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A patient with SLE-associated thrombotic microangiopathy and non-neutralizing antibodies against ADAMTS13

Knecht, Margrith E. ; Mayr, Michael ; Ferrari, Silvia ; Scheiflinger, Friedrich ; Trendelenburg, Marten

In: Nephrology Dialysis Transplantation, 2010, vol. 25, no. 5, p. 1720-1722

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    Titre
    • A patient with SLE-associated thrombotic microangiopathy and non-neutralizing antibodies against ADAMTS13
    Auteur
    • Knecht, Margrith E.. Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
    • Mayr, Michael. Clinic for Transplantation Immunology and Nephrology, Medical Outpatient Department, University Hospital Basel, Basel, Switzerland
    • Ferrari, Silvia. Discovery Research & Technical Assessment, BioPharmaceuticals, R&D, Baxter Innovations GmbH, Vienna, Austria
    • Scheiflinger, Friedrich. Discovery Research & Technical Assessment, BioPharmaceuticals, R&D, Baxter Innovations GmbH, Vienna, Austria
    • Trendelenburg, Marten. Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Nephrology Dialysis Transplantation, 2010, vol. 25, no. 5, p. 1720-1722. Oxford University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:295684
    Summary
    In this case report, we describe for the first time a patient with thrombotic thrombocytopaenic purpura (TTP) accompanying highly active systemic lupus erythematosus (SLE) that was associated with non-neutralizing antibodies against the plasma metalloprotease ADAMTS13. Those non-neutralizing antibodies could have been the cause of ADAMTS13 depletion and consecutive TTP. More extensive analyses are required to determine the prevalence as well as the clinical relevance of non-neutralizing antibodies against ADAMTS13 in SLE patients