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Isolated reduction of haematocrit does not compromise in vitro blood coagulation

Iselin, B. M. ; Willimann, P. F. X. ; Seifert, B. ; Casutt, M. ; Bombeli, T. ; Zalunardo, M. P. ; Pasch, T. ; Spahn, D. R.

In: British Journal of Anaesthesia, 2001, vol. 87, no. 2, p. 246-249

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    Titre
    • Isolated reduction of haematocrit does not compromise in vitro blood coagulation
    Auteur
    • Iselin, B. M.. Institute of Anaesthesiology, University Hospital Zurich, Switzerland. Department of Biostatistics, University of Zurich, Switzerland. Division of Haematology, Department of Internal Medicine, University Hospital Zurich, Switzerland.*Corresponding author: Institute of Anaesthesiology, University Hospital, Raemistrasse 100, CH‐8091 Zürich, Switzerland
    • Willimann, P. F. X.. Institute of Anaesthesiology, University Hospital Zurich, Switzerland. Department of Biostatistics, University of Zurich, Switzerland. Division of Haematology, Department of Internal Medicine, University Hospital Zurich, Switzerland.*Corresponding author: Institute of Anaesthesiology, University Hospital, Raemistrasse 100, CH‐8091 Zürich, Switzerland
    • Seifert, B.. Institute of Anaesthesiology, University Hospital Zurich, Switzerland. Department of Biostatistics, University of Zurich, Switzerland. Division of Haematology, Department of Internal Medicine, University Hospital Zurich, Switzerland.*Corresponding author: Institute of Anaesthesiology, University Hospital, Raemistrasse 100, CH‐8091 Zürich, Switzerland
    • Casutt, M.. Institute of Anaesthesiology, University Hospital Zurich, Switzerland. Department of Biostatistics, University of Zurich, Switzerland. Division of Haematology, Department of Internal Medicine, University Hospital Zurich, Switzerland.*Corresponding author: Institute of Anaesthesiology, University Hospital, Raemistrasse 100, CH‐8091 Zürich, Switzerland
    • Bombeli, T.. Institute of Anaesthesiology, University Hospital Zurich, Switzerland. Department of Biostatistics, University of Zurich, Switzerland. Division of Haematology, Department of Internal Medicine, University Hospital Zurich, Switzerland.*Corresponding author: Institute of Anaesthesiology, University Hospital, Raemistrasse 100, CH‐8091 Zürich, Switzerland
    • Zalunardo, M. P.. Institute of Anaesthesiology, University Hospital Zurich, Switzerland. Department of Biostatistics, University of Zurich, Switzerland. Division of Haematology, Department of Internal Medicine, University Hospital Zurich, Switzerland.*Corresponding author: Institute of Anaesthesiology, University Hospital, Raemistrasse 100, CH‐8091 Zürich, Switzerland
    • Pasch, T.. Institute of Anaesthesiology, University Hospital Zurich, Switzerland. Department of Biostatistics, University of Zurich, Switzerland. Division of Haematology, Department of Internal Medicine, University Hospital Zurich, Switzerland.*Corresponding author: Institute of Anaesthesiology, University Hospital, Raemistrasse 100, CH‐8091 Zürich, Switzerland
    • Spahn, D. R.. Institute of Anaesthesiology, University Hospital Zurich, Switzerland. Department of Biostatistics, University of Zurich, Switzerland. Division of Haematology, Department of Internal Medicine, University Hospital Zurich, Switzerland.*Corresponding author: Institute of Anaesthesiology, University Hospital, Raemistrasse 100, CH‐8091 Zürich, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • British Journal of Anaesthesia, 2001, vol. 87, no. 2, p. 246-249. Oxford University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:296295
    Summary
    Low haematocrit values are generally well tolerated in terms of oxygen transport but a low haematocrit might interfere with blood coagulation. We thus sampled 60 ml of blood in 30 healthy volunteers. The blood was centrifuged for 30 min at 2000 g and separated into plasma, which contained the platelet fraction, and packed red blood cells. The blood was subsequently reconstituted by combining the entire plasma fraction with a mixture of packed red blood cells, 0.9% saline, so that the final haematocrit was either 40, 30, 20, or 10%. Blood coagulation was assessed by computerized Thrombelastograph® analysis. Data were compared using repeated measures analysis of variance and post‐hoc paired t‐tests with Bonferroni correction. Decreasing the haematocrit from 40 to 10% resulted in a shortening of reaction time (r) and coagulation time (k), and an increase in angle α, maximum amplitude (MA) and clot strength (G) (all P<0.02). This pattern represents acceleration of blood coagulation with low haematocrit values. The isolated reduction in haematocrit, therefore, does not compromise in vitro blood coagulation. Br J Anaesth 2001; 87: 246-9