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Intestinal Infection Due to Enteroaggregative Eschevichia coli among Human Immunodeficiency Virus—Infected Persons

Durrer, Petra ; Zbinden, Reinhard ; Fleisch, Felix ; Altwegg, Martin ; Ledergerber, Bruno ; Karch, Helge ; Weber, Rainer

In: The Journal of Infectious Diseases, 2000, vol. 182, no. 5, p. 1540-1544

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    Titel
    • Intestinal Infection Due to Enteroaggregative Eschevichia coli among Human Immunodeficiency Virus—Infected Persons
    Autor
    • Durrer, Petra. Division of Infectious Diseases and Hospital Epidemiology, Department of Medicine, University of Zurich, Zurich, Switzerland
    • Zbinden, Reinhard. Department of Medical Microbiology, University of Zurich, Zurich, Switzerland
    • Fleisch, Felix. Division of Infectious Diseases and Hospital Epidemiology, Department of Medicine, University of Zurich, Zurich, Switzerland
    • Altwegg, Martin. Department of Medical Microbiology, University of Zurich, Zurich, Switzerland
    • Ledergerber, Bruno. Division of Infectious Diseases and Hospital Epidemiology, Department of Medicine, University of Zurich, Zurich, Switzerland
    • Karch, Helge. Institute of Hospital Epidemiology and Microbiology, University of Würzburg, Würzburg, Germany
    • Weber, Rainer. Division of Infectious Diseases and Hospital Epidemiology, Department of Medicine, University of Zurich, Zurich, Switzerland
    Dokumententyp
    • Postprint
    Sprache
    • Englisch
    Veröffentlicht in
    • The Journal of Infectious Diseases, 2000, vol. 182, no. 5, p. 1540-1544. The University of Chicago Press
    Andere elektronische Ausgabe
    Klassifikation
    • Gesundheit
    OAI-PMH-ID
    • oai:doc.rero.ch:294247
    Summary
    To investigate the pathogenic role of enteroaggregative Escherichia coli (EAggEC) among human immunodeficiency virus—infected persons, 111 outpatients with and 68 without diarrhea were evaluated. Examination of stool samples included the HeLa cell adherence assay and an EAggEC polymerase chain reaction (PCR) assay using primers complementary for the plasmid locus CVD432. The pCVD432 genotype, adherence phenotype, and patient characteristics were correlated with occurrence of diarrhea by multivariate analyses. EAggEC PCR and adherence assays were positive in 7 (6%) and 24 (22%) patients with diarrhea and in 1 (1%) and 21 (31%) asymptomatic control patients, respectively. Clinical manifestations associated with EAggEC PCR-positive isolates were nonspecific; EAggEC infections were independent of CD4 lymphocyte counts. Of the pCVD432 genotype, 5 (71%) of 7 were resistant to cotrimoxazole and ampicillin, and 1 strain was resistant to ciprofloxacin. Overall, pCVD432 PCR-positive E. coli was the most prevalent intestinal organism associated with diarrhea. The adherence assay results did not correlate with diarrhea