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Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls

Timofeeva, Maria N. ; Hung, Rayjean J. ; Rafnar, Thorunn ; Christiani, David C. ; Field, John K. ; Bickeböller, Heike ; Risch, Angela ; McKay, James D. ; Wang, Yufei ; Dai, Juncheng ; Gaborieau, Valerie ; McLaughlin, John ; Brenner, Darren ; Narod, Steven A. ; Caporaso, Neil E. ; Albanes, Demetrius ; Thun, Michael ; Eisen, Timothy ; Wichmann, H.-Erich ; Rosenberger, Albert ; Han, Younghun ; Chen, Wei ; Zhu, Dakai ; Spitz, Margaret ; Wu, Xifeng ; Pande, Mala ; Zhao, Yang ; Zaridze, David ; Szeszenia-Dabrowska, Neonilia ; Lissowska, Jolanta ; Rudnai, Peter ; Fabianova, Eleonora ; Mates, Dana ; Bencko, Vladimir ; Foretova, Lenka ; Janout, Vladimir ; Krokan, Hans E. ; Gabrielsen, Maiken Elvestad ; Skorpen, Frank ; Vatten, Lars ; Njølstad, Inger ; Chen, Chu ; Goodman, Gary ; Lathrop, Mark ; Benhamou, Simone ; Vooder, Tõnu ; Välk, Kristjan ; Nelis, Mari ; Metspalu, Andres ; Raji, Olaide ; Chen, Ying ; Gosney, John ; Liloglou, Triantafillos ; Muley, Thomas ; Dienemann, Hendrik ; Thorleifsson, Gudmar ; Shen, Hongbing ; Stefansson, Kari ; Brennan, Paul ; Amos, Christopher I. ; Houlston, Richard ; Landi, Maria Teresa

