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Updates in perioperative coagulation: physiology and management of thromboembolism and haemorrhage

Bombeli, T. ; Spahn, D. R.

In: British Journal of Anaesthesia, 2004, vol. 93, no. 2, p. 275-287

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    Title
    • Updates in perioperative coagulation: physiology and management of thromboembolism and haemorrhage
    Author
    • Bombeli, T.. Coagulation Laboratory, Division of Haematology, University Hospital of Zürich, Sternwartstrasse 14, CH-8091 Zürich, Switzerland.
    • Spahn, D. R.. Department of Anaesthesiology, University Hospital of Lausanne, Rue du Bugnon 46, CH-1011 Lausanne, Switzerland
    Document Type
    • Postprint
    Language
    • English
    Published in
    • British Journal of Anaesthesia, 2004, vol. 93, no. 2, p. 275-287. Oxford University Press
    Other Version
    OAI-PMH Identifier
    • oai:doc.rero.ch:295168
    Summary
    Understanding of blood coagulation has evolved significantly in recent years. Both new coagulation proteins and inhibitors have been found and new interactions among previously known components of the coagulation system have been discovered. This increased knowledge has led to the development of various new diagnostic coagulation tests and promising antithrombotic and haemostatic drugs. Several such agents are currently being introduced into clinical medicine for both the treatment or prophylaxis of thromboembolic disease and for the treatment of bleeding. This review aims to elucidate these new concepts and to outline some consequences for clinical anaesthesia and perioperative medicine