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Guidelines for molecular genetic detection of susceptibility to malignant hyperthermia†

Urwyler, A. ; Deufel, T. ; McCarthy, T. ; West, S.

In: British Journal of Anaesthesia, 2001, vol. 86, no. 2, p. 283-287

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    Title
    • Guidelines for molecular genetic detection of susceptibility to malignant hyperthermia†
    Author
    • Urwyler, A.. Departments of Anaesthesia and Research, Kantonsspital, University of Basel, CH‐4031 Basel, Switzerland. Institute for Clinical Chemistry and Laboratory Diagnosis, University of Jena, D‐07743 Jena, Germany. Department of Biochemistry, University College Cork, Cork, Republic of Ireland. Northern Genetics Service, Molecular Genetics Unit, Newcastle upon Tyne NE2 4AA, UK*Corresponding author
    • Deufel, T.. Departments of Anaesthesia and Research, Kantonsspital, University of Basel, CH‐4031 Basel, Switzerland. Institute for Clinical Chemistry and Laboratory Diagnosis, University of Jena, D‐07743 Jena, Germany. Department of Biochemistry, University College Cork, Cork, Republic of Ireland. Northern Genetics Service, Molecular Genetics Unit, Newcastle upon Tyne NE2 4AA, UK*Corresponding author
    • McCarthy, T.. Departments of Anaesthesia and Research, Kantonsspital, University of Basel, CH‐4031 Basel, Switzerland. Institute for Clinical Chemistry and Laboratory Diagnosis, University of Jena, D‐07743 Jena, Germany. Department of Biochemistry, University College Cork, Cork, Republic of Ireland. Northern Genetics Service, Molecular Genetics Unit, Newcastle upon Tyne NE2 4AA, UK*Corresponding author
    • West, S.. Departments of Anaesthesia and Research, Kantonsspital, University of Basel, CH‐4031 Basel, Switzerland. Institute for Clinical Chemistry and Laboratory Diagnosis, University of Jena, D‐07743 Jena, Germany. Department of Biochemistry, University College Cork, Cork, Republic of Ireland. Northern Genetics Service, Molecular Genetics Unit, Newcastle upon Tyne NE2 4AA, UK*Corresponding author
    Document Type
    • Postprint
    Language
    • English
    Published in
    • British Journal of Anaesthesia, 2001, vol. 86, no. 2, p. 283-287. Oxford University Press
    Other Version
    OAI-PMH Identifier
    • oai:doc.rero.ch:299167
    Summary
    Malignant hyperthermia (MH) is a potentially fatal pharmacogenetic disease triggered by several anaesthetic agents. The in vitro muscle contracture test (IVCT) is the standard test to establish an individual's risk of susceptibility to MH. Clinical practitioners and geneticists of the European MH Group have agreed on the present guidelines for the detection of MH susceptibility using molecular genetic techniques and/or IVCT to predict the risk of MH. Br J Anaesth 2001; 86: 283-7