritis Centre of Nebraska, Lincoln, NE, USA, Department of Rheumatology, Leiden University Medical Centre, Leiden, Netherlands, Section of Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, Global Biometric Sciences, Bristol-Myers Squibb, Princeton, NJ and Medical Affairs, Bristol-Myers Squibb, Princeton, NJ, USA
    • Rakieh, Chadi. Division of Rheumatic and Musculoskeletal Disease, LIMM, University of Leeds, Leeds, UK
    • Nam, Jacqueline L.. Division of Rheumatic and Musculoskeletal Disease, LIMM, University of Leeds, Leeds, UK
    • Hunt, Laura. Division of Rheumatic and Musculoskeletal Disease, LIMM, University of Leeds, Leeds, UK
    • Villeneuve, Edith. Division of Rheumatic and Musculoskeletal Disease, LIMM, University of Leeds, Leeds, UK
    • Bissell, Lesley-Anne. Division of Rheumatic and Musculoskeletal Disease, LIMM, University of Leeds, Leeds, UK
    • Das, Sudipto. Division of Rheumatic and Musculoskeletal Disease, LIMM, University of Leeds, Leeds, UK
    • Conaghan, Philip. Division of Rheumatic and Musculoskeletal Disease, LIMM, University of Leeds, Leeds, UK
    • McGonagle, Dennis. Division of Rheumatic and Musculoskeletal Disease, LIMM, University of Leeds, Leeds, UK
    • Wakefield, Richard J.. Division of Rheumatic and Musculoskeletal Disease, LIMM, University of Leeds, Leeds, UK
    • Emery, Paul. Division of Rheumatic and Musculoskeletal Disease, LIMM, University of Leeds, Leeds, UK
    • Wright, Helen L.. Institute of Integrative Biology, University of Liverpool, Liverpool and Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK
    • Thomas, Huw B.. Institute of Integrative Biology, University of Liverpool, Liverpool and Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK
    • Moots, Robert. Institute of Integrative Biology, University of Liverpool, Liverpool and Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK
    • Edwards, Steven W.. Institute of Integrative Biology, University of Liverpool, Liverpool and Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK
    • Hamann, Philip. Department of Rheumatology, Royal National Hospital for Rheumatic Diseases, Bath and Department of Pharmacy and Pharmacology, University of Bath, Bath, UK
    • Heward, James. Department of Rheumatology, Royal National Hospital for Rheumatic Diseases, Bath and Department of Pharmacy and Pharmacology, University of Bath, Bath, UK
    • McHugh, Neil. Department of Rheumatology, Royal National Hospital for Rheumatic Diseases, Bath and Department of Pharmacy and Pharmacology, University of Bath, Bath, UK
    • Lindsay, Mark A.. Department of Rheumatology, Royal National Hospital for Rheumatic Diseases, Bath and Department of Pharmacy and Pharmacology, University of Bath, Bath, UK
    • Haroon, Muhammad. Department of Rheumatology, St Vincent's University Hospital, Dublin, Ireland, Rheumatology, Columbia University, New York, NY and Rheumatology, Columbia University Medical Centre, New York, NY, USA
    • Giles, Jon T.. Department of Rheumatology, St Vincent's University Hospital, Dublin, Ireland, Rheumatology, Columbia University, New York, NY and Rheumatology, Columbia University Medical Centre, New York, NY, USA
    • Winchester, Robert. Department of Rheumatology, St Vincent's University Hospital, Dublin, Ireland, Rheumatology, Columbia University, New York, NY and Rheumatology, Columbia University Medical Centre, New York, NY, USA
    • FitzGerald, Oliver. Department of Rheumatology, St Vincent's University Hospital, Dublin, Ireland, Rheumatology, Columbia University, New York, NY and Rheumatology, Columbia University Medical Centre, New York, NY, USA
    • Karaderi, Tugce. Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, Epidemiology Group, Institute of Applied Health Sciences, School of Medicine and Dentistry, University of Aberdeen, Aberdeen, Rheumatology Department, Swansea University, Swansea, MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, NIHR Comprehensive Biomedical Research Centre and Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, University of Oxford, Oxford, UK
    • Cohen, Carla J.. Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, Epidemiology Group, Institute of Applied Health Sciences, School of Medicine and Dentistry, University of Aberdeen, Aberdeen, Rheumatology Department, Swansea University, Swansea, MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, NIHR Comprehensive Biomedical Research Centre and Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, University of Oxford, Oxford, UK
    • Keidel, Sarah. Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, Epidemiology Group, Institute of Applied Health Sciences, School of Medicine and Dentistry, University of Aberdeen, Aberdeen, Rheumatology Department, Swansea University, Swansea, MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, NIHR Comprehensive Biomedical Research Centre and Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, University of Oxford, Oxford, UK
    • Appleton, Louise H.. Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, Epidemiology Group, Institute of Applied Health Sciences, School of Medicine and Dentistry, University of Aberdeen, Aberdeen, Rheumatology Department, Swansea University, Swansea, MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, NIHR Comprehensive Biomedical Research Centre and Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, University of Oxford, Oxford, UK
    • Macfarlane, Gary J.. Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, Epidemiology Group, Institute of Applied Health Sciences, School of Medicine and Dentistry, University of Aberdeen, Aberdeen, Rheumatology Department, Swansea University, Swansea, MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, NIHR Comprehensive Biomedical Research Centre and Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, University of Oxford, Oxford, UK
    • Siebert, Stefan. Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, Epidemiology Group, Institute of Applied Health Sciences, School of Medicine and Dentistry, University of Aberdeen, Aberdeen, Rheumatology Department, Swansea University, Swansea, MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, NIHR Comprehensive Biomedical Research Centre and Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, University of Oxford, Oxford, UK
