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Nosocomial Outbreak of Multiple Bloodborne Viral Infections

Yerly, Sabine ; Quadri, Rafael ; Negro, Francesco ; Barbe, KlaraPosfay ; Cheseaux, Jean‐Jacques ; Burgisser, Philippe ; Siegrist, Claire‐Anne ; Perrin, Luc

In: The Journal of Infectious Diseases, 2001, vol. 184, no. 3, p. 369-372

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    Titel
    • Nosocomial Outbreak of Multiple Bloodborne Viral Infections
    Autor
    • Yerly, Sabine. Laboratory of Virology, Division of Infectious Diseases, Divisions of
    • Quadri, Rafael. Gastroenterology and Hepatology and of
    • Negro, Francesco. Gastroenterology and Hepatology and of
    • Barbe, KlaraPosfay. Pediatric Department, Geneva University Hospital, Geneva, and
    • Cheseaux, Jean‐Jacques. Pediatric Department and
    • Burgisser, Philippe. Division of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    • Siegrist, Claire‐Anne. Pediatric Department, Geneva University Hospital, Geneva, and
    • Perrin, Luc. Laboratory of Virology, Division of Infectious Diseases, Divisions of
    Dokumententyp
    • Postprint
    Sprache
    • Englisch
    Veröffentlicht in
    • The Journal of Infectious Diseases, 2001, vol. 184, no. 3, p. 369-372. University of Chicago Press
    Andere elektronische Ausgabe
    Klassifikation
    • Gesundheit
    OAI-PMH-ID
    • oai:doc.rero.ch:299034
    Summary
    In resource‐limited countries, nosocomial transmission of bloodborne pathogens is a major public health concern. After a major outbreak of human immunodeficiency virus (HIV) infection in ∼400 children in 1998 in Libya, we tested HIV, hepatitis C virus (HCV), and hepatitis B virus (HBV) markers in 148 children and collected epidemiological data in a subgroup of 37 children and 46 parents. HIV infection was detected in all children but one, with HCV or HBV coinfection in 47% and 33%, respectively. Vertical transmission was ruled out by analysis of parents' serology. The children visited the same hospital 1-6 times; at each visit, invasive procedures with potential blood transmission of virus were performed. HIV and HCV genotypic analyses identified a HIV monophyletic group, whereas 4 clusters of HCV sequences were identified. To our knowledge, this is the largest documented outbreak of nosocomial HIV transmission