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Fibronectin Is More Active than Fibrin or Fibrinogen in Promoting Staphylococcus aureus Adherence to Inserted Intravascular Catheters

Vaudaux, Pierre ; Pittet, Didier ; Haeberli, André ; Lerch, Peter G. ; Morgenthaler, Jean-Jacques ; Proctor, Richard A. ; Waldvogel, Francis A. ; Lew, Daniel P.

In: Journal of Infectious Diseases, 1993, vol. 167, no. 3, p. 633-641

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    Titre
    • Fibronectin Is More Active than Fibrin or Fibrinogen in Promoting Staphylococcus aureus Adherence to Inserted Intravascular Catheters
    Auteur
    • Vaudaux, Pierre. Division of Infectious Diseases, University Hospital, Geneva, and Thrombosis Research Laboratory, University Hospital and Central Laboratory, Blood Transfusion Service Swiss Red Cros, Bern, Switzerland, Madison
    • Pittet, Didier. Division of Infectious Diseases, University Hospital, Geneva, and Thrombosis Research Laboratory, University Hospital and Central Laboratory, Blood Transfusion Service Swiss Red Cros, Bern, Switzerland, Madison
    • Haeberli, André. Division of Infectious Diseases, University Hospital, Geneva, and Thrombosis Research Laboratory, University Hospital and Central Laboratory, Blood Transfusion Service Swiss Red Cros, Bern, Switzerland, Madison
    • Lerch, Peter G.. Division of Infectious Diseases, University Hospital, Geneva, and Thrombosis Research Laboratory, University Hospital and Central Laboratory, Blood Transfusion Service Swiss Red Cros, Bern, Switzerland, Madison
    • Morgenthaler, Jean-Jacques. Division of Infectious Diseases, University Hospital, Geneva, and Thrombosis Research Laboratory, University Hospital and Central Laboratory, Blood Transfusion Service Swiss Red Cros, Bern, Switzerland, Madison
    • Proctor, Richard A.. Division of Infectious Diseases, University Hospital, Geneva, and Thrombosis Research Laboratory, University Hospital and Central Laboratory, Blood Transfusion Service Swiss Red Cros, Bern, Switzerland, Madison
    • Waldvogel, Francis A.. Division of Infectious Diseases, University Hospital, Geneva, and Thrombosis Research Laboratory, University Hospital and Central Laboratory, Blood Transfusion Service Swiss Red Cros, Bern, Switzerland, Madison
    • Lew, Daniel P.. Division of Infectious Diseases, University Hospital, Geneva, and Thrombosis Research Laboratory, University Hospital and Central Laboratory, Blood Transfusion Service Swiss Red Cros, Bern, Switzerland, Madison
    Type de document
    • Postprint
    Langue
    • Inglese
    Publié dans
    • Journal of Infectious Diseases, 1993, vol. 167, no. 3, p. 633-641. The University of Chicago Press
    Autre version électronique
    Classification
    • Santé
    Identifiant OAI-PMH
    • oai:doc.rero.ch:301277
    Summary
    To further define the role of fibrin(ogen) and fibronectin in Staphylococcus aureus adherence to central venous catheters, the amount, chemical integrity, and biologic activity of these proteins adsorbed on lines inserted in hospitalized patients were prospectively studied. Polyurethane cannulas promoted a significantly lower adherence of S. aureus than polyvinyl chloride (P < .01) or Hickman (P < .001) cannulas and contained the lowest amount of immunologically assayed fibronectin but not of fibrin(ogen). Fibrinogen showed an extensive loss of adherence-promoting activity on inserted cannulas, which was related to its proteolytic breakdown, as detected by SDS-PAGE and immunoblots with antifibrinogen antibodies and confirmed by in vitro studies with purified protein fragments. In contrast, either intact or fragmented fibronectin, although present in much lower amounts than fibrin(ogen), could actively promote S. aureus adherence onto intravenous catheters