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A Case Series of Acquired Drug Resistance-Associated Mutations in Human Immunodeficiency Virus-Infected Children: An Emerging Public Health Concern in Rural Africa

Gamell, Anna ; Muri, Lukas ; Ntamatungiro, Alex ; Nyogea, Daniel ; Luwanda, Lameck B. ; Hatz, Christoph ; Battegay, Manuel ; Felger, Ingrid ; Tanner, Marcel ; Klimkait, Thomas ; Letang, Emilio

In: Open Forum Infectious Diseases, 2015, vol. 3, no. 1, p. -

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    Title
    • A Case Series of Acquired Drug Resistance-Associated Mutations in Human Immunodeficiency Virus-Infected Children: An Emerging Public Health Concern in Rural Africa
    Author
    • Gamell, Anna. Swiss Tropical and Public Health Institute, Basel
    • Muri, Lukas. Swiss Tropical and Public Health Institute, Basel
    • Ntamatungiro, Alex. Ifakara Health Institute, United Republic of Tanzania
    • Nyogea, Daniel. Ifakara Health Institute, United Republic of Tanzania
    • Luwanda, Lameck B.. Ifakara Health Institute, United Republic of Tanzania
    • Hatz, Christoph. Swiss Tropical and Public Health Institute, Basel
    • Battegay, Manuel. University of Basel
    • Felger, Ingrid. Swiss Tropical and Public Health Institute, Basel
    • Tanner, Marcel. Swiss Tropical and Public Health Institute, Basel
    • Klimkait, Thomas. Molecular Virology, Department Biomedicine-Petersplatz, University of Basel, Switzerland
    • Letang, Emilio. Swiss Tropical and Public Health Institute, Basel
    Document Type
    • Postprint
    Language
    • English
    Published in
    • Open Forum Infectious Diseases, 2015, vol. 3, p. 1. Oxford University Press
    Other Version
    OAI-PMH Identifier
    • oai:doc.rero.ch:299087
    Summary
    The acquisition of drug-resistance mutations among African children living with in human immunodeficiency virus on antiretroviral treatment has been scarcely reported. This threatens the overall success of antiretroviral programs and the clinical outcomes of children in care. We present a well characterized series of children from rural Tanzania with acquired drug-resistance mutations to contribute to the better understanding of this emerging public health concern