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ELM—the database of eukaryotic linear motifs

Dinkel, Holger ; Michael, Sushama ; Weatheritt, Robert J. ; Davey, Norman E. ; Van Roey, Kim ; Altenberg, Brigitte ; Toedt, Grischa ; Uyar, Bora ; Seiler, Markus ; Budd, Aidan ; Jödicke, Lisa ; Dammert, Marcel A. ; Schroeter, Christian ; Hammer, Maria ; Schmidt, Tobias ; Jehl, Peter ; McGuigan, Caroline ; Dymecka, Magdalena ; Chica, Claudia ; Luck, Katja ; Via, Allegra ; Chatr-aryamontri, Andrew ; Haslam, Niall ; Grebnev, Gleb ; Edwards, Richard J. ; Steinmetz, Michel O. ; Meiselbach, Heike ; Diella, Francesca ; Gibson, Toby J.

In: Nucleic Acids Research, 2012, vol. 40, no. D1, p. D242-D251

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    Title
    • ELM—the database of eukaryotic linear motifs
    Author
    • Dinkel, Holger. Structural and Computational Biology, European Molecular Biology Laboratory, Heidelberg, Germany, Laboratory of Bioinformatics and Systems Biology, M. Sklodowska-Curie Cancer Center and Institute of Oncology, WK Roentgena 5, 02-781 Warsaw, Poland, Genoscope (CEA - Institut de Génomique), 2 rue Gaston Cremieux CP5706, 91057 Evry, Group Oncoproteins, Unité CNRS-UDS UMR 7242, Institut de Recherche de l'Ecole de Biotechnologie de Strasbourg, 1, Bd Sébastien Brant, BP 10413, 67412 Illkirch - Cedex, France, Biocomputing Group, Department of Physics, Sapienza University of Rome, P.le Aldo Moro 5, Rome, Italy, School of Biological Sciences, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, UK, School of Medicine and Medical Science, University College, Dublin, Ireland, Centre for Biological Sciences, Institute for Life Sciences, University of Southampton, UK, Biomolecular Research, Paul Scherrer Institut, CH-5232 Villigen PSI, Switzerland, Bioinformatik, Institut für Biochemie, Friedrich-Alexander-Universität, Fahrstraße 17, 91054 Erlangen-Nürnberg and Molecular Health GmbH Belfortstr. 2, 69115 Heidelberg, Germany
    • Michael, Sushama. Structural and Computational Biology, European Molecular Biology Laboratory, Heidelberg, Germany, Laboratory of Bioinformatics and Systems Biology, M. Sklodowska-Curie Cancer Center and Institute of Oncology, WK Roentgena 5, 02-781 Warsaw, Poland, Genoscope (CEA - Institut de Génomique), 2 rue Gaston Cremieux CP5706, 91057 Evry, Group Oncoproteins, Unité CNRS-UDS UMR 7242, Institut de Recherche de l'Ecole de Biotechnologie de Strasbourg, 1, Bd Sébastien Brant, BP 10413, 67412 Illkirch - Cedex, France, Biocomputing Group, Department of Physics, Sapienza University of Rome, P.le Aldo Moro 5, Rome, Italy, School of Biological Sciences, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, UK, School of Medicine and Medical Science, University College, Dublin, Ireland, Centre for Biological Sciences, Institute for Life Sciences, University of Southampton, UK, Biomolecular Research, Paul Scherrer Institut, CH-5232 Villigen PSI, Switzerland, Bioinformatik, Institut für Biochemie, Friedrich-Alexander-Universität, Fahrstraße 17, 91054 Erlangen-Nürnberg and Molecular Health GmbH Belfortstr. 2, 69115 Heidelberg, Germany
    • Weatheritt, Robert J.. Structural and Computational Biology, European Molecular Biology Laboratory, Heidelberg, Germany, Laboratory of Bioinformatics and Systems Biology, M. Sklodowska-Curie Cancer Center and Institute of Oncology, WK Roentgena 5, 02-781 Warsaw, Poland, Genoscope (CEA - Institut de Génomique), 2 rue Gaston Cremieux CP5706, 91057 Evry, Group Oncoproteins, Unité CNRS-UDS UMR 7242, Institut de Recherche de l'Ecole de Biotechnologie de Strasbourg, 1, Bd Sébastien Brant, BP 10413, 67412 Illkirch - Cedex, France, Biocomputing Group, Department