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Virus Burden in Lymph Nodes and Blood of Subjects with Primary Human Immunodeficiency Virus Type 1 Infection on Bitherapy

Perrin, Luc ; Yerly, Sabine ; Marchal, Francis ; Schockmel, Gérard A. ; Hirschel, Bernard ; Fox, Cecil H. ; Pantaleo, Giuseppe

In: Journal of Infectious Diseases, 1998, vol. 177, no. 6, p. 1497-1501

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    Titre
    • Virus Burden in Lymph Nodes and Blood of Subjects with Primary Human Immunodeficiency Virus Type 1 Infection on Bitherapy
    Auteur
    • Perrin, Luc. Laboratory of Virology, AIDS Centre, Division of Infectious Diseases, Department of Otho-Rhino-Laryngology, Geneva University Hospital, Geneva, Lausanne, Switzerland, Gaithersburg, Maryland
    • Yerly, Sabine. Laboratory of Virology, AIDS Centre, Division of Infectious Diseases, Department of Otho-Rhino-Laryngology, Geneva University Hospital, Geneva, Lausanne, Switzerland, Gaithersburg, Maryland
    • Marchal, Francis. Laboratory of Virology, AIDS Centre, Division of Infectious Diseases, Department of Otho-Rhino-Laryngology, Geneva University Hospital, Geneva, Lausanne, Switzerland, Gaithersburg, Maryland
    • Schockmel, Gérard A.. Laboratory of Virology, AIDS Centre, Division of Infectious Diseases, Department of Otho-Rhino-Laryngology, Geneva University Hospital, Geneva, Lausanne, Switzerland, Gaithersburg, Maryland
    • Hirschel, Bernard. Laboratory of Virology, AIDS Centre, Division of Infectious Diseases, Department of Otho-Rhino-Laryngology, Geneva University Hospital, Geneva, Lausanne, Switzerland, Gaithersburg, Maryland
    • Fox, Cecil H.. Laboratory of Virology, AIDS Centre, Division of Infectious Diseases, Department of Otho-Rhino-Laryngology, Geneva University Hospital, Geneva, Lausanne, Switzerland, Gaithersburg, Maryland
    • Pantaleo, Giuseppe. Laboratory of Virology, AIDS Centre, Division of Infectious Diseases, Department of Otho-Rhino-Laryngology, Geneva University Hospital, Geneva, Lausanne, Switzerland, Gaithersburg, Maryland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Journal of Infectious Diseases, 1998, vol. 177, no. 6, p. 1497-1501. The University of Chicago Press
    Autre version électronique
    Classification
    • Santé
    Identifiant OAI-PMH
    • oai:doc.rero.ch:301695
    Summary
    At present, it is not known whether undetectable plasma viremia corresponds to an absence of human immunodeficiency virus type 1 (HIV-1) replication in lymphoid tissues. This issue has been explored in 11 subjects with primary HIV-1 infection treated with zidovudine plus didanosine by evaluating virologic markers in blood and lymphoid tissues 9-18 months after initiation of treatment. These markers include plasma viremia, measured with a sensitive assay with a detection limit of 20 HIV-1 RNA copies/mL, infectious virus titers and proviral DNA in lymph node mononuclear cells, and HIV-1 RNA in lymphoid tissue. Five subjects had plasma viremia < 20 copies/mL and showed no evidence of viral replication in lymphoid tissue. Six subjects had both detectable plasma viremia and evidence of HIV-1 RNA in lymphoid tissue. The results indicate that absence of detectable HIV RNA in lymphoid tissue is associated with viremia levels of HIV-1 RNA < 20 copies/mL