Fulltext

Efficacy of gatifloxacin alone and in combination with cefepime against penicillin-resistant Streptococcus pneumoniae in a rabbit meningitis model and in vitro

Perrig, Martin ; Acosta, Fernando ; Cottagnoud, Marianne ; Gerber, Cynthia M. ; Täuber, Martin G. ; Cottagnoud, Philippe

In: Journal of Antimicrobial Chemotherapy, 2001, vol. 47, no. 5, p. 701-704

Ajouter à la liste personnelle
    Titre
    • Efficacy of gatifloxacin alone and in combination with cefepime against penicillin-resistant Streptococcus pneumoniae in a rabbit meningitis model and in vitro
    Auteur
    • Perrig, Martin. Department of Internal Medicine, Zieglerspital, 3007 Berne
    • Acosta, Fernando. Department of Internal Medicine, Zieglerspital, 3007 Berne
    • Cottagnoud, Marianne. Department of Internal Medicine, Zieglerspital, 3007 Berne
    • Gerber, Cynthia M.. Department of Internal Medicine, Zieglerspital, 3007 Berne
    • Täuber, Martin G.. Institute of Medical Microbiology, University of Berne
    • Cottagnoud, Philippe. Department of Internal Medicine, Inselspital, 3010 Berne, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Journal of Antimicrobial Chemotherapy, 2001, vol. 47, no. 5, p. 701-704. Oxford University Press
    Autre version électronique
    Classification
    • Santé
    Identifiant OAI-PMH
    • oai:doc.rero.ch:294393
    Summary
    Gatifloxacin penetrated well into cerebrospinal fluid (CSF) (49 ± 11%), measured by comparison of AUCCSF/AUCserum, and showed good bactericidal activity (leading to a decrease of 0.75 ± 0.17 log10 cfu/mL/h) in the treatment of experimental meningitis in rabbits caused by a penicillin-resistant pneumococcal strain (MIC 4 mg/L). It was significantly more effective than the standard regimen, ceftriaxone with vancomycin, which led to a decrease of 0.53 ± 0.17 log10 cfu/mL/h. The addition of cefepime to gatifloxacin slightly improved the killing rates (giving a decrease of 0.84 ± 0.14 log10 cfu/mL/h). In vitro, synergy was demonstrated between cefepime and gatifloxacin by the chequerboard method (fractional inhibitory concentration index = 0.5) and by viable counts over 8 h