    • Evans, David. Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, Epidemiology Group, Institute of Applied Health Sciences, School of Medicine and Dentistry, University of Aberdeen, Aberdeen, Rheumatology Department, Swansea University, Swansea, MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, NIHR Comprehensive Biomedical Research Centre and Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, University of Oxford, Oxford, UK
    • Paul Wordsworth, B.. Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, Epidemiology Group, Institute of Applied Health Sciences, School of Medicine and Dentistry, University of Aberdeen, Aberdeen, Rheumatology Department, Swansea University, Swansea, MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, NIHR Comprehensive Biomedical Research Centre and Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, University of Oxford, Oxford, UK
    • Plant, Darren. Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, NIHR—Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Molecular Medicine, University of Leeds, Leeds, Academic Unit of Rheumatology, Department of Infection and Immunity, University of Sheffield, Sheffield, Musculoskeletal Research Group, University of Newcastle and Newcastle Hospitals NHS Foundation Trust, Newcastle and Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate, UK
    • Bowes, John. Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, NIHR—Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Molecular Medicine, University of Leeds, Leeds, Academic Unit of Rheumatology, Department of Infection and Immunity, University of Sheffield, Sheffield, Musculoskeletal Research Group, University of Newcastle and Newcastle Hospitals NHS Foundation Trust, Newcastle and Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate, UK
    • Orozco, Gisela. Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, NIHR—Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Molecular Medicine, University of Leeds, Leeds, Academic Unit of Rheumatology, Department of Infection and Immunity, University of Sheffield, Sheffield, Musculoskeletal Research Group, University of Newcastle and Newcastle Hospitals NHS Foundation Trust, Newcastle and Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate, UK
    • Morgan, Ann W.. Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, NIHR—Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Molecular Medicine, University of Leeds, Leeds, Academic Unit of Rheumatology, Department of Infection and Immunity, University of Sheffield, Sheffield, Musculoskeletal Research Group, University of Newcastle and Newcastle Hospitals NHS Foundation Trust, Newcastle and Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate, UK
    • Wilson, Anthony G.. Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, NIHR—Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Molecular Medicine, University of Leeds, Leeds, Academic Unit of Rheumatology, Department of Infection and Immunity, University of Sheffield, Sheffield, Musculoskeletal Research Group, University of Newcastle and Newcastle Hospitals NHS Foundation Trust, Newcastle and Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate, UK
    • Isaacs, John. Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, NIHR—Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Molecular Medicine, University of Leeds, Leeds, Academic Unit of Rheumatology, Department of Infection and Immunity, University of Sheffield, Sheffield, Musculoskeletal Research Group, University of Newcastle and Newcastle Hospitals NHS Foundation Trust, Newcastle and Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate, UK
    • Barton, Anne. Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, NIHR—Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Molecular Medicine, University of Leeds, Leeds, Academic Unit of Rheumatology, Department of Infection and Immunity, University of Sheffield, Sheffield, Musculoskeletal Research Group, University of Newcastle and Newcastle Hospitals NHS Foundation Trust, Newcastle and Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate, UK
    • Williams, Frances M.. Twin Research and Genetic Epidemiology, King's College London, London, UK, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel and Norwich Medical School, University of East Anglia, Norwich, UK
    • Livshits, Gregory. Twin Research and Genetic Epidemiology, King's College London, London, UK, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel and Norwich Medical School, University of East Anglia, Norwich, UK
    • Spector, Tim. Twin Research and Genetic Epidemiology, King's College London, London, UK, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel and Norwich Medical School, University of East Anglia, Norwich, UK
    • MacGregor, Alexander. Twin Research and Genetic Epidemiology, King's College London, London, UK, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel and Norwich Medical School, University of East Anglia, Norwich, UK
    • Williams, Frances M.. Twin Research and Genetic Epidemiology, King's College London, London, Neusentis, Pfizer Ltd, Cambridge, UK, BGI-Shenzhen, Beijing Genomics Institute, Shenzhen, China, Wellcome Trust Sanger Institute, Hinxton, UK, Pfizer Research Laboratories, Pfizer Inc, Groton, CT, USA and Wolfson CARD, King's College London, London, UK
    • Scollen, Serena. Twin Research and Genetic Epidemiology, King's College London, London, Neusentis, Pfizer Ltd, Cambridge, UK, BGI-Shenzhen, Beijing Genomics Institute, Shenzhen, China, Wellcome Trust Sanger Institute, Hinxton, UK, Pfizer Research Laboratories, Pfizer Inc, Groton, CT, USA and Wolfson CARD, King's College London, London, UK
    • Cao, Dandan. Twin Research and Genetic Epidemiology, King's College London, London, Neusentis, Pfizer Ltd, Cambridge, UK, BGI-Shenzhen, Beijing Genomics Institute, Shenzhen, China, Wellcome Trust Sanger Institute, Hinxton, UK, Pfizer Research Laboratories, Pfizer Inc, Groton, CT, USA and Wolfson CARD, King's College London, London, UK
