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THE VALUE OF ISOTYPE DETERMINATION OF SERUM ANTIBODIES AGAINST CHLAMYDIA FOR THE DIAGNOSIS OF CHLAMYDIA REACTIVE ARTHRITIS

BAS, S. ; CUNNINGHAM, T. ; KVIEN, T. K. ; GIENNÅS, A. ; MELBY, K. ; VISCHER, T. L.

In: Rheumatology, 1996, vol. 35, no. 6, p. 542-547

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    Titre
    • THE VALUE OF ISOTYPE DETERMINATION OF SERUM ANTIBODIES AGAINST CHLAMYDIA FOR THE DIAGNOSIS OF CHLAMYDIA REACTIVE ARTHRITIS
    Auteur
    • BAS, S.. Division of Rheumatology, University Hospital Geneva, Switzerland
    • CUNNINGHAM, T.. Division of Rheumatology, University Hospital Geneva, Switzerland
    • KVIEN, T. K.. Oslo City Department of Rheumatology, Norwegian Lutheran Hospital Oslo
    • GIENNÅS, A.. Oslo City Department of Rheumatology, Norwegian Lutheran Hospital Oslo
    • MELBY, K.. Department of Microbiology, Ullevàl University Hospital Oslo, Norway
    • VISCHER, T. L.. Division of Rheumatology, University Hospital Geneva, Switzerland
    Type de document
    • Postprint
    Identifiant OAI-PMH
    • oai:doc.rero.ch:295904
    Summary
    SUMMARY In clinical rheumatology, the diagnosis of Chlamydia reactive arthritis is difficult because an incomplete form of the disease can closely resemble an undifferentiated seronegative mono/oligoarthritis. We investigated whether measuring specific isotypes of anti-Chlamydia antibodies in serum can improve the diagnosis, by comparing such antibody concentrations in the serum of patients with well-defined disease, i.e. Chlamydia trachomatis sexually acquired reactive arthritis (CT-SARA), with other arthritides. Antibody levels were determined by enzyme-linked immunosorbent assay (ELISA). When considering two different isotypes and their combination, the best sensitivity (63%) was obtained for IgM and/or IgA results with a specificity of 81%. The patients with CT-SARA and SARA had the highest levels of antibodies of all isotypes tested. It is concluded that, in our experimental conditions, only very high values of specific isotypes could indicate a diagnosis of Chlamydia reactive arthritis