Fulltext

Type III secretion: The bacteria-eukaryotic cell express

Mota, Luís Jaime ; Sorg, Isabel ; Cornelis, Guy R.

In: FEMS Microbiology Letters, 2005, vol. 252, no. 1, p. 1-10

Ajouter à la liste personnelle
    Titre
    • Type III secretion: The bacteria-eukaryotic cell express
    Auteur
    • Mota, Luís Jaime. Biozentrum der Universitåt Basel, Biozentrum, Klingelbergstrasse, 50-70 CH4051 Basel, Switzerland
    • Sorg, Isabel. Biozentrum der Universitåt Basel, Biozentrum, Klingelbergstrasse, 50-70 CH4051 Basel, Switzerland
    • Cornelis, Guy R.. Biozentrum der Universitåt Basel, Biozentrum, Klingelbergstrasse, 50-70 CH4051 Basel, Switzerland
    Type de document
    • Postprint
    Identifiant OAI-PMH
    • oai:doc.rero.ch:297625
    Summary
    Type III secretion (T3S) is an export pathway used by Gram-negative pathogenic bacteria to inject bacterial proteins into the cytosol of eukaryotic host cells. This pathway is characterized by (i) a secretion nanomachine related to the bacterial flagellum, but usually topped by a stiff needle-like structure; (ii) the assembly in the eukaryotic cell membrane of a translocation pore formed by T3S substrates; (iii) a non-cleavable N-terminal secretion signal; (iv) T3S chaperones, assisting the secretion of some substrates; (v) a control mechanism ensuring protein delivery at the right place and time. Here, we review these different aspects focusing in open questions that promise exciting findings in the near future