    • Memari, Yasin. Twin Research and Genetic Epidemiology, King's College London, London, Neusentis, Pfizer Ltd, Cambridge, UK, BGI-Shenzhen, Beijing Genomics Institute, Shenzhen, China, Wellcome Trust Sanger Institute, Hinxton, UK, Pfizer Research Laboratories, Pfizer Inc, Groton, CT, USA and Wolfson CARD, King's College London, London, UK
    • Hyde, Craig L.. Twin Research and Genetic Epidemiology, King's College London, London, Neusentis, Pfizer Ltd, Cambridge, UK, BGI-Shenzhen, Beijing Genomics Institute, Shenzhen, China, Wellcome Trust Sanger Institute, Hinxton, UK, Pfizer Research Laboratories, Pfizer Inc, Groton, CT, USA and Wolfson CARD, King's College London, London, UK
    • Zhang, Baohong. Twin Research and Genetic Epidemiology, King's College London, London, Neusentis, Pfizer Ltd, Cambridge, UK, BGI-Shenzhen, Beijing Genomics Institute, Shenzhen, China, Wellcome Trust Sanger Institute, Hinxton, UK, Pfizer Research Laboratories, Pfizer Inc, Groton, CT, USA and Wolfson CARD, King's College London, London, UK
    • Sidders, Benjamin. Twin Research and Genetic Epidemiology, King's College London, London, Neusentis, Pfizer Ltd, Cambridge, UK, BGI-Shenzhen, Beijing Genomics Institute, Shenzhen, China, Wellcome Trust Sanger Institute, Hinxton, UK, Pfizer Research Laboratories, Pfizer Inc, Groton, CT, USA and Wolfson CARD, King's College London, London, UK
    • Ziemek, Daniel. Twin Research and Genetic Epidemiology, King's College London, London, Neusentis, Pfizer Ltd, Cambridge, UK, BGI-Shenzhen, Beijing Genomics Institute, Shenzhen, China, Wellcome Trust Sanger Institute, Hinxton, UK, Pfizer Research Laboratories, Pfizer Inc, Groton, CT, USA and Wolfson CARD, King's College London, London, UK
    • Shi, Yujian. Twin Research and Genetic Epidemiology, King's College London, London, Neusentis, Pfizer Ltd, Cambridge, UK, BGI-Shenzhen, Beijing Genomics Institute, Shenzhen, China, Wellcome Trust Sanger Institute, Hinxton, UK, Pfizer Research Laboratories, Pfizer Inc, Groton, CT, USA and Wolfson CARD, King's College London, London, UK
    • Harris, Juliette. Twin Research and Genetic Epidemiology, King's College London, London, Neusentis, Pfizer Ltd, Cambridge, UK, BGI-Shenzhen, Beijing Genomics Institute, Shenzhen, China, Wellcome Trust Sanger Institute, Hinxton, UK, Pfizer Research Laboratories, Pfizer Inc, Groton, CT, USA and Wolfson CARD, King's College London, London, UK
    • Harrow, Ian. Twin Research and Genetic Epidemiology, King's College London, London, Neusentis, Pfizer Ltd, Cambridge, UK, BGI-Shenzhen, Beijing Genomics Institute, Shenzhen, China, Wellcome Trust Sanger Institute, Hinxton, UK, Pfizer Research Laboratories, Pfizer Inc, Groton, CT, USA and Wolfson CARD, King's College London, London, UK
    • Dougherty, Brian. Twin Research and Genetic Epidemiology, King's College London, London, Neusentis, Pfizer Ltd, Cambridge, UK, BGI-Shenzhen, Beijing Genomics Institute, Shenzhen, China, Wellcome Trust Sanger Institute, Hinxton, UK, Pfizer Research Laboratories, Pfizer Inc, Groton, CT, USA and Wolfson CARD, King's College London, London, UK
    • Malarstig, Anders. Twin Research and Genetic Epidemiology, King's College London, London, Neusentis, Pfizer Ltd, Cambridge, UK, BGI-Shenzhen, Beijing Genomics Institute, Shenzhen, China, Wellcome Trust Sanger Institute, Hinxton, UK, Pfizer Research Laboratories, Pfizer Inc, Groton, CT, USA and Wolfson CARD, King's College London, London, UK
    • McEwen, Robert. Twin Research and Genetic Epidemiology, King's College London, London, Neusentis, Pfizer Ltd, Cambridge, UK, BGI-Shenzhen, Beijing Genomics Institute, Shenzhen, China, Wellcome Trust Sanger Institute, Hinxton, UK, Pfizer Research Laboratories, Pfizer Inc, Groton, CT, USA and Wolfson CARD, King's College London, London, UK
    • Stephens, Joel L.. Twin Research and Genetic Epidemiology, King's College London, London, Neusentis, Pfizer Ltd, Cambridge, UK, BGI-Shenzhen, Beijing Genomics Institute, Shenzhen, China, Wellcome Trust Sanger Institute, Hinxton, UK, Pfizer Research Laboratories, Pfizer Inc, Groton, CT, USA and Wolfson CARD, King's College London, London, UK
    • Patel, Ketan. Twin Research and Genetic Epidemiology, King's College London, London, Neusentis, Pfizer Ltd, Cambridge, UK, BGI-Shenzhen, Beijing Genomics Institute, Shenzhen, China, Wellcome Trust Sanger Institute, Hinxton, UK, Pfizer Research Laboratories, Pfizer Inc, Groton, CT, USA and Wolfson CARD, King's College London, London, UK
    • Shin, So-Youn. Twin Research and Genetic Epidemiology, King's College London, London, Neusentis, Pfizer Ltd, Cambridge, UK, BGI-Shenzhen, Beijing Genomics Institute, Shenzhen, China, Wellcome Trust Sanger Institute, Hinxton, UK, Pfizer Research Laboratories, Pfizer Inc, Groton, CT, USA and Wolfson CARD, King's College London, London, UK
    • Surdulescu, Gabriela. Twin Research and Genetic Epidemiology, King's College London, London, Neusentis, Pfizer Ltd, Cambridge, UK, BGI-Shenzhen, Beijing Genomics Institute, Shenzhen, China, Wellcome Trust Sanger Institute, Hinxton, UK, Pfizer Research Laboratories, Pfizer Inc, Groton, CT, USA and Wolfson CARD, King's College London, London, UK
    • He, Wen. Twin Research and Genetic Epidemiology, King's College London, London, Neusentis, Pfizer Ltd, Cambridge, UK, BGI-Shenzhen, Beijing Genomics Institute, Shenzhen, China, Wellcome Trust Sanger Institute, Hinxton, UK, Pfizer Research Laboratories, Pfizer Inc, Groton, CT, USA and Wolfson CARD, King's College London, London, UK
    • Jin, Xin. Twin Research and Genetic Epidemiology, King's College London, London, Neusentis, Pfizer Ltd, Cambridge, UK, BGI-Shenzhen, Beijing Genomics Institute, Shenzhen, China, Wellcome Trust Sanger Institute, Hinxton, UK, Pfizer Research Laboratories, Pfizer Inc, Groton, CT, USA and Wolfson CARD, King's College London, London, UK
    • McMahon, Stephen B.. Twin Research and Genetic Epidemiology, King's College London, London, Neusentis, Pfizer Ltd, Cambridge, UK, BGI-Shenzhen, Beijing Genomics Institute, Shenzhen, China, Wellcome Trust Sanger Institute, Hinxton, UK, Pfizer Research Laboratories, Pfizer Inc, Groton, CT, USA and Wolfson CARD, King's College London, London, UK