of Physics, Sapienza University of Rome, P.le Aldo Moro 5, Rome, Italy, School of Biological Sciences, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, UK, School of Medicine and Medical Science, University College, Dublin, Ireland, Centre for Biological Sciences, Institute for Life Sciences, University of Southampton, UK, Biomolecular Research, Paul Scherrer Institut, CH-5232 Villigen PSI, Switzerland, Bioinformatik, Institut für Biochemie, Friedrich-Alexander-Universität, Fahrstraße 17, 91054 Erlangen-Nürnberg and Molecular Health GmbH Belfortstr. 2, 69115 Heidelberg, Germany
    • Davey, Norman E.. Structural and Computational Biology, European Molecular Biology Laboratory, Heidelberg, Germany, Laboratory of Bioinformatics and Systems Biology, M. Sklodowska-Curie Cancer Center and Institute of Oncology, WK Roentgena 5, 02-781 Warsaw, Poland, Genoscope (CEA - Institut de Génomique), 2 rue Gaston Cremieux CP5706, 91057 Evry, Group Oncoproteins, Unité CNRS-UDS UMR 7242, Institut de Recherche de l'Ecole de Biotechnologie de Strasbourg, 1, Bd Sébastien Brant, BP 10413, 67412 Illkirch - Cedex, France, Biocomputing Group, Department of Physics, Sapienza University of Rome, P.le Aldo Moro 5, Rome, Italy, School of Biological Sciences, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, UK, School of Medicine and Medical Science, University College, Dublin, Ireland, Centre for Biological Sciences, Institute for Life Sciences, University of Southampton, UK, Biomolecular Research, Paul Scherrer Institut, CH-5232 Villigen PSI, Switzerland, Bioinformatik, Institut für Biochemie, Friedrich-Alexander-Universität, Fahrstraße 17, 91054 Erlangen-Nürnberg and Molecular Health GmbH Belfortstr. 2, 69115 Heidelberg, Germany
    • Van Roey, Kim. Structural and Computational Biology, European Molecular Biology Laboratory, Heidelberg, Germany, Laboratory of Bioinformatics and Systems Biology, M. Sklodowska-Curie Cancer Center and Institute of Oncology, WK Roentgena 5, 02-781 Warsaw, Poland, Genoscope (CEA - Institut de Génomique), 2 rue Gaston Cremieux CP5706, 91057 Evry, Group Oncoproteins, Unité CNRS-UDS UMR 7242, Institut de Recherche de l'Ecole de Biotechnologie de Strasbourg, 1, Bd Sébastien Brant, BP 10413, 67412 Illkirch - Cedex, France, Biocomputing Group, Department of Physics, Sapienza University of Rome, P.le Aldo Moro 5, Rome, Italy, School of Biological Sciences, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, UK, School of Medicine and Medical Science, University College, Dublin, Ireland, Centre for Biological Sciences, Institute for Life Sciences, University of Southampton, UK, Biomolecular Research, Paul Scherrer Institut, CH-5232 Villigen PSI, Switzerland, Bioinformatik, Institut für Biochemie, Friedrich-Alexander-Universität, Fahrstraße 17, 91054 Erlangen-Nürnberg and Molecular Health GmbH Belfortstr. 2, 69115 Heidelberg, Germany
    • Altenberg, Brigitte. Structural and Computational Biology, European Molecular Biology Laboratory, Heidelberg, Germany, Laboratory of Bioinformatics and Systems Biology, M. Sklodowska-Curie Cancer Center and Institute of Oncology, WK Roentgena 5, 02-781 Warsaw, Poland, Genoscope (CEA - Institut de Génomique), 2 rue Gaston Cremieux CP5706, 91057 Evry, Group Oncoproteins, Unité CNRS-UDS UMR 7242, Institut de Recherche de l'Ecole de Biotechnologie de Strasbourg, 1, Bd Sébastien Brant, BP 10413, 67412 Illkirch - Cedex, France, Biocomputing Group, Department of Physics, Sapienza University of Rome, P.le Aldo Moro 5, Rome, Italy, School of Biological Sciences, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, UK, School of Medicine and Medical Science, University College, Dublin, Ireland, Centre for Biological Sciences, Institute for Life Sciences, University of Southampton, UK, Biomolecular Research, Paul Scherrer Institut, CH-5232 Villigen PSI, Switzerland, Bioinformatik, Institut für Biochemie, Friedrich-Alexander-Universität, Fahrstraße 17, 91054 Erlangen-Nürnberg and Molecular Health GmbH Belfortstr. 2, 69115 Heidelberg, Germany
