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Influence of Granulocytes on Brain Edema, Intracranial Pressure, and Cerebrospinal Fluid Concentrations of Lactate and Protein in Experimental Meningitis

Täuber, Martin G. ; Borschberg, Urs ; Sande, Merle A.

In: Journal of Infectious Diseases, 1988, vol. 157, no. 3, p. 456-464

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    Titre
    • Influence of Granulocytes on Brain Edema, Intracranial Pressure, and Cerebrospinal Fluid Concentrations of Lactate and Protein in Experimental Meningitis
    Auteur
    • Täuber, Martin G.. From the Division of Infectious Diseases, Department of Medicine, University Hospital, Zurich, Switzerland, San Francisco, California
    • Borschberg, Urs. From the Division of Infectious Diseases, Department of Medicine, University Hospital, Zurich, Switzerland, San Francisco, California
    • Sande, Merle A.. From the Division of Infectious Diseases, Department of Medicine, University Hospital, Zurich, Switzerland, San Francisco, California
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Journal of Infectious Diseases, 1988, vol. 157, no. 3, p. 456-464. The University of Chicago Press
    Autre version électronique
    Classification
    • Santé
    Identifiant OAI-PMH
    • oai:doc.rero.ch:300091
    Summary
    Brain water content (brain edema), intracranial pressure, and cerebrospinal fluid (CSF) concentrations of lactate and protein increased significantly during 24 h of experimental meningitis due to Streptococcus pneumoniae, but changes were similar in normal and neutropenic rabbits. In sterile meningitis induced by N-formyl-methionyl-leucyl-phenyl-alanine (fMLP), low and high doses of fMLP were equally effective in inducing CSF pleocytosis, whereas only high doses of fMLP caused brain edema. High doses of fMLP injected intracisternally during pneumococcal meningitis also increased brain water content. The fMLP did not significantly increase intracranial pressure or CSF concentrations of lactate or protein in sterile or pneumococcal meningitis, nor did it cause brain edema in neutropenic animals. Thus, granulocytes may contribute to brain edema during meningitis if adequately stimulated, but intracranial pressure and CSF protein and lactate concentrations appear independent of granulocytes. Stimulation does not appear to occur early in meningitis, when granulocytes were without effect on brain edema