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Individualized differential diagnosis of schizophrenia and mood disorders using neuroanatomical biomarkers

Koutsouleris, Nikolaos ; Meisenzahl, Eva M. ; Borgwardt, Stefan ; Riecher-Rössler, Anita ; Frodl, Thomas ; Kambeitz, Joseph ; Köhler, Yanis ; Falkai, Peter ; Möller, Hans-Jürgen ; Reiser, Maximilian ; Davatzikos, Christos

In: Brain, 2015, vol. 138, no. 7, p. 2059-2073

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    Titre
    • Individualized differential diagnosis of schizophrenia and mood disorders using neuroanatomical biomarkers
    Auteur
    • Koutsouleris, Nikolaos. 1 Department of Psychiatry and Psychotherapy, Ludwig-Maximilian-University, Germany
    • Meisenzahl, Eva M.. 1 Department of Psychiatry and Psychotherapy, Ludwig-Maximilian-University, Germany
    • Borgwardt, Stefan. 2 Department of Psychiatry, University of Basel, Switzerland
    • Riecher-Rössler, Anita. 2 Department of Psychiatry, University of Basel, Switzerland
    • Frodl, Thomas. 1 Department of Psychiatry and Psychotherapy, Ludwig-Maximilian-University, Germany
    • Kambeitz, Joseph. 1 Department of Psychiatry and Psychotherapy, Ludwig-Maximilian-University, Germany
    • Köhler, Yanis. 1 Department of Psychiatry and Psychotherapy, Ludwig-Maximilian-University, Germany
    • Falkai, Peter. 2 Department of Psychiatry, University of Basel, Switzerland
    • Möller, Hans-Jürgen. 1 Department of Psychiatry and Psychotherapy, Ludwig-Maximilian-University, Germany
    • Reiser, Maximilian. 5 Department of Radiology, Ludwig-Maximilian-University, Munich, Germany
    • Davatzikos, Christos. 6 Section of Biomedical Image Analysis, Department of Radiology, University of Pennsylvania, USA
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Brain, 2015, vol. 138, no. 7, p. 2059-2073. Oxford University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:294698
    Summary
    MRI-based markers can distinguish patients with schizophrenia from healthy controls. Koutsouleris et al. now report a diagnostic signature that distinguishes major depression/bipolar disorder from schizophrenia in 80%/74% of cases. Classification accuracy generalizes to early phases of psychosis, and is moderated by disease stage, age of onset and accelerated brain ageing