Fulltext

Effect of 3-aminobenzamide on chromosome damage in human blood lymphocytes adapted to bleomycin

Vijayalaxmi ; Burkart, W.

In: Mutagenesis, 1989, vol. 4, no. 3, p. 187-189

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    Titel
    • Effect of 3-aminobenzamide on chromosome damage in human blood lymphocytes adapted to bleomycin
    Autor
    • Vijayalaxmi. Radiation Biology Unit, Paul Scherrer Institute, CH-5303 Wurenlingen, Switzerland
    • Burkart, W.. Radiation Biology Unit, Paul Scherrer Institute, CH-5303 Wurenlingen, Switzerland
    Dokumententyp
    • Postprint
    Sprache
    • Englisch
    Veröffentlicht in
    • Mutagenesis, 1989, vol. 4, no. 3, p. 187-189. Oxford University Press
    Andere elektronische Ausgabe
    OAI-PMH-ID
    • oai:doc.rero.ch:295111
    Summary
    Human blood lymphocytes, pre-treated with very low (adaptation) concentrations of bleomycin for 48 h and then exposed to a high (challenge) dose of the same agent or X-rays, became significantly less sensitive to the induction of chromosome damage than those which did not receive the pre-treatment, indicating an induction of ‘adaptive repair' process. This repair process was negated when 3-amino-benzainide, an inhibitor of poly (ADP) polymerase, was added to the cultures immediately after the challenge treatment. The magnitude of negation in the adaptation response was greater in the case of lymphocytes challenged with X-rays as compared with those challenged with bleomycin