Early Termination of a Prospective, Randomized Trial Comparing Teicoplanin and Flucloxacillin for Treating Severe Staphylococcal Infections
Calain, Philippe ; Krause, Karl-Heinz ; Vaudaux, Pierre ; Auckenthaler, Raymond ; Lew, Daniel ; Waldvogel, Francis ; Hirschel, Bernard
In: Journal of Infectious Diseases, 1987, vol. 155, no. 2, p. 187-191
Aggiungi alla tua lista- Summary
- In a prospective, randomized trial, teicoplanin (at a 400-mg intravenous loading dose followed by 200 mg/day intravenously or intramuscularly) was compared with flucloxacillin (8 g/day) in patients with severe staphylococcal infections. Teicoplanin proved unsatisfactory for the following reasons: (1) failures or relapses were more frequent in the teicoplanin group, and (2) blood levels were difficult to predict and tended to be low 24 hr after the loading dose. Future trials with this agent should use much-higher doses