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Pharmacokinetics of long half-life antibacterials

Follath, F.

In: Journal of Antimicrobial Chemotherapy, 1979, vol. 5, no. Supplement_B, p. 97-102

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    Titre
    • Pharmacokinetics of long half-life antibacterials
    Auteur
    • Follath, F.. Clinical Pharmacology Division, Department of Medicine, Kantonsspital Basel, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Journal of Antimicrobial Chemotherapy, 1979, vol. 5, no. Supplement_B, p. 97-102. Oxford University Press
    Autre version électronique
    Classification
    • Santé
    Identifiant OAI-PMH
    • oai:doc.rero.ch:295417
    Summary
    Trimethoprim (TMP), sulfamethoxazole (SMZ) and sulfadiazine (SDZ) are characterized by elimination half-lives of 9 to 15 h. Effective serum concentrations can therefore be maintained by twice daily administration, but without a loading dose steady state levels will be reached only after 3 days. Renal disease has little effect on the pharmacokinetics of unchanged SMZ, whereas TMP and SDZ elimination is prolonged in uremia. Dosage adaptation to creatinine clearance is difficult, since the ratio of the two components in serum and urine will be altered. Abnormal drug accumulation in liver disease during a treatment with TMP and SMZ has not been demonstrated