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DOSE REQUIREMENTS AND PLASMA CONCENTRATIONS OF PIPECURONIUM DURING BILATERAL RENAL EXCLUSION AND ORTHOTOPIC LIVER TRANSPLANTATION IN PIGS

PITTET, J. F. ; TASSONYI, E. ; SCHOPFER, C. ; MOREL, D. R. ; LEEMANN, P. ; MENTHA, G. ; COULTRE, C. LE ; STEINIG, D. A. ; BENAKIS, A.

In: BJA: British Journal of Anaesthesia, 1990, vol. 65, no. 6, p. 779-785

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    Titre
    • DOSE REQUIREMENTS AND PLASMA CONCENTRATIONS OF PIPECURONIUM DURING BILATERAL RENAL EXCLUSION AND ORTHOTOPIC LIVER TRANSPLANTATION IN PIGS
    Auteur
    • PITTET, J. F.. Department of Anaesthesiology, University Medical Center CH-1211 Geneva, Switzerland
    • TASSONYI, E.. Department of Anaesthesiology, University Medical Center CH-1211 Geneva, Switzerland
    • SCHOPFER, C.. Department of Pharmacology, University Medical Center CH-1211 Geneva, Switzerland
    • MOREL, D. R.. Department of Anaesthesiology, University Medical Center CH-1211 Geneva, Switzerland
    • LEEMANN, P.. Department of Anaesthesiology, University Medical Center CH-1211 Geneva, Switzerland
    • MENTHA, G.. Department of Surgery, University Medical Center CH-1211 Geneva, Switzerland
    • COULTRE, C. LE. Department of Surgery, University Medical Center CH-1211 Geneva, Switzerland
    • STEINIG, D. A.. Department of Surgery, University Medical Center CH-1211 Geneva, Switzerland
    • BENAKIS, A.. Department of Pharmacology, University Medical Center CH-1211 Geneva, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • BJA: British Journal of Anaesthesia, 1990, vol. 65, no. 6, p. 779-785. Oxford University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:300989
    Summary
    We have studied five pigs undergoing bilateral clamping of the renal pedicles, seven pigs undergoing orthotopic liver transplantation and three control animals without surgery in order to examine the roles of the kidney and liver in the plasma clearance of pipecuronium. An i.v. infusion of pipecuronium was controlled to maintain a constant 90-95 % twitch depression throughout the investigation. The right sciatic nerve was stimulated continuously with supra-maximal stimuli at 0.1 Hz and the force of the corresponding evoked isometric muscle contraction was recorded continuously. Control pigs needed an infusion rate of pipecuronium 8-10.7 μg kg−1 min−1. In the renal group, it was necessary to reduce the infusion rate of pipecuronium by about 25% after clamping both renal vascular pedicles (P < 0.05 compared with controls); in pigs undergoing liver transplantation, it was necessary to reduce the rate by approximately 80% after clamping hepatic vessels (P < 0.05 compared with controls and from the period after clamping of renal vessels). After hepatic recirculation, the infusion rate of pipecuronium was increased progressively to a rate which corresponded to 50% of baseline values (P < 0.05 compared with the anhepatic phase and from controls). Plasma concentrations of pipecuronium were comparable in the three animal groups and did not change significantly during the study. These data suggest that the liver plays a more important role than the kidney in the plasma clearance of pipecuronium in pigs