Fulltext

Malaria and soil-transmitted intestinal helminth co-infection and its effect on anemia: a meta-analysis

Naing, Cho ; Whittaker, Maxine A. ; Nyunt-Wai, Victor ; Reid, Simon A. ; Wong, Shew Fung ; Mak, Joon Wah ; Tanner, Marcel

In: Transactions of The Royal Society of Tropical Medicine and Hygiene, 2013, vol. 107, no. 11, p. 672-683

Zum persönliche Liste hinzufügen
    Titel
    • Malaria and soil-transmitted intestinal helminth co-infection and its effect on anemia: a meta-analysis
    Autor
    • Naing, Cho. School of Population Health, University of Queensland, Queensland 4006, Australia
    • Whittaker, Maxine A.. School of Population Health, University of Queensland, Queensland 4006, Australia
    • Nyunt-Wai, Victor. International Medical University, Kuala Lumpur 57000, Malaysia
    • Reid, Simon A.. School of Population Health, University of Queensland, Queensland 4006, Australia
    • Wong, Shew Fung. International Medical University, Kuala Lumpur 57000, Malaysia
    • Mak, Joon Wah. International Medical University, Kuala Lumpur 57000, Malaysia
    • Tanner, Marcel. Swiss Tropical and Public Health Institute, Basel 4002, Switzerland
    Dokumententyp
    • Postprint
    Sprache
    • Englisch
    Veröffentlicht in
    • Transactions of The Royal Society of Tropical Medicine and Hygiene, 2013, vol. 107, no. 11, p. 672-683. Oxford University Press
    Andere elektronische Ausgabe
    OAI-PMH-ID
    • oai:doc.rero.ch:295130
    Summary
    This study aimed to synthesize available evidence on the extent of malaria and soil-transmitted intestinal helminth (STH) co-infections in people living in endemic countries and to explore the effect of interactions between malaria and STHs on anemia. We searched relevant studies in electronic databases up to March 2013. Studies comparing malaria and STH co-infected patients with those not co-infected were included and the effect estimates were pooled using a random-effects model. We identified 30 studies for meta-analyses of which 17 were cross-sectional design. The majority of included studies (80%) were carried out in African countries. Among pregnant women, those infected with hookworm were found to have higher association with malaria infection compared with those without (summary OR: 1.36; 95% CI: 1.17-1.59; I2: 0%). Among non-pregnant adults, the summary OR of the association between anemia and the combined malaria and STH was 2.91 (1.38-6.14). The summary OR of the association between anemia and malaria alone was 1.53 (0.97-2.42), while the association between anemia and STH alone was 0.28 (0.04-1.95). There is no good evidence to support a different effect of malaria and STH on anemia. A subgroup analysis showed a higher risk of malaria infection in the primigravidae (summary OR: 1.61; 95% CI: 1.3-1.99; I2: 0%). In conclusion, the malaria-STH co-infection was variable with complex outcomes on anemia