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Efavirenz Intoxication Due to Slow Hepatic Metabolism

Hasse, B. ; Günthard, H. F. ; Bleiber, G. ; Krause, M.

In: Clinical Infectious Diseases, 2005, vol. 40, no. 3, p. e22-e23

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    Title
    • Efavirenz Intoxication Due to Slow Hepatic Metabolism
    Author
    • Hasse, B.. Department of Internal Medicine, Cantonal Hospital of Muensterlingen, Muensterlingen, Zurich
    • Günthard, H. F.. Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Zurich, Zurich
    • Bleiber, G.. Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Lausanne, Lausanne, Switzerland
    • Krause, M.. Department of Internal Medicine, Cantonal Hospital of Muensterlingen, Muensterlingen, Zurich
    Document Type
    • Postprint
    Language
    • English
    Published in
    • Clinical Infectious Diseases, 2005, vol. 40, no. 3, p. e22-e23. The University of Chicago Press
    Other Version
    Classification
    • Health
    OAI-PMH Identifier
    • oai:doc.rero.ch:297937
    Summary
    We describe a human immunodeficiency virus-positive woman who presented with severe psychosis while she was receiving therapy with efavirenz. Her plasma efavirenz level was excessively high. Genetic investigation showed that she was homozygous for the CYP2B6 G516T allele, resulting in slow hepatic metabolism. After the dosage of efavirenz was lowered, all neuropsychiatric symptoms subsided