In: Human Molecular Genetics, 2012, vol. 21, no. 22, p. 4980-4995

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    Titre
    • Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls
    Auteur
    • Timofeeva, Maria N.. International Agency for Research on Cancer, Lyon 69008, France
    • Hung, Rayjean J.. Samuel Lunenfeld Research Institute of Mount Sinai Hospital, Toronto, ON, Canada M5G 1X5
    • Rafnar, Thorunn. DeCODE Genetics, Reykjavik, Iceland
    • Christiani, David C.. Harvard University School of Public Health, Boston, MA 02115, USA
    • Field, John K.. Roy Castle Lung Cancer Research Programme, Department of Molecular and Clinical Cancer Medicine, The University of Liverpool Cancer Research Centre, Institute of Translational Medicine, The University of Liverpool, Liverpool, UK
    • Bickeböller, Heike. Department of Genetic Epidemiology, University Medical Center, Georg-August-University Göttingen, 37073 Göttingen, Germany
    • Risch, Angela. DKFZ - German Cancer Research Center, Translational Lung Research Centre Heidelberg (TLRC-H), Member of the German Center for Lung Research, 69120 Heidelberg, Germany
    • McKay, James D.. International Agency for Research on Cancer, Lyon 69008, France
    • Wang, Yufei. Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK
    • Dai, Juncheng. Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China
    • Gaborieau, Valerie. International Agency for Research on Cancer, Lyon 69008, France
    • McLaughlin, John. Samuel Lunenfeld Research Institute of Mount Sinai Hospital, Toronto, ON, Canada M5G 1X5
    • Brenner, Darren. Samuel Lunenfeld Research Institute of Mount Sinai Hospital, Toronto, ON, Canada M5G 1X5
    • Narod, Steven A.. Women's College Research Institute, Toronto, Ontario, Canada
    • Caporaso, Neil E.. Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, U.S. Public Health Service, Bethesda, MD 20892, USA
    • Albanes, Demetrius. Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, U.S. Public Health Service, Bethesda, MD 20892, USA
    • Thun, Michael. American Cancer Society, Epidemiology and Surveillance Research, Atlanta, GA 30301, USA
    • Eisen, Timothy. Department of Oncology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
    • Wichmann, H.-Erich. Helmholtz Center Munich, Institute of Epidemiology I, 85764 Neuherberg, Germany
    • Rosenberger, Albert. Department of Genetic Epidemiology, University Medical Center, Georg-August-University Göttingen, 37073 Göttingen, Germany
    • Han, Younghun. Department of Geneticsand
    • Chen, Wei. Department of Geneticsand
    • Zhu, Dakai. Department of Geneticsand
    • Spitz, Margaret. Baylor College of Medicine, Houston, TX 77030, USA
    • Wu, Xifeng. Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    • Pande, Mala. Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    • Zhao, Yang. Harvard University School of Public Health, Boston, MA 02115, USA
    • Zaridze, David. Institute of Carcinogenesis, Russian N.N. Blokhin Cancer Research Centre, 115478 Moscow, Russia
    • Szeszenia-Dabrowska, Neonilia. Department of Epidemiology, Institute of Occupational Medicine, 91348 Lodz, Poland
    • Lissowska, Jolanta. The M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw 02781, Poland
    • Rudnai, Peter. National Institute of Environmental Health, Budapest 1097, Hungary
    • Fabianova, Eleonora. Regional Authority of Public Health, Banská Bystrica 97556, Slovak Republic
    • Mates, Dana. National Institute of Public Health, Bucharest 050463, Romania
    • Bencko, Vladimir. 1st Faculty of Medicine, Institute of Hygiene and Epidemiology, Charles University in Prague, 128 00 Prague 2, Czech Republic
    • Foretova, Lenka. Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno 65653, Czech Republic
    • Janout, Vladimir. Palacky University, Olomouc 77515, Czech Republic
    • Krokan, Hans E.. Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim 7489, Norway
    • Gabrielsen, Maiken Elvestad. Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim 7489, Norway
    • Skorpen, Frank. Department of Laboratory Medicine, Children's and Women's Health, Faculty of Medicine and
    • Vatten, Lars. Department of Public Health and General Practice, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim 7489, Norway
    • Njølstad, Inger. Department of Community Medicine, University of Tromso, Tromso 9037, Norway
    • Chen, Chu. Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    • Goodman, Gary. Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    • Lathrop, Mark. Centre d'Etude du Polymorphisme Humain (CEPH), Paris 75010, France
    • Benhamou, Simone. INSERM U946, Paris 75010, France
    • Vooder, Tõnu. Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia
    • Välk, Kristjan. Competence Centre on Reproductive Medicine and Biology, 50410 Tartu, Estonia
    • Nelis, Mari. Estonian Genome Center, Institute of Molecular and Cell Biology, Tartu 51010, Estonia
    • Metspalu, Andres. Estonian Genome Center, Institute of Molecular and Cell Biology, Tartu 51010, Estonia
    • Raji, Olaide. Roy Castle Lung Cancer Research Programme, Department of Molecular and Clinical Cancer Medicine, The University of Liverpool Cancer Research Centre, Institute of Translational Medicine, The University of Liverpool, Liverpool, UK
    • Chen, Ying. Roy Castle Lung Cancer Research Programme, Department of Molecular and Clinical Cancer Medicine, The University of Liverpool Cancer Research Centre, Institute of Translational Medicine, The University of Liverpool, Liverpool, UK
    • Gosney, John. Roy Castle Lung Cancer Research Programme, Department of Molecular and Clinical Cancer Medicine, The University of Liverpool Cancer Research Centre, Institute of Translational Medicine, The University of Liverpool, Liverpool, UK
    • Liloglou, Triantafillos. Roy Castle Lung Cancer Research Programme, Department of Molecular and Clinical Cancer Medicine, The University of Liverpool Cancer Research Centre, Institute of Translational Medicine, The University of Liverpool, Liverpool, UK
    • Muley, Thomas. Translational Research Unit and
    • Dienemann, Hendrik. Department of Thoracic Surgery, Thoraxklinik am Universitätsklinikum Heidelberg, Germany
    • Thorleifsson, Gudmar. DeCODE Genetics, Reykjavik, Iceland
    • Shen, Hongbing. Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China
    • Stefansson, Kari. DeCODE Genetics, Reykjavik, Iceland
    • Brennan, Paul. International Agency for Research on Cancer, Lyon 69008, France
    • Amos, Christopher I.. Department of Geneticsand
    • Houlston, Richard. Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK
    • Landi, Maria Teresa. Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, U.S. Public Health Service, Bethesda, MD 20892, USA
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Human Molecular Genetics, 2012, vol. 21, no. 22, p. 4980-4995. Oxford University Press
    Autre version électronique
    Classification
    • Santé
    Identifiant OAI-PMH
    • oai:doc.rero.ch:297971
    Summary
    Recent genome-wide association studies (GWASs) have identified common genetic variants at 5p15.33, 6p21-6p22 and 15q25.1 associated with lung cancer risk. Several other genetic regions including variants of CHEK2 (22q12), TP53BP1 (15q15) and RAD52 (12p13) have been demonstrated to influence lung cancer risk in candidate- or pathway-based analyses. To identify novel risk variants for lung cancer, we performed a meta-analysis of 16 GWASs, totaling 14 900 cases and 29 485 controls of European descent. Our data provided increased support for previously identified risk loci at 5p15 (P = 7.2 × 10−16), 6p21 (P = 2.3 × 10−14) and 15q25 (P = 2.2 × 10−63). Furthermore, we demonstrated histology-specific effects for 5p15, 6p21 and 12p13 loci but not for the 15q25 region. Subgroup analysis also identified a novel disease locus for squamous cell carcinoma at 9p21 (CDKN2A/p16INK4A/p14ARF/CDKN2B/p15INK4B/ANRIL; rs1333040, P = 3.0 × 10−7) which was replicated in a series of 5415 Han Chinese (P = 0.03; combined analysis, P = 2.3 × 10−8). This large analysis provides additional evidence for the role of inherited genetic susceptibility to lung cancer and insight into biological differences in the development of the different histological types of lung cancer