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Reduced risk of clinical malaria in children infected with multiple clones of Plasmodium falciparum in a highly endemic area: a prospective community study

Al-Yaman, F. ; Genton, B. ; Reeder, J.C. ; Anders, R.F. ; Smith, T. ; Alpers, M.P.

In: Transactions of The Royal Society of Tropical Medicine and Hygiene, 1997, vol. 91, no. 5, p. 602-605

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    Titre
    • Reduced risk of clinical malaria in children infected with multiple clones of Plasmodium falciparum in a highly endemic area: a prospective community study
    Auteur
    • Al-Yaman, F.. Papua New Guinea Institute of Medical Research, P.O. Box 378, Madang, Papua New Guinea
    • Genton, B.. Papua New Guinea Institute of Medical Research, P.O. Box 378, Madang, Papua New Guinea
    • Reeder, J.C.. Walter and Eliza Hall Institute of Medical Research, P.O. Royal Melbourne Hospital, Victoria 3050, Australia
    • Anders, R.F.. Walter and Eliza Hall Institute of Medical Research, P.O. Royal Melbourne Hospital, Victoria 3050, Australia
    • Smith, T.. Swiss Tropical Institute, Socinstrasse 57, CH-4002, Basel, Switzerland
    • Alpers, M.P.. Papua New Guinea Institute of Medical Research, P.O. Box 378, Madang, Papua New Guinea
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Transactions of The Royal Society of Tropical Medicine and Hygiene, 1997, vol. 91, no. 5, p. 602-605. Royal Society of Tropical Medicine and Hygiene
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:298039
    Summary
    A prospective community study in a highly malaria endemic area of Papua New Guinea found that infection with multiple Plasmodium falciparum genotypes was an indicator of lowered risk of subsequent clinical attack. The results suggest that concurrent or very recent infections provide protection from superinfecting parasites. The finding of an association between reduced risk of clinical malaria and infection with parasites of merozoite surface protein 1 (MSP-1) type RO33 or MSP-2 type 3D7 further suggests that the concomitant immunity is, at least in part, a consequence of a response to these major merozoite surface proteins