    • Soranzo, Nicole. Twin Research and Genetic Epidemiology, King's College London, London, Neusentis, Pfizer Ltd, Cambridge, UK, BGI-Shenzhen, Beijing Genomics Institute, Shenzhen, China, Wellcome Trust Sanger Institute, Hinxton, UK, Pfizer Research Laboratories, Pfizer Inc, Groton, CT, USA and Wolfson CARD, King's College London, London, UK
    • John, Sally. Twin Research and Genetic Epidemiology, King's College London, London, Neusentis, Pfizer Ltd, Cambridge, UK, BGI-Shenzhen, Beijing Genomics Institute, Shenzhen, China, Wellcome Trust Sanger Institute, Hinxton, UK, Pfizer Research Laboratories, Pfizer Inc, Groton, CT, USA and Wolfson CARD, King's College London, London, UK
    • Wang, Jun. Twin Research and Genetic Epidemiology, King's College London, London, Neusentis, Pfizer Ltd, Cambridge, UK, BGI-Shenzhen, Beijing Genomics Institute, Shenzhen, China, Wellcome Trust Sanger Institute, Hinxton, UK, Pfizer Research Laboratories, Pfizer Inc, Groton, CT, USA and Wolfson CARD, King's College London, London, UK
    • Spector, Tim D.. Twin Research and Genetic Epidemiology, King's College London, London, Neusentis, Pfizer Ltd, Cambridge, UK, BGI-Shenzhen, Beijing Genomics Institute, Shenzhen, China, Wellcome Trust Sanger Institute, Hinxton, UK, Pfizer Research Laboratories, Pfizer Inc, Groton, CT, USA and Wolfson CARD, King's College London, London, UK
    • Baker, Jonathan. Musculoskeletal Research Group, University of Newcastle, Newcastle, UK
    • Litherland, Gary J.. Musculoskeletal Research Group, University of Newcastle, Newcastle, UK
    • Rowan, Andrew D.. Musculoskeletal Research Group, University of Newcastle, Newcastle, UK
    • Kite, Kerry A.. Rheumatology Research Group, University of Birmingham, Birmingham, Department of Rheumatology, Russell's Hall Hospital, Dudley and Department of Renal Immunology, University of Birmingham, Birmingham, UK
    • Bayley, Rachel. Rheumatology Research Group, University of Birmingham, Birmingham, Department of Rheumatology, Russell's Hall Hospital, Dudley and Department of Renal Immunology, University of Birmingham, Birmingham, UK
    • Yang, Peiming. Rheumatology Research Group, University of Birmingham, Birmingham, Department of Rheumatology, Russell's Hall Hospital, Dudley and Department of Renal Immunology, University of Birmingham, Birmingham, UK
    • Smith, Jacqueline P.. Rheumatology Research Group, University of Birmingham, Birmingham, Department of Rheumatology, Russell's Hall Hospital, Dudley and Department of Renal Immunology, University of Birmingham, Birmingham, UK
    • Williams, Julie. Rheumatology Research Group, University of Birmingham, Birmingham, Department of Rheumatology, Russell's Hall Hospital, Dudley and Department of Renal Immunology, University of Birmingham, Birmingham, UK
    • Harper, Lorraine. Rheumatology Research Group, University of Birmingham, Birmingham, Department of Rheumatology, Russell's Hall Hospital, Dudley and Department of Renal Immunology, University of Birmingham, Birmingham, UK
    • Kitas, George D.. Rheumatology Research Group, University of Birmingham, Birmingham, Department of Rheumatology, Russell's Hall Hospital, Dudley and Department of Renal Immunology, University of Birmingham, Birmingham, UK
    • Buckley, Christopher. Rheumatology Research Group, University of Birmingham, Birmingham, Department of Rheumatology, Russell's Hall Hospital, Dudley and Department of Renal Immunology, University of Birmingham, Birmingham, UK
    • Young, Stephen P.. Rheumatology Research Group, University of Birmingham, Birmingham, Department of Rheumatology, Russell's Hall Hospital, Dudley and Department of Renal Immunology, University of Birmingham, Birmingham, UK
    • Fitzpatrick, Martin A.. CTIR, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
    • Young, Stephen P.. CTIR, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
    • McGettrick, Helen M.. Rheumatoid Arthritis Centre for Excellence, University of Birmingham, Birmingham, System Sciences for Health, University of Birmingham, Birmingham and Centre for Cardiovascular Sciences, University of Birmingham, Birmingham, UK
    • Filer, Andrew. Rheumatoid Arthritis Centre for Excellence, University of Birmingham, Birmingham, System Sciences for Health, University of Birmingham, Birmingham and Centre for Cardiovascular Sciences, University of Birmingham, Birmingham, UK
    • Raza, Karim. Rheumatoid Arthritis Centre for Excellence, University of Birmingham, Birmingham, System Sciences for Health, University of Birmingham, Birmingham and Centre for Cardiovascular Sciences, University of Birmingham, Birmingham, UK
    • Nash, Gerard. Rheumatoid Arthritis Centre for Excellence, University of Birmingham, Birmingham, System Sciences for Health, University of Birmingham, Birmingham and Centre for Cardiovascular Sciences, University of Birmingham, Birmingham, UK
    • Buckley, Christopher. Rheumatoid Arthritis Centre for Excellence, University of Birmingham, Birmingham, System Sciences for Health, University of Birmingham, Birmingham and Centre for Cardiovascular Sciences, University of Birmingham, Birmingham, UK
    • Muthana, Munitta. Infection and Immunity, University of Sheffield, Sheffield, Oncology, University of Sheffield, Sheffield and Chemistry, University of Sheffield, Sheffield, UK
    • Davies, Holly. Infection and Immunity, University of Sheffield, Sheffield, Oncology, University of Sheffield, Sheffield and Chemistry, University of Sheffield, Sheffield, UK
    • Khetan, Sachin. Infection and Immunity, University of Sheffield, Sheffield, Oncology, University of Sheffield, Sheffield and Chemistry, University of Sheffield, Sheffield, UK
    • Adeleke, Gbadebo. Infection and Immunity, University of Sheffield, Sheffield, Oncology, University of Sheffield, Sheffield and Chemistry, University of Sheffield, Sheffield, UK
    • Hawtree, Sarah. Infection and Immunity, University of Sheffield, Sheffield, Oncology, University of Sheffield, Sheffield and Chemistry, University of Sheffield, Sheffield, UK
    • Tazzyman, Simon. Infection and Immunity, University of Sheffield, Sheffield, Oncology, University of Sheffield, Sheffield and Chemistry, University of Sheffield, Sheffield, UK
