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Compartmentalization of Cells Bearing "Rheumatic” Cell Surface Antigens in Peripheral Blood and Tonsils in Rheumatic Heart Disease

Gray, E. D. ; Regelmann, W. E. ; Abdin, Z. ; Kholy, A. EI ; Zaher, S. ; Kamel, R. ; Mansour, M. ; Miller, L. ; Ferrieri, P. ; Zabriskie, J. B. ; Braun, D.

In: Journal of Infectious Diseases, 1987, vol. 155, no. 2, p. 247-252

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    Title
    • Compartmentalization of Cells Bearing "Rheumatic” Cell Surface Antigens in Peripheral Blood and Tonsils in Rheumatic Heart Disease
    Author
    • Gray, E. D.. Departments of Pediatrics, Biochemistry, and Laboratory Medicine/Pathology, University of Minnesota Medical School, Minneapolis, Minnesota, Cairo, Egypt, New York, New York, Ciba-Geigy, Basel, Switzerland
    • Regelmann, W. E.. Departments of Pediatrics, Biochemistry, and Laboratory Medicine/Pathology, University of Minnesota Medical School, Minneapolis, Minnesota, Cairo, Egypt, New York, New York, Ciba-Geigy, Basel, Switzerland
    • Abdin, Z.. Departments of Pediatrics, Biochemistry, and Laboratory Medicine/Pathology, University of Minnesota Medical School, Minneapolis, Minnesota, Cairo, Egypt, New York, New York, Ciba-Geigy, Basel, Switzerland
    • Kholy, A. EI. Departments of Pediatrics, Biochemistry, and Laboratory Medicine/Pathology, University of Minnesota Medical School, Minneapolis, Minnesota, Cairo, Egypt, New York, New York, Ciba-Geigy, Basel, Switzerland
    • Zaher, S.. Departments of Pediatrics, Biochemistry, and Laboratory Medicine/Pathology, University of Minnesota Medical School, Minneapolis, Minnesota, Cairo, Egypt, New York, New York, Ciba-Geigy, Basel, Switzerland
    • Kamel, R.. Departments of Pediatrics, Biochemistry, and Laboratory Medicine/Pathology, University of Minnesota Medical School, Minneapolis, Minnesota, Cairo, Egypt, New York, New York, Ciba-Geigy, Basel, Switzerland
    • Mansour, M.. Departments of Pediatrics, Biochemistry, and Laboratory Medicine/Pathology, University of Minnesota Medical School, Minneapolis, Minnesota, Cairo, Egypt, New York, New York, Ciba-Geigy, Basel, Switzerland
    • Miller, L.. Departments of Pediatrics, Biochemistry, and Laboratory Medicine/Pathology, University of Minnesota Medical School, Minneapolis, Minnesota, Cairo, Egypt, New York, New York, Ciba-Geigy, Basel, Switzerland
    • Ferrieri, P.. Departments of Pediatrics, Biochemistry, and Laboratory Medicine/Pathology, University of Minnesota Medical School, Minneapolis, Minnesota, Cairo, Egypt, New York, New York, Ciba-Geigy, Basel, Switzerland
    • Zabriskie, J. B.. Departments of Pediatrics, Biochemistry, and Laboratory Medicine/Pathology, University of Minnesota Medical School, Minneapolis, Minnesota, Cairo, Egypt, New York, New York, Ciba-Geigy, Basel, Switzerland
    • Braun, D.. Departments of Pediatrics, Biochemistry, and Laboratory Medicine/Pathology, University of Minnesota Medical School, Minneapolis, Minnesota, Cairo, Egypt, New York, New York, Ciba-Geigy, Basel, Switzerland
    Document Type
    • Postprint
    Language
    • English
    Published in
    • Journal of Infectious Diseases, 1987, vol. 155, no. 2, p. 247-252. The University of Chicago Press
    Other Version
    Classification
    • Health
    OAI-PMH Identifier
    • oai:doc.rero.ch:294602
    Summary
    Monoclonal antibodies that recognize "rheumatic” antigens of peripheral blood non-T cells were used to study the compartmentalization of such cells in peripheral blood and tonsils of individuals with rheumatic heart disease (RHD) and suitable control subjects. The peripheral blood of most (71%) of the 42 individuals with RHD contained cells reacting with monoclonal antibody 83S19.23 or 256S.10, whereas these cells were present in only 17% of the 41 control subjects (P < .02). However, none of 21 individuals with RHD had such cells in their tonsils, although they were present in the tonsils of 50% of the 40 control subjects (P < .03). These results may reflect a failure in RHD of organ-specific homing of cells with the epitopes recognized by the antibodies. The presence of these cells in tonsils may be important in the immune response to streptococcal pharyngeal infection, and their absence in RHD may be involved in the unusual immune responses characteristic of this disease