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A Recombinant Blood-Stage Malaria Vaccine Reduces Plasmodium falciparum Density and Exerts Selective Pressure on Parasite Populations in a Phase 1-2b Trial in Papua New Guinea

Genton, Blaise ; Betuela, Inoni ; Felger, Ingrid ; Al-Yaman, Fadwa ; Anders, Robin F. ; Saul, Allan ; Rare, Lawrence ; Baisor, Moses ; Lorry, Kerry ; Brown, Graham V. ; Pye, David ; Irving, David O. ; Smith, Thomas A. ; Beck, Hans-Peter ; Alpers, Michael P.

In: The Journal of Infectious Diseases, 2002, vol. 185, no. 6, p. 820-827

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    Titre
    • A Recombinant Blood-Stage Malaria Vaccine Reduces Plasmodium falciparum Density and Exerts Selective Pressure on Parasite Populations in a Phase 1-2b Trial in Papua New Guinea
    Auteur
    • Genton, Blaise. Papua New Guinea Institute of Medical Research, Maprik, Papua New Guinea
    • Betuela, Inoni. Papua New Guinea Institute of Medical Research, Maprik, Papua New Guinea
    • Felger, Ingrid. Papua New Guinea Institute of Medical Research, Maprik, Papua New Guinea
    • Al-Yaman, Fadwa. Papua New Guinea Institute of Medical Research, Maprik, Papua New Guinea
    • Anders, Robin F.. Walter and Eliza Hall Institute of Medical Research, Melbourne
    • Saul, Allan. Queensland Institute of Medical Research, Brisbane
    • Rare, Lawrence. Papua New Guinea Institute of Medical Research, Maprik, Papua New Guinea
    • Baisor, Moses. Papua New Guinea Institute of Medical Research, Maprik, Papua New Guinea
    • Lorry, Kerry. Papua New Guinea Institute of Medical Research, Maprik, Papua New Guinea
    • Brown, Graham V.. Walter and Eliza Hall Institute of Medical Research, Melbourne
    • Pye, David. CSL, Melbourne
    • Irving, David O.. Biotech Australia, Sydney, Australia
    • Smith, Thomas A.. Swiss Tropical Institute, Basel, Switzerland
    • Beck, Hans-Peter. Swiss Tropical Institute, Basel, Switzerland
    • Alpers, Michael P.. Papua New Guinea Institute of Medical Research, Maprik, Papua New Guinea
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • The Journal of Infectious Diseases, 2002, vol. 185, no. 6, p. 820-827. The University of Chicago Press
    Autre version électronique
    Classification
    • Santé
    Identifiant OAI-PMH
    • oai:doc.rero.ch:297945
    Summary
    The malaria vaccine Combination B comprises recombinant Plasmodium falciparum ring-infected erythrocyte surface antigen and 2 merozoite surface proteins (MSP1 and MSP2) formulated in oil-based adjuvant. A phase 1-2b double-blind, randomized, placebo-controlled trial in 120 children (5-9 years old) in Papua New Guinea demonstrated a 62% (95% confidence limits: 13%, 84%) reduction in parasite density in children not pretreated with sulfadoxine-pyrimethamine. Vaccinees had a lower prevalence of parasites carrying the MSP2-3D7 allelic form (corresponding to that in the vaccine) and a higher incidence of morbid episodes associated with FC27-type parasites. These results demonstrate functional activity of Combination B against P. falciparum in individuals with previous malaria exposure. The specific effects on parasites with particular msp2 genotypes suggest that the MSP2 component, at least in part, accounted for the activity. The vaccine-induced selection pressure exerted on the parasites and its consequences for morbidity strongly argue for developing vaccines comprising conserved antigens and/or multiple components covering all important allelic types