    • Morrow, Fiona. Infection and Immunity, University of Sheffield, Sheffield, Oncology, University of Sheffield, Sheffield and Chemistry, University of Sheffield, Sheffield, UK
    • Ciani, Barbara. Infection and Immunity, University of Sheffield, Sheffield, Oncology, University of Sheffield, Sheffield and Chemistry, University of Sheffield, Sheffield, UK
    • Wilson, Gerry. Infection and Immunity, University of Sheffield, Sheffield, Oncology, University of Sheffield, Sheffield and Chemistry, University of Sheffield, Sheffield, UK
    • Quirke, Anne-Marie. Kennedy Institute of Rheumatology, University of Oxford, Oxford, Kennedy Institute of Rheumatology, Imperial College London, London, UK, University of Nebraska Medical Centre, University of Nebraska, Omaha, NE, USA, Department of Medicine, Karolinska Institute, Stockholm, Sweden and Department of Microbiology, Jagiellonian University, Krakow, Poland
    • Lugli, Elena. Kennedy Institute of Rheumatology, University of Oxford, Oxford, Kennedy Institute of Rheumatology, Imperial College London, London, UK, University of Nebraska Medical Centre, University of Nebraska, Omaha, NE, USA, Department of Medicine, Karolinska Institute, Stockholm, Sweden and Department of Microbiology, Jagiellonian University, Krakow, Poland
    • Wegner, Natalia. Kennedy Institute of Rheumatology, University of Oxford, Oxford, Kennedy Institute of Rheumatology, Imperial College London, London, UK, University of Nebraska Medical Centre, University of Nebraska, Omaha, NE, USA, Department of Medicine, Karolinska Institute, Stockholm, Sweden and Department of Microbiology, Jagiellonian University, Krakow, Poland
    • Charles, Peter. Kennedy Institute of Rheumatology, University of Oxford, Oxford, Kennedy Institute of Rheumatology, Imperial College London, London, UK, University of Nebraska Medical Centre, University of Nebraska, Omaha, NE, USA, Department of Medicine, Karolinska Institute, Stockholm, Sweden and Department of Microbiology, Jagiellonian University, Krakow, Poland
    • Hamilton, Bart. Kennedy Institute of Rheumatology, University of Oxford, Oxford, Kennedy Institute of Rheumatology, Imperial College London, London, UK, University of Nebraska Medical Centre, University of Nebraska, Omaha, NE, USA, Department of Medicine, Karolinska Institute, Stockholm, Sweden and Department of Microbiology, Jagiellonian University, Krakow, Poland
    • Chowdhury, Muslima. Kennedy Institute of Rheumatology, University of Oxford, Oxford, Kennedy Institute of Rheumatology, Imperial College London, London, UK, University of Nebraska Medical Centre, University of Nebraska, Omaha, NE, USA, Department of Medicine, Karolinska Institute, Stockholm, Sweden and Department of Microbiology, Jagiellonian University, Krakow, Poland
    • Ytterberg, Jimmy. Kennedy Institute of Rheumatology, University of Oxford, Oxford, Kennedy Institute of Rheumatology, Imperial College London, London, UK, University of Nebraska Medical Centre, University of Nebraska, Omaha, NE, USA, Department of Medicine, Karolinska Institute, Stockholm, Sweden and Department of Microbiology, Jagiellonian University, Krakow, Poland
    • Potempa, Jan. Kennedy Institute of Rheumatology, University of Oxford, Oxford, Kennedy Institute of Rheumatology, Imperial College London, London, UK, University of Nebraska Medical Centre, University of Nebraska, Omaha, NE, USA, Department of Medicine, Karolinska Institute, Stockholm, Sweden and Department of Microbiology, Jagiellonian University, Krakow, Poland
    • Fisher, Benjamin. Kennedy Institute of Rheumatology, University of Oxford, Oxford, Kennedy Institute of Rheumatology, Imperial College London, London, UK, University of Nebraska Medical Centre, University of Nebraska, Omaha, NE, USA, Department of Medicine, Karolinska Institute, Stockholm, Sweden and Department of Microbiology, Jagiellonian University, Krakow, Poland
    • Thiele, Geoffrey. Kennedy Institute of Rheumatology, University of Oxford, Oxford, Kennedy Institute of Rheumatology, Imperial College London, London, UK, University of Nebraska Medical Centre, University of Nebraska, Omaha, NE, USA, Department of Medicine, Karolinska Institute, Stockholm, Sweden and Department of Microbiology, Jagiellonian University, Krakow, Poland
    • Mikuls, Ted. Kennedy Institute of Rheumatology, University of Oxford, Oxford, Kennedy Institute of Rheumatology, Imperial College London, London, UK, University of Nebraska Medical Centre, University of Nebraska, Omaha, NE, USA, Department of Medicine, Karolinska Institute, Stockholm, Sweden and Department of Microbiology, Jagiellonian University, Krakow, Poland
    • Venables, Patrick. Kennedy Institute of Rheumatology, University of Oxford, Oxford, Kennedy Institute of Rheumatology, Imperial College London, London, UK, University of Nebraska Medical Centre, University of Nebraska, Omaha, NE, USA, Department of Medicine, Karolinska Institute, Stockholm, Sweden and Department of Microbiology, Jagiellonian University, Krakow, Poland
    • Adebajo, Adewale O.. Rheumatology, University of Sheffield, Sheffield, UK, Rheumatology, University of California San Diego, San Diego, CA, Rheumatology, Swedish Medical Centre and University of Washington School of Medicine, Seattle, WA, USA, Rheumatology, Hospital Clinico Universitario, Santiago, Spain, Rheumatology, Schön Klinik Hamburg Eilbek, Hamburg, Germany and Research and Development, Celgene Corporation, Warren, NJ, USA
    • Kavanaugh, Arthur. Rheumatology, University of Sheffield, Sheffield, UK, Rheumatology, University of California San Diego, San Diego, CA, Rheumatology, Swedish Medical Centre and University of Washington School of Medicine, Seattle, WA, USA, Rheumatology, Hospital Clinico Universitario, Santiago, Spain, Rheumatology, Schön Klinik Hamburg Eilbek, Hamburg, Germany and Research and Development, Celgene Corporation, Warren, NJ, USA
    • Mease, Philip. Rheumatology, University of Sheffield, Sheffield, UK, Rheumatology, University of California San Diego, San Diego, CA, Rheumatology, Swedish Medical Centre and University of Washington School of Medicine, Seattle, WA, USA, Rheumatology, Hospital Clinico Universitario, Santiago, Spain, Rheumatology, Schön Klinik Hamburg Eilbek, Hamburg, Germany and Research and Development, Celgene Corporation, Warren, NJ, USA