    • Toedt, Grischa. Structural and Computational Biology, European Molecular Biology Laboratory, Heidelberg, Germany, Laboratory of Bioinformatics and Systems Biology, M. Sklodowska-Curie Cancer Center and Institute of Oncology, WK Roentgena 5, 02-781 Warsaw, Poland, Genoscope (CEA - Institut de Génomique), 2 rue Gaston Cremieux CP5706, 91057 Evry, Group Oncoproteins, Unité CNRS-UDS UMR 7242, Institut de Recherche de l'Ecole de Biotechnologie de Strasbourg, 1, Bd Sébastien Brant, BP 10413, 67412 Illkirch - Cedex, France, Biocomputing Group, Department of Physics, Sapienza University of Rome, P.le Aldo Moro 5, Rome, Italy, School of Biological Sciences, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, UK, School of Medicine and Medical Science, University College, Dublin, Ireland, Centre for Biological Sciences, Institute for Life Sciences, University of Southampton, UK, Biomolecular Research, Paul Scherrer Institut, CH-5232 Villigen PSI, Switzerland, Bioinformatik, Institut für Biochemie, Friedrich-Alexander-Universität, Fahrstraße 17, 91054 Erlangen-Nürnberg and Molecular Health GmbH Belfortstr. 2, 69115 Heidelberg, Germany
    • Uyar, Bora. Structural and Computational Biology, European Molecular Biology Laboratory, Heidelberg, Germany, Laboratory of Bioinformatics and Systems Biology, M. Sklodowska-Curie Cancer Center and Institute of Oncology, WK Roentgena 5, 02-781 Warsaw, Poland, Genoscope (CEA - Institut de Génomique), 2 rue Gaston Cremieux CP5706, 91057 Evry, Group Oncoproteins, Unité CNRS-UDS UMR 7242, Institut de Recherche de l'Ecole de Biotechnologie de Strasbourg, 1, Bd Sébastien Brant, BP 10413, 67412 Illkirch - Cedex, France, Biocomputing Group, Department of Physics, Sapienza University of Rome, P.le Aldo Moro 5, Rome, Italy, School of Biological Sciences, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, UK, School of Medicine and Medical Science, University College, Dublin, Ireland, Centre for Biological Sciences, Institute for Life Sciences, University of Southampton, UK, Biomolecular Research, Paul Scherrer Institut, CH-5232 Villigen PSI, Switzerland, Bioinformatik, Institut für Biochemie, Friedrich-Alexander-Universität, Fahrstraße 17, 91054 Erlangen-Nürnberg and Molecular Health GmbH Belfortstr. 2, 69115 Heidelberg, Germany
    • Seiler, Markus. Structural and Computational Biology, European Molecular Biology Laboratory, Heidelberg, Germany, Laboratory of Bioinformatics and Systems Biology, M. Sklodowska-Curie Cancer Center and Institute of Oncology, WK Roentgena 5, 02-781 Warsaw, Poland, Genoscope (CEA - Institut de Génomique), 2 rue Gaston Cremieux CP5706, 91057 Evry, Group Oncoproteins, Unité CNRS-UDS UMR 7242, Institut de Recherche de l'Ecole de Biotechnologie de Strasbourg, 1, Bd Sébastien Brant, BP 10413, 67412 Illkirch - Cedex, France, Biocomputing Group, Department of Physics, Sapienza University of Rome, P.le Aldo Moro 5, Rome, Italy, School of Biological Sciences, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, UK, School of Medicine and Medical Science, University College, Dublin, Ireland, Centre for Biological Sciences, Institute for Life Sciences, University of Southampton, UK, Biomolecular Research, Paul Scherrer Institut, CH-5232 Villigen PSI, Switzerland, Bioinformatik, Institut für Biochemie, Friedrich-Alexander-Universität, Fahrstraße 17, 91054 Erlangen-Nürnberg and Molecular Health GmbH Belfortstr. 2, 69115 Heidelberg, Germany
