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The Role of Reinfection and Partner Notification in the Efficacy of Chlamydia Screening Programs

Heijne, Janneke C.M. ; Althaus, Christian L. ; Herzog, Sereina A. ; Kretzschmar, Mirjam ; Low, Nicola

In: Journal of Infectious Diseases, 2011, vol. 203, no. 3, p. 372-377

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    Title
    • The Role of Reinfection and Partner Notification in the Efficacy of Chlamydia Screening Programs
    Author
    • Heijne, Janneke C.M.. Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
    • Althaus, Christian L.. Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
    • Herzog, Sereina A.. Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
    • Kretzschmar, Mirjam. Centre for Infectious Disease Control, RIVM, Bilthoven
    • Low, Nicola. Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
    Document Type
    • Postprint
    Language
    • English
    Published in
    • Journal of Infectious Diseases, 2011, vol. 203, no. 3, p. 372-377. Oxford University Press
    Other Version
    OAI-PMH Identifier
    • oai:doc.rero.ch:298879
    Summary
    Repeated Chlamydia trachomatis infections after treatment are common. One reason is reinfection from untreated partners in ongoing sexual partnerships. Mathematical models that are used to predict the impact of screening on reducing chlamydia prevalence often do not incorporate reinfection and might overestimate the expected impact. We describe a pair compartmental model that explicitly incorporates sexual partnership duration and reinfection. The pair model predicts a weaker impact of screening when compared directly with a model that does not accommodate partnerships. Effective management of sex partners to prevent reinfection might need to be strengthened in chlamydia control programs