    • Gomez-Reino, Juan J.. Rheumatology, University of Sheffield, Sheffield, UK, Rheumatology, University of California San Diego, San Diego, CA, Rheumatology, Swedish Medical Centre and University of Washington School of Medicine, Seattle, WA, USA, Rheumatology, Hospital Clinico Universitario, Santiago, Spain, Rheumatology, Schön Klinik Hamburg Eilbek, Hamburg, Germany and Research and Development, Celgene Corporation, Warren, NJ, USA
    • Wollenhaupt, Jurgen. Rheumatology, University of Sheffield, Sheffield, UK, Rheumatology, University of California San Diego, San Diego, CA, Rheumatology, Swedish Medical Centre and University of Washington School of Medicine, Seattle, WA, USA, Rheumatology, Hospital Clinico Universitario, Santiago, Spain, Rheumatology, Schön Klinik Hamburg Eilbek, Hamburg, Germany and Research and Development, Celgene Corporation, Warren, NJ, USA
    • Hu, ChiaChi. Rheumatology, University of Sheffield, Sheffield, UK, Rheumatology, University of California San Diego, San Diego, CA, Rheumatology, Swedish Medical Centre and University of Washington School of Medicine, Seattle, WA, USA, Rheumatology, Hospital Clinico Universitario, Santiago, Spain, Rheumatology, Schön Klinik Hamburg Eilbek, Hamburg, Germany and Research and Development, Celgene Corporation, Warren, NJ, USA
    • Stevens, Randall. Rheumatology, University of Sheffield, Sheffield, UK, Rheumatology, University of California San Diego, San Diego, CA, Rheumatology, Swedish Medical Centre and University of Washington School of Medicine, Seattle, WA, USA, Rheumatology, Hospital Clinico Universitario, Santiago, Spain, Rheumatology, Schön Klinik Hamburg Eilbek, Hamburg, Germany and Research and Development, Celgene Corporation, Warren, NJ, USA
    • Sieper, Joachim. Department of Medicine/Rheumatology, Charité Universitätesmedizin Berlin, Berlin, Germany, Department of Rheumatology, Leiden University Medical Centre, Leiden, Netherlands, Department of Rheumatology, Hospital Cochin, Paris, France, Department of Rheumatology, Ghent University Hospital, Ghent, Belgium, Department of Rheumatology, CHRU de Tours, Hôpital Trousseau, Tours, France, Data and Statistical Sciences, AbbVie, North Chicago, IL and Immunology Development, AbbVie, North Chicago, IL, USA
    • van der Heijde, Desiree. Department of Medicine/Rheumatology, Charité Universitätesmedizin Berlin, Berlin, Germany, Department of Rheumatology, Leiden University Medical Centre, Leiden, Netherlands, Department of Rheumatology, Hospital Cochin, Paris, France, Department of Rheumatology, Ghent University Hospital, Ghent, Belgium, Department of Rheumatology, CHRU de Tours, Hôpital Trousseau, Tours, France, Data and Statistical Sciences, AbbVie, North Chicago, IL and Immunology Development, AbbVie, North Chicago, IL, USA
    • Dougados, Maxime. Department of Medicine/Rheumatology, Charité Universitätesmedizin Berlin, Berlin, Germany, Department of Rheumatology, Leiden University Medical Centre, Leiden, Netherlands, Department of Rheumatology, Hospital Cochin, Paris, France, Department of Rheumatology, Ghent University Hospital, Ghent, Belgium, Department of Rheumatology, CHRU de Tours, Hôpital Trousseau, Tours, France, Data and Statistical Sciences, AbbVie, North Chicago, IL and Immunology Development, AbbVie, North Chicago, IL, USA
    • Van den Bosch, Filip. Department of Medicine/Rheumatology, Charité Universitätesmedizin Berlin, Berlin, Germany, Department of Rheumatology, Leiden University Medical Centre, Leiden, Netherlands, Department of Rheumatology, Hospital Cochin, Paris, France, Department of Rheumatology, Ghent University Hospital, Ghent, Belgium, Department of Rheumatology, CHRU de Tours, Hôpital Trousseau, Tours, France, Data and Statistical Sciences, AbbVie, North Chicago, IL and Immunology Development, AbbVie, North Chicago, IL, USA
    • Goupille, Philippe. Department of Medicine/Rheumatology, Charité Universitätesmedizin Berlin, Berlin, Germany, Department of Rheumatology, Leiden University Medical Centre, Leiden, Netherlands, Department of Rheumatology, Hospital Cochin, Paris, France, Department of Rheumatology, Ghent University Hospital, Ghent, Belgium, Department of Rheumatology, CHRU de Tours, Hôpital Trousseau, Tours, France, Data and Statistical Sciences, AbbVie, North Chicago, IL and Immunology Development, AbbVie, North Chicago, IL, USA
    • Rathmann, Suchitrita S.. Department of Medicine/Rheumatology, Charité Universitätesmedizin Berlin, Berlin, Germany, Department of Rheumatology, Leiden University Medical Centre, Leiden, Netherlands, Department of Rheumatology, Hospital Cochin, Paris, France, Department of Rheumatology, Ghent University Hospital, Ghent, Belgium, Department of Rheumatology, CHRU de Tours, Hôpital Trousseau, Tours, France, Data and Statistical Sciences, AbbVie, North Chicago, IL and Immunology Development, AbbVie, North Chicago, IL, USA
    • Pangan, Aileen L.. Department of Medicine/Rheumatology, Charité Universitätesmedizin Berlin, Berlin, Germany, Department of Rheumatology, Leiden University Medical Centre, Leiden, Netherlands, Department of Rheumatology, Hospital Cochin, Paris, France, Department of Rheumatology, Ghent University Hospital, Ghent, Belgium, Department of Rheumatology, CHRU de Tours, Hôpital Trousseau, Tours, France, Data and Statistical Sciences, AbbVie, North Chicago, IL and Immunology Development, AbbVie, North Chicago, IL, USA
    • van der Heijde, Desiree. Rheumatology, Leiden University Medical Centre, Leiden, Netherlands, Gastroenterology and Rheumatology, Charité Universitätsmedizin, Berlin, Germany, Medicine, University of Alberta, Edmonton, AB, Canada, Autoimmunity Program, University of Queensland Diamantina Institute, Brisbane, QLD, Australia, Data and Statistical Sciences, AbbVie, North Chicago and Immunology Development, AbbVie, North Chicago, IL, USA
