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P-621: Metabolic determinants of proximal sodium reabsorption in healthy women

Zanchi, Anne ; Bochud, Murielle ; Decosterd, Dumeng ; Maillard, Marc ; Burnier, Michel

In: American Journal of Hypertension, 2003, vol. 16, no. S1, p. 263A-263A

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    Titre
    • P-621: Metabolic determinants of proximal sodium reabsorption in healthy women
    Auteur
    • Zanchi, Anne. Division of Hypertension and Vascular Medicine, CHUV, Lausanne, Switzerland
    • Bochud, Murielle. Division of Hypertension and Vascular Medicine, CHUV, Lausanne, Switzerland
    • Decosterd, Dumeng. Division of Hypertension and Vascular Medicine, CHUV, Lausanne, Switzerland
    • Maillard, Marc. Division of Hypertension and Vascular Medicine, CHUV, Lausanne, Switzerland
    • Burnier, Michel. Division of Hypertension and Vascular Medicine, CHUV, Lausanne, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • American Journal of Hypertension, 2003, vol. 16, no. S1, p. 263A-263A. Oxford University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:297688
    Summary
    Increased reabsorption of sodium (Na) in the proximal segments of the nephron is present in hypertensive patients. Studies performed in men reported an association between proximal Na reabsorption and features of the metabolic syndrome. This study explores the relationship between metabolic variables and proximal Na reabsorption in healthy women. This study is population-based and cross-sectional examining 661 healthy women aged 40-75y. After 15 minutes rest, blood pressure was measured 3 times, blood was drawn and urine was collected. Fractional excretion of endogenous lithium (FELi) was used as an indirect marker of proximal sodium reabsorption, lithium being only reabsorbed in the proximal tubule. All women receiving blood pressure, blood glucose or lipid lowering therapy were excluded. Correlations: FELi was positively correlated with the fractional excretion of sodium (FENa, r=0.3, p<0.001). FELi was negatively associated with total cholesterol (r=-0.14, P<0.0001), LDL-cholesterol (r=-0.16, P<0.0001), BMI (r=-0.08, P<0.05) and weight (r=-0.09, P<0.05). Menopausal status or a family history of hypertension did not affect the associations. Simple linear regression analysis: age, waist circumference, waist/hip ratio, systolic blood pressure, diastolic blood pressure, Hdl cholesterol, triglycerides, serum uric acid or a family history of hypertension were not significant predictors of FELi. BMI was a significant predictor but the strongest relationships were found between FELi and total cholesterol, LDL-cholesterol and FENa. Multivariate linear regression model: When significant predictors of FELi were examined in a multivariate linear regression model also controlling for age, weight, systolic blood pressure and FENa, total cholesterol (p=0.003) or LDL-cholesterol (p=0.001) significantly and independently predicted FELi. In conclusion, these data suggest that metabolic parameters, in particular total cholesterol and LDL-cholesterol and to a lesser extent weight and BMI, are associated with increased proximal Na reabsorption in a healthy untreated women population. Considering the possible link between increased reabsorption of sodium and the development of hypertension, a major cardiovascular risk factor, this association may provide an additional hypothesis for the increased cardiovascular risk of subjects with the metabolic syndrome