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Evaluation of role of concentration and molecular weight of oat β-glucan in determining effect of viscosity on plasma glucose and insulin following an oral glucose load

Wood, P. J. ; Beer, M. U. ; Butler, G.

In: British Journal of Nutrition, 2000, vol. 84, no. 1, p. 19-23

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    Title
    • Evaluation of role of concentration and molecular weight of oat β-glucan in determining effect of viscosity on plasma glucose and insulin following an oral glucose load
    Author
    • Wood, P. J.. Agriculture and Agri-Food Canada, Southern Crop Protection and Food Research Centre, 93 Stone Road West, Guelph, Ontario, N1G 2W1, Canada
    • Beer, M. U.. Novartis Nutrition Research AG, CH-3176, Neuenegg, Switzerland
    • Butler, G.. Agriculture and Agri-Food Canada, Eastern Cereal and Oilseed Research Centre, Ottawa, Ontario, K1A 0C6, Canada
    Document Type
    • Postprint
    OAI-PMH Identifier
    • oai:doc.rero.ch:295893
    Summary
    Data from clinical studies established that there was an inverse linear relationship between measures of postprandial blood glucose and insulin responses to an oral glucose load, consumed in a drink, and the logarithm of viscosity of the drink. These data have been re-analysed using concentration and molecular weight as the dependent variables. Molecular weight (M) of the β-glucans used was determined using high-performance size exclusion chromatography equipped with a triple detector system of right angle light scattering, viscometry and refractive index. A significant relationship between changes in peak blood glucose and a combination of logarithm of the concentration and logarithm of M was found