    • Sieper, Joachim. Rheumatology, Leiden University Medical Centre, Leiden, Netherlands, Gastroenterology and Rheumatology, Charité Universitätsmedizin, Berlin, Germany, Medicine, University of Alberta, Edmonton, AB, Canada, Autoimmunity Program, University of Queensland Diamantina Institute, Brisbane, QLD, Australia, Data and Statistical Sciences, AbbVie, North Chicago and Immunology Development, AbbVie, North Chicago, IL, USA
    • Maksymowych, Walter P.. Rheumatology, Leiden University Medical Centre, Leiden, Netherlands, Gastroenterology and Rheumatology, Charité Universitätsmedizin, Berlin, Germany, Medicine, University of Alberta, Edmonton, AB, Canada, Autoimmunity Program, University of Queensland Diamantina Institute, Brisbane, QLD, Australia, Data and Statistical Sciences, AbbVie, North Chicago and Immunology Development, AbbVie, North Chicago, IL, USA
    • Brown, Matthew A.. Rheumatology, Leiden University Medical Centre, Leiden, Netherlands, Gastroenterology and Rheumatology, Charité Universitätsmedizin, Berlin, Germany, Medicine, University of Alberta, Edmonton, AB, Canada, Autoimmunity Program, University of Queensland Diamantina Institute, Brisbane, QLD, Australia, Data and Statistical Sciences, AbbVie, North Chicago and Immunology Development, AbbVie, North Chicago, IL, USA
    • Rathmann, Suchitrita. Rheumatology, Leiden University Medical Centre, Leiden, Netherlands, Gastroenterology and Rheumatology, Charité Universitätsmedizin, Berlin, Germany, Medicine, University of Alberta, Edmonton, AB, Canada, Autoimmunity Program, University of Queensland Diamantina Institute, Brisbane, QLD, Australia, Data and Statistical Sciences, AbbVie, North Chicago and Immunology Development, AbbVie, North Chicago, IL, USA
    • Pangan, Aileen L.. Rheumatology, Leiden University Medical Centre, Leiden, Netherlands, Gastroenterology and Rheumatology, Charité Universitätsmedizin, Berlin, Germany, Medicine, University of Alberta, Edmonton, AB, Canada, Autoimmunity Program, University of Queensland Diamantina Institute, Brisbane, QLD, Australia, Data and Statistical Sciences, AbbVie, North Chicago and Immunology Development, AbbVie, North Chicago, IL, USA
    • Sieper, Joachim. Department of Medicine/Rheumatology, Charité Universitätesmedizin Berlin, Berlin, Germany, Department of Rheumatology, Leiden University Medical Centre, Leiden, Netherlands, Department of Rheumatology, Ghent University Hospital, Ghent, Belgium and Immunology Development, AbbVie, North Chicago, IL, USA
    • van der Heijde, Desiree. Department of Medicine/Rheumatology, Charité Universitätesmedizin Berlin, Berlin, Germany, Department of Rheumatology, Leiden University Medical Centre, Leiden, Netherlands, Department of Rheumatology, Ghent University Hospital, Ghent, Belgium and Immunology Development, AbbVie, North Chicago, IL, USA
    • Elewaut, Dirk. Department of Medicine/Rheumatology, Charité Universitätesmedizin Berlin, Berlin, Germany, Department of Rheumatology, Leiden University Medical Centre, Leiden, Netherlands, Department of Rheumatology, Ghent University Hospital, Ghent, Belgium and Immunology Development, AbbVie, North Chicago, IL, USA
    • Pangan, Aileen L.. Department of Medicine/Rheumatology, Charité Universitätesmedizin Berlin, Berlin, Germany, Department of Rheumatology, Leiden University Medical Centre, Leiden, Netherlands, Department of Rheumatology, Ghent University Hospital, Ghent, Belgium and Immunology Development, AbbVie, North Chicago, IL, USA
    • Anderson, Jaclyn. Department of Medicine/Rheumatology, Charité Universitätesmedizin Berlin, Berlin, Germany, Department of Rheumatology, Leiden University Medical Centre, Leiden, Netherlands, Department of Rheumatology, Ghent University Hospital, Ghent, Belgium and Immunology Development, AbbVie, North Chicago, IL, USA
    • Haroon, Muhammad. Department of Rheumatology, St Vincent's University Hospital, Dublin and Department of Ophthalmology, Royal Victoria Eye and Ear Hospital, Dublin, Ireland
    • Ramasamy, Pathma. Department of Rheumatology, St Vincent's University Hospital, Dublin and Department of Ophthalmology, Royal Victoria Eye and Ear Hospital, Dublin, Ireland
    • O'Rourke, Michael. Department of Rheumatology, St Vincent's University Hospital, Dublin and Department of Ophthalmology, Royal Victoria Eye and Ear Hospital, Dublin, Ireland
    • Murphy, Conor. Department of Rheumatology, St Vincent's University Hospital, Dublin and Department of Ophthalmology, Royal Victoria Eye and Ear Hospital, Dublin, Ireland
    • Fitzgerald, Oliver. Department of Rheumatology, St Vincent's University Hospital, Dublin and Department of Ophthalmology, Royal Victoria Eye and Ear Hospital, Dublin, Ireland
    • Jani, Meghna. Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, Department of Rheumatology, Salford Royal NHS Foundation Trust, Salford, Department of Rheumatology, Trafford General Hospital, Manchester, Department of Rheumatology, University Hospital of South Manchester, Manchester, Department of Rheumatology, Lancashire Teaching Hospitals, Preston and Department of Rheumatology, Blackpool Teaching Hospitals, Blackpool, UK
    • Moore, Sarah. Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, Department of Rheumatology, Salford Royal NHS Foundation Trust, Salford, Department of Rheumatology, Trafford General Hospital, Manchester, Department of Rheumatology, University Hospital of South Manchester, Manchester, Department of Rheumatology, Lancashire Teaching Hospitals, Preston and Department of Rheumatology, Blackpool Teaching Hospitals, Blackpool, UK
    • Mirjafari, Hoda. Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, Department of Rheumatology, Salford Royal NHS Foundation Trust, Salford, Department of Rheumatology, Trafford General Hospital, Manchester, Department of Rheumatology, University Hospital of South Manchester, Manchester, Department of Rheumatology, Lancashire Teaching Hospitals, Preston and Department of Rheumatology, Blackpool Teaching Hospitals, Blackpool, UK
    • Macphie, Elizabeth. Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, Department of Rheumatology, Salford Royal NHS Foundation Trust, Salford, Department of Rheumatology, Trafford General Hospital, Manchester, Department of Rheumatology, University Hospital of South Manchester, Manchester, Department of Rheumatology, Lancashire Teaching Hospitals, Preston and Department of Rheumatology, Blackpool Teaching Hospitals, Blackpool, UK
