Fulltext

Serial changes in cardiovascular and renal function of rabbits ingesting a high-fat, high-calorie diet

Antic, Vladan ; Tempini, Aldo ; Montani, Jean-Pierre

In: American Journal of Hypertension, 1999, vol. 12, no. 8, p. 826-829

Ajouter à la liste personnelle
    Titre
    • Serial changes in cardiovascular and renal function of rabbits ingesting a high-fat, high-calorie diet
    Auteur
    • Antic, Vladan. Institute of Physiology, University of Fribourg, Fribourg, Switzerland
    • Tempini, Aldo. Institute of Physiology, University of Fribourg, Fribourg, Switzerland
    • Montani, Jean-Pierre. Institute of Physiology, University of Fribourg, Fribourg, Switzerland
    Type de document
    • Postprint
    Identifiant OAI-PMH
    • oai:doc.rero.ch:294444
    Summary
    To explore the mechanisms of obesity-induced hypertension we analyzed the sequential changes in cardiovascular and renal function in adult rabbits switched to high-fat diet (HFD) for 8 weeks. Animals were housed in metabolic cages for continuous 24-h recording of arterial pressure by telemetry and daily urine collection. High-fat diet induced a progressive increase in body weight (+47%) and a rapid rise in mean arterial pressure, heart rate, and glomerular filtration rate that stabilized, respectively, at 14%, 31% and 68% greater than control values. Time-course analysis of changes in blood pressure may reveal two components of obesity-induced hypertension, an early phase related to HFD itself and a later phase related to weight gain. Am J Hypertens 1999;12:826-829 © 1999 American Journal of Hypertension, Ltd