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IN VITRO EFFECT OF EPHEDRINE, ADRENALINE, NORADRENALINE AND ISOPRENALINE ON HALOTHANE-INDUCED CONTRACTURES IN SKELETAL MUSCLE FROM PATIENTS POTENTIALLY SUSCEPTIBLE TO MALIGNANT HYPERTHERMIA

URWYLER, A. ; CENSIER, K. ; SEEBERGER, M. D. ; ROTHENBUHLER, J. M. ; KAUFMANN, M. A. ; DREWE, J.

In: BJA: British Journal of Anaesthesia, 1993, vol. 70, no. 1, p. 76-79

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    Titel
    • IN VITRO EFFECT OF EPHEDRINE, ADRENALINE, NORADRENALINE AND ISOPRENALINE ON HALOTHANE-INDUCED CONTRACTURES IN SKELETAL MUSCLE FROM PATIENTS POTENTIALLY SUSCEPTIBLE TO MALIGNANT HYPERTHERMIA
    Autor
    • URWYLER, A.. Department of Anaesthesia and Research, University of Basel Kantonsspital, CH-4031 Basel, Switzerland.
    • CENSIER, K.. Department of Anaesthesia and Research, University of Basel Kantonsspital, CH-4031 Basel, Switzerland.
    • SEEBERGER, M. D.. Department of Anaesthesia and Research, University of Basel Kantonsspital, CH-4031 Basel, Switzerland.
    • ROTHENBUHLER, J. M.. Department of Surgery, University of Basel Kantonsspital, CH-4031 Basel, Switzerland.
    • KAUFMANN, M. A.. Department of Anaesthesia and Research, University of Basel Kantonsspital, CH-4031 Basel, Switzerland.
    • DREWE, J.. Department of Anaesthesia and Research, University of Basel Kantonsspital, CH-4031 Basel, Switzerland.
    Dokumententyp
    • Postprint
    Sprache
    • Englisch
    Veröffentlicht in
    • BJA: British Journal of Anaesthesia, 1993, vol. 70, no. 1, p. 76-79. Oxford University Press
    Andere elektronische Ausgabe
    OAI-PMH-ID
    • oai:doc.rero.ch:301104
    Summary
    SUMMARY We have measured the effects of ephedrine, adrenaline, noradrenaline and isoprenaline on halothaneinduced contractures in muscle biopsies from patients potentially susceptible to malignant hyperthermia (MH). At concentrations of 4-24 mmol litre−1, ephedrine induced in vitro contractures in halothane 0.44 mmol litre−1-prechallenged muscle, whilst adrenaline, noradrenaline and isoprenaline had no effect. There was a shift of the ephedrine concentration-response curve to theleft and an increased maximum muscle contracturein the MH susceptible group compared with the MH negative group (P < 0.001). We conclude that ephedrine increased halothane-induced muscle contractures in vitro either by an unknown pharmacological mechanism or by an adrenergic stimulation which was different from those of the other investigatedadrenoceptoragonists. (Br. J. Anaesth. 1993; 70:76-79)