    • Chinoy, Hector. Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, Department of Rheumatology, Salford Royal NHS Foundation Trust, Salford, Department of Rheumatology, Trafford General Hospital, Manchester, Department of Rheumatology, University Hospital of South Manchester, Manchester, Department of Rheumatology, Lancashire Teaching Hospitals, Preston and Department of Rheumatology, Blackpool Teaching Hospitals, Blackpool, UK
    • Rao, Chan. Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, Department of Rheumatology, Salford Royal NHS Foundation Trust, Salford, Department of Rheumatology, Trafford General Hospital, Manchester, Department of Rheumatology, University Hospital of South Manchester, Manchester, Department of Rheumatology, Lancashire Teaching Hospitals, Preston and Department of Rheumatology, Blackpool Teaching Hospitals, Blackpool, UK
    • McLoughlin, Yokemei. Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, Department of Rheumatology, Salford Royal NHS Foundation Trust, Salford, Department of Rheumatology, Trafford General Hospital, Manchester, Department of Rheumatology, University Hospital of South Manchester, Manchester, Department of Rheumatology, Lancashire Teaching Hospitals, Preston and Department of Rheumatology, Blackpool Teaching Hospitals, Blackpool, UK
    • Preeti, Shah. Rheumatology, University of Texas Southwestern, Dallas, TX, USA, 2Rheumatology, Karolinska Institute, Stockholm, Sweden, 3Institute of Rheumatology, Medical University of Vienna and Hietzing Hospital, Vienna, Austria, 4Musculoskeletal Disease, Leeds Teaching Hospital, Leeds, UK, 5Rheumatology Medical Affairs, AbbVie, Rungis, France, 6Data and Statistical Sciences, AbbVie, North Chicago, IL, USA, 7Immunology Development, AbbVie GmbH and Co. KG, Ludwigshafen, Germany and 8Rheumatology, Allergy and Immunology, University of California San Diego, La Jolla, CA, USA
    Dokumententyp
    • Postprint
    OAI-PMH-ID
    • oai:doc.rero.ch:301969
    Summary
    Background: This analysis assessed, on a group level, whether there is a long-term advantage for early RA patients treated with adalimumab (ADA) + MTX vs those initially treated with placebo (PBO) + MTX who either responded to therapy or added ADA following inadequate response (IR). Methods: OPTIMA was a 78- week, randomized, controlled trial of ADA + MTX vs PBO + MTX in MTX-naïve early (<1 year) RA patients. Therapy was adjusted at week 26: ADA + MTX-responders (R) who achieved DAS28 (CRP) <3.2 at weeks 22 and 26 (Period 1, P1) were re-randomized to withdraw or continue ADA and PBO + MTX-R continued randomized therapy for 52 weeks (P2); IR-patients received open-label (OL) ADA + MTX during P2. This post hoc analysis evaluated the proportion of patients at week 78 with DAS28 (CRP) <3.2, HAQ-DI <0.5, and/or ΔmTSS ≤0.5 by initial treatment. To account for patients who withdrew ADA during P2, an equivalent proportion of R was imputed from ADA + MTX-R patients. Results: At week 26, significantly more patients had low disease activity, normal function, and/or no radiographic progression with ADA + MTX vs PBO + MTX (Table 1). Differences in clinical and functional outcomes disappeared following additional treatment, when PBO + MTX-IR (n = 348/460) switched to OL ADA + MTX. Addition of OL ADA slowed radiographic progression, but more patients who received ADA + MTX from baseline had no radiographic progression at week 78 than patients who received initial PBO + MTX. Conclusions: Early RA patients treated with PBO + MTX achieved comparable long-term clinical and functional outcomes on a group level as those who began ADA + MTX, but only when therapy was optimized by the addition of ADA in PBO + MTX-IR. Still, ADA + MTX therapy conferred a radiographic benefit although the difference did not appear to translate to an additional functional benefit. Disclosures: P.E., AbbVie, Merck, Pfizer, UCB, Roche, BMS—Provided Expert Advice, Undertaken Trials, AbbVie—AbbVie sponsored the study, contributed to its design, and participated in the collection, analysis, and interpretation of the data, and in the writing, reviewing, and approval of the final version. R.F., AbbVie, Pfizer, Merck, Roche, UCB, Celgene, Amgen, AstraZeneca, BMS, Janssen, Lilly, Novartis—Research Grants, Consultation Fees. S.F., AbbVie—Employee, Stocks. A.K., AbbVie, Amgen, AstraZeneca, BMS, Celgene, Centocor-Janssen, Pfizer, Roche, UCB—Research Grants, Consultation Fees. H.K., AbbVie—Employee, Stocks. S.R., AbbVie—Employee, Stocks. J.S., AbbVie, Amgen, AstraZeneca, BMS, Celgene, Centocor-Janssen, GlaxoSmithKline, Lilly, Pfizer (Wyeth), MSD (Schering-Plough), Novo-Nordisk, Roche, Sandoz, UCB—Research Grants, Consultation Fees. R.V., AbbVie, BMS, GlaxoSmithKline, Human Genome Sciences, Merck, Pfizer, Roche, UCB Pharma—Consultation Fees, Research Support. Table 1.Week 78 clinical, functional, and radiographic outcomes in patients who received continued ADA + MTX vs those who continued PBO + MTX or added open-label ADA following an inadequate response ADA + MTX, n/N (%)a PBO + MTX, n/N (%)b Outcome Week 26 Week 52 Week 78 Week 26 Week 52 Week 78 DAS28 (CRP) <3.2 246/466 (53) 304/465 (65) 303/465 (65) 139/460 (30)*** 284/460 (62) 300/460 (65) HAQ-DI <0.5 211/466 (45) 220/466 (47) 224/466 (48) 150/460 (33)*** 203/460 (44) 208/460 (45) ΔmTSS ≤0.5 402/462 (87) 379/445 (86) 382/443 (86) 330/459 (72)*** 318/440 (72)*** 318/440 (72)*** DAS28 (CRP) <3.2 + ΔmTSS ≤0.5 216/462 (47) 260/443 (59) 266/443 (60) 112/459 (24)*** 196/440 (45) 211/440 (48)*** DAS28 (CRP) <3.2 + HAQ-DI <0.5 + ΔmTSS ≤0.5 146/462 (32) 168/443 (38) 174/443 (39) 82/459 (18)*** 120/440 (27)*** 135/440 (31)** aIncludes patients from the ADA Continuation (n = 105) and OL ADA Carry On (n = 259) arms, as well as the proportional equivalent number of responders from the ADA Withdrawal arm (n = 102). bIncludes patients from the MTX Continuation (n = 112) and Rescue ADA (n = 348) arms. Last observation carried forward: DAS28 (CRP) and HAQ-DI; Multiple imputations: ΔmTSS. ***P < 0.001 and **iP < 0.01, respectively, for differences between initial treatments from chi-square