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Retinoic acid inhibits the fixation of initial transformational damage in X-irradiated Balb/3T3 mouse fibroblasts in vitro

Rutz, Hans Peter ; Little, John B.

In: Carcinogenesis, 1989, vol. 10, no. 12, p. 2183-2186

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    Title
    • Retinoic acid inhibits the fixation of initial transformational damage in X-irradiated Balb/3T3 mouse fibroblasts in vitro
    Author
    • Rutz, Hans Peter. Present address: Laboratoire de Radiobiologie, Service de Radiothérapie, Centre Hospitalier Universitaire Vaudois CH-1011 Lausanne, Switzerland
    • Little, John B.. Harvard School of Public Health, Department of Cancer Biology, 665 Huntington Avenue, Boston, MA 02115, USA, CH-1011 Lausanne, Switzerland
    Document Type
    • Postprint
    OAI-PMH Identifier
    • oai:doc.rero.ch:300738
    Summary
    We have examined the effects of all-trans retinoic acid (RA) on confluent holding recovery (cell survival) and on the fixation of initial transformational damage expressed as the ultimate yield of transformed foci following X-irradiation of density-inhibited cultures of Balb/3T3 cells. Non-cytotoxic concentrations of RA suppressed both recovery of potentially lethal damage and neoplastic transformation in a dosedependent manner when added for 24 h during postirradiation confluent holding after a dose of 5 Gy. At 100 μM, RA inhibited the fixation of initial transformational damage by 80%. These findings are discussed in terms of the hypothesis that retinoids may allow a selective enhancement of the inactivation of certain irradiated tumor cells in vivo while reducing the risk of secondary malignancies in successfully treated patients