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Patients at Risk of Complications of Staphylococcus aureus Bloodstream Infection

del Rio, Ana ; Cervera, Carlos ; Moreno, Asunción ; Moreillon, Phillipe ; Miró, José M.

In: Clinical Infectious Diseases, 2009, vol. 48, no. Supplement_4, p. S246-S253

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    Title
    • Patients at Risk of Complications of Staphylococcus aureus Bloodstream Infection
    Author
    • del Rio, Ana. Infectious Diseases Service, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi-Sunyer, University of Barcelona, Barcelona, Spain; and Lausanne, Switzerland
    • Cervera, Carlos. Infectious Diseases Service, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi-Sunyer, University of Barcelona, Barcelona, Spain; and Lausanne, Switzerland
    • Moreno, Asunción. Infectious Diseases Service, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi-Sunyer, University of Barcelona, Barcelona, Spain; and Lausanne, Switzerland
    • Moreillon, Phillipe. Department of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland
    • Miró, José M.. Infectious Diseases Service, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi-Sunyer, University of Barcelona, Barcelona, Spain; and Lausanne, Switzerland
    Document Type
    • Postprint
    Language
    • English
    Published in
    • Clinical Infectious Diseases, 2009, vol. 48, no. Supplement_4, p. S246-S253. The University of Chicago Press
    Other Version
    Classification
    • Health
    OAI-PMH Identifier
    • oai:doc.rero.ch:297199
    Summary
    Staphylococcus aureus is one of the most common causative pathogens of bloodstream infections (BSIs). In approximately one-half of patients with S. aureus BSI, no portal of entry can be documented. This group of patients has a high risk of developing septic metastases. Similarly, patient populations at high risk of S. aureus BSI and BSI-associated complications include patients receiving hemodialysis, injection drug users, patients with diabetes, and patients with preexisting cardiac conditions or other comorbidities. One of the most severe complications of S. aureus BSI is infective endocarditis, and S. aureus is now the most common cause of infective endocarditis in the developed world. Patients with methicillin-resistant S. aureus BSI or infective endocarditis have higher rates of mortality, compared with patients with methicillin-susceptible S. aureus infection. Nasal carriage is the most important source of S. aureus BSI. Better eradication and control strategies, including nasal decolonization and more-active antibiotics, are needed to combat S. aureus BSIs