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The 30-bp Deletion Variant of Epstein-Barr Virus-Encoded Latent Membrane Protein-1 Prevails in Acute Infectious Mononucleosis

Berger, Christoph ; McQuain, Cathy ; Sullivan, John L. ; Nadal, David ; Quesenberry, Peter J. ; Knecht, Hans

In: Journal of Infectious Diseases, 1997, vol. 176, no. 5, p. 1370-1373

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    Titre
    • The 30-bp Deletion Variant of Epstein-Barr Virus-Encoded Latent Membrane Protein-1 Prevails in Acute Infectious Mononucleosis
    Auteur
    • Berger, Christoph. LINK Laboratories (Cancer Center) and Department of Pediatrics, University of Massachusetts Medical Center, Worcester, Massachusetts, Zurich, Switzerland
    • McQuain, Cathy. LINK Laboratories (Cancer Center) and Department of Pediatrics, University of Massachusetts Medical Center, Worcester, Massachusetts, Zurich, Switzerland
    • Sullivan, John L.. LINK Laboratories (Cancer Center) and Department of Pediatrics, University of Massachusetts Medical Center, Worcester, Massachusetts, Zurich, Switzerland
    • Nadal, David. LINK Laboratories (Cancer Center) and Department of Pediatrics, University of Massachusetts Medical Center, Worcester, Massachusetts, Zurich, Switzerland
    • Quesenberry, Peter J.. LINK Laboratories (Cancer Center) and Department of Pediatrics, University of Massachusetts Medical Center, Worcester, Massachusetts, Zurich, Switzerland
    • Knecht, Hans. LINK Laboratories (Cancer Center) and Department of Pediatrics, University of Massachusetts Medical Center, Worcester, Massachusetts, Zurich, Switzerland
    Type de document
    • Postprint
    Langue
    • Inglese
    Publié dans
    • Journal of Infectious Diseases, 1997, vol. 176, no. 5, p. 1370-1373. The University of Chicago Press
    Autre version électronique
    Classification
    • Santé
    Identifiant OAI-PMH
    • oai:doc.rero.ch:298464
    Summary
    To assess the frequency of malignancy-associated 30-bp deletion variants of the latent membrane protein 1 (LMP-1) in benign conditions, a comparative sequence analysis was done using samples from 20 American children with acute infectious mononucleosis and 16 Swiss children with chronic tonsillar hyperplasia. The 30-bp deletion variant (LMP-1-del) was present in 66% of patients (12/20 with infectious mononucleosis and 12/16 with tonsillar hyperplasia). Two additional patients had a 3-bp deletion and an inframe insertion of 18 nucleotides, respectively. All but 1 isolate had numerous nonsilent point mutations. These data identify a hypervariable region within the Cterminus of LMP-1, in a domain required for maximal stimulation of NF-κB activity. These data demonstrate that LMP-1-del variants are frequent in acute infectious mononucleosis and tonsillar hyperplasia and identical to those observed in Epstein-Barr virus-associated AIDS-related lymphoma