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Efficacy and side effects of praziquantel against Schistosoma mansoni in a community of western Côte d'Ivoire

Raso, Giovanna ; N'Goran, Eliézer K. ; Toty, Abale ; Luginbühl, Anne ; Adjoua, Cynthia A. ; Tian-Bi, Norbert T. ; Bogoch, Isaac I. ; Vounatsou, Penelope ; Tanner, Marcel ; Utzinger, Jürg

In: Transactions of The Royal Society of Tropical Medicine and Hygiene, 2004, vol. 98, no. 1, p. 18-27

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    Titre
    • Efficacy and side effects of praziquantel against Schistosoma mansoni in a community of western Côte d'Ivoire
    Auteur
    • Raso, Giovanna. Swiss Tropical Institute, P.O. Box, CH-4002 Basel, Switzerland
    • N'Goran, Eliézer K.. Centre Suisse de Recherches Scientifiques, 01 BP 1303, Abidjan 01, Côte d'Ivoire
    • Toty, Abale. Direction Départementale de la Santé de Man, Man, Côte d'Ivoire
    • Luginbühl, Anne. Centre Suisse de Recherches Scientifiques, 01 BP 1303, Abidjan 01, Côte d'Ivoire
    • Adjoua, Cynthia A.. Centre Suisse de Recherches Scientifiques, 01 BP 1303, Abidjan 01, Côte d'Ivoire
    • Tian-Bi, Norbert T.. UFR Biosciences, Université de Cocody, 22 PB 770, Abidjan 22, Côte d'Ivoire
    • Bogoch, Isaac I.. Centre Suisse de Recherches Scientifiques, 01 BP 1303, Abidjan 01, Côte d'Ivoire
    • Vounatsou, Penelope. Swiss Tropical Institute, P.O. Box, CH-4002 Basel, Switzerland
    • Tanner, Marcel. Swiss Tropical Institute, P.O. Box, CH-4002 Basel, Switzerland
    • Utzinger, Jürg. Office of Population Research, Princeton University, Princeton, NJ 08544, USA
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Transactions of The Royal Society of Tropical Medicine and Hygiene, 2004, vol. 98, no. 1, p. 18-27. Royal Society of Tropical Medicine and Hygiene
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:301791
    Summary
    Praziquantel is efficacious against the adult stages of all human schistosome parasites, and has become the drug of choice for morbidity control of schistosomiasis. There is concern that resistance to praziquantel might develop or already exists, and could be further facilitated through new control initiatives relying on large-scale administration of praziquantel. Therefore, monitoring praziquantel efficacy in different epidemiological settings is required. We assessed the efficacy and side effects of praziquantel against Schistosoma mansoni in a rural community of western Côte d'Ivoire. Three consecutive stool specimens from 545 children and adults were examined by the Kato-Katz technique, revealing an overall prevalence of 40.9%. S. mansoni-infected individuals were treated with a single oral dose of praziquantel at 40 mg/kg. The most frequent side effects were abdominal pain, dizziness and diarrhoea. The overall cure rate, assessed 6 weeks post-treatment, was 60.9%. Moderate or heavy infections were only cleared in half or one-third of the individuals, respectively. The total egg count reduction was 61.4%. Infection intensity pre-treatment was significantly associated with age, cure rate, reported diarrhoea and dizziness. Our findings call for additional studies that rigorously evaluate the efficacy of praziquantel against different schistosome species in entire communities, using similarly sensitive diagnostic approaches as employed here