    • Budd, Aidan. Structural and Computational Biology, European Molecular Biology Laboratory, Heidelberg, Germany, Laboratory of Bioinformatics and Systems Biology, M. Sklodowska-Curie Cancer Center and Institute of Oncology, WK Roentgena 5, 02-781 Warsaw, Poland, Genoscope (CEA - Institut de Génomique), 2 rue Gaston Cremieux CP5706, 91057 Evry, Group Oncoproteins, Unité CNRS-UDS UMR 7242, Institut de Recherche de l'Ecole de Biotechnologie de Strasbourg, 1, Bd Sébastien Brant, BP 10413, 67412 Illkirch - Cedex, France, Biocomputing Group, Department of Physics, Sapienza University of Rome, P.le Aldo Moro 5, Rome, Italy, School of Biological Sciences, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, UK, School of Medicine and Medical Science, University College, Dublin, Ireland, Centre for Biological Sciences, Institute for Life Sciences, University of Southampton, UK, Biomolecular Research, Paul Scherrer Institut, CH-5232 Villigen PSI, Switzerland, Bioinformatik, Institut für Biochemie, Friedrich-Alexander-Universität, Fahrstraße 17, 91054 Erlangen-Nürnberg and Molecular Health GmbH Belfortstr. 2, 69115 Heidelberg, Germany
    • Jödicke, Lisa. Structural and Computational Biology, European Molecular Biology Laboratory, Heidelberg, Germany, Laboratory of Bioinformatics and Systems Biology, M. Sklodowska-Curie Cancer Center and Institute of Oncology, WK Roentgena 5, 02-781 Warsaw, Poland, Genoscope (CEA - Institut de Génomique), 2 rue Gaston Cremieux CP5706, 91057 Evry, Group Oncoproteins, Unité CNRS-UDS UMR 7242, Institut de Recherche de l'Ecole de Biotechnologie de Strasbourg, 1, Bd Sébastien Brant, BP 10413, 67412 Illkirch - Cedex, France, Biocomputing Group, Department of Physics, Sapienza University of Rome, P.le Aldo Moro 5, Rome, Italy, School of Biological Sciences, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, UK, School of Medicine and Medical Science, University College, Dublin, Ireland, Centre for Biological Sciences, Institute for Life Sciences, University of Southampton, UK, Biomolecular Research, Paul Scherrer Institut, CH-5232 Villigen PSI, Switzerland, Bioinformatik, Institut für Biochemie, Friedrich-Alexander-Universität, Fahrstraße 17, 91054 Erlangen-Nürnberg and Molecular Health GmbH Belfortstr. 2, 69115 Heidelberg, Germany
    • Dammert, Marcel A.. Structural and Computational Biology, European Molecular Biology Laboratory, Heidelberg, Germany, Laboratory of Bioinformatics and Systems Biology, M. Sklodowska-Curie Cancer Center and Institute of Oncology, WK Roentgena 5, 02-781 Warsaw, Poland, Genoscope (CEA - Institut de Génomique), 2 rue Gaston Cremieux CP5706, 91057 Evry, Group Oncoproteins, Unité CNRS-UDS UMR 7242, Institut de Recherche de l'Ecole de Biotechnologie de Strasbourg, 1, Bd Sébastien Brant, BP 10413, 67412 Illkirch - Cedex, France, Biocomputing Group, Department of Physics, Sapienza University of Rome, P.le Aldo Moro 5, Rome, Italy, School of Biological Sciences, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, UK, School of Medicine and Medical Science, University College, Dublin, Ireland, Centre for Biological Sciences, Institute for Life Sciences, University of Southampton, UK, Biomolecular Research, Paul Scherrer Institut, CH-5232 Villigen PSI, Switzerland, Bioinformatik, Institut für Biochemie, Friedrich-Alexander-Universität, Fahrstraße 17, 91054 Erlangen-Nürnberg and Molecular Health GmbH Belfortstr. 2, 69115 Heidelberg, Germany
    • Schroeter, Christian. Structural and Computational Biology, European Molecular Biology Laboratory, