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Dissemination of carbapenemase-producing Enterobacteriaceae in France, 2012

Dortet, Laurent ; Cuzon, Gaelle ; Nordmann, Patrice

In: Journal of Antimicrobial Chemotherapy, 2014, vol. 69, no. 3, p. 623-627

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    Titre
    • Dissemination of carbapenemase-producing Enterobacteriaceae in France, 2012
    Auteur
    • Dortet, Laurent. INSERM U914 ‘Emerging Resistance to Antibiotics', Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris Sud, K.-Bicêtre, France
    • Cuzon, Gaelle. INSERM U914 ‘Emerging Resistance to Antibiotics', Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris Sud, K.-Bicêtre, France
    • Nordmann, Patrice. INSERM U914 ‘Emerging Resistance to Antibiotics', Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris Sud, K.-Bicêtre, France
    Type de document
    • Postprint
    Langue
    • Inglese
    Publié dans
    • Journal of Antimicrobial Chemotherapy, 2014, vol. 69, no. 3, p. 623-627. Oxford University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:300862
    Summary
    Objectives Carbapenem-resistant Enterobacteriaceae isolates (n = 1485) were received at the French Associated National Reference Center for Antibiotic Resistance in 2012 and were characterized for their mechanism of resistance to carbapenems. Methods Carbapenemase production was detected using the biochemical-based Carba NP test, based on the detection of in vitro hydrolysis of imipenem. All isolates with a positive Carba NP test result were characterized by PCR and sequencing. Results Carbapenemase production was identified in 23.1% of the isolates. The main carbapenemase type identified was OXA-48 and derivatives (75.5%). An overseas source was clearly demonstrated for only 27.6% of the isolates. Conclusions OXA-48 and derivatives are now the most prevalent carbapenemases in France, with a possible spread of these producers in the community