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Remifentanil inhibits muscular more than cutaneous pain in humans

Curatolo, M. ; Petersen‐Felix, S. ; Gerber, A. ; Arendt‐Nielsen, L.

In: British Journal of Anaesthesia, 2000, vol. 85, no. 4, p. 529-532

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    Titre
    • Remifentanil inhibits muscular more than cutaneous pain in humans
    Auteur
    • Curatolo, M.. Department of Anaesthesiology, Division of Pain Therapy, University Hospital of Bern, Inselspital, CH‐3010 Bern, Switzerland. Department of Anaesthesiology, Division of Obstetrical Anaesthesia, University Hospital of Bern, Inselspital, CH‐3010 Bern, Switzerland. Center for Sensory-Motor Interaction, Laboratory for Experimental Pain Research, University of Aalborg, Fr. Bajers Vej 7D, DK‐9220 Aalborg, Denmark
    • Petersen‐Felix, S.. Department of Anaesthesiology, Division of Pain Therapy, University Hospital of Bern, Inselspital, CH‐3010 Bern, Switzerland. Department of Anaesthesiology, Division of Obstetrical Anaesthesia, University Hospital of Bern, Inselspital, CH‐3010 Bern, Switzerland. Center for Sensory-Motor Interaction, Laboratory for Experimental Pain Research, University of Aalborg, Fr. Bajers Vej 7D, DK‐9220 Aalborg, Denmark
    • Gerber, A.. Department of Anaesthesiology, Division of Pain Therapy, University Hospital of Bern, Inselspital, CH‐3010 Bern, Switzerland. Department of Anaesthesiology, Division of Obstetrical Anaesthesia, University Hospital of Bern, Inselspital, CH‐3010 Bern, Switzerland. Center for Sensory-Motor Interaction, Laboratory for Experimental Pain Research, University of Aalborg, Fr. Bajers Vej 7D, DK‐9220 Aalborg, Denmark
    • Arendt‐Nielsen, L.. Department of Anaesthesiology, Division of Pain Therapy, University Hospital of Bern, Inselspital, CH‐3010 Bern, Switzerland. Department of Anaesthesiology, Division of Obstetrical Anaesthesia, University Hospital of Bern, Inselspital, CH‐3010 Bern, Switzerland. Center for Sensory-Motor Interaction, Laboratory for Experimental Pain Research, University of Aalborg, Fr. Bajers Vej 7D, DK‐9220 Aalborg, Denmark
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • British Journal of Anaesthesia, 2000, vol. 85, no. 4, p. 529-532. Oxford University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:294748
    Summary
    In experimental studies, drug‐induced analgesia is usually assessed by cutaneous stimulation. If analgesics act differently on cutaneous and deep nociception, the results of these studies may not be entirely applicable to clinical pain involving deep structures. We tested the hypothesis that opioids have different abilities to inhibit cutaneous and muscular pain. Either the opioid remifentanil or placebo was infused in 12 healthy volunteers in a cross‐over fashion. Repeated electrical stimulation (five impulses at 2Hz) was applied to both skin and muscle. Pain thresholds were recorded. Remifentanil caused a higher increase in the muscular pain thresholds than in the cutaneous pain thresholds (P=0.035). We conclude that opioids inhibit muscular pain more strongly than cutaneous pain in humans. Br J Anaesth 2000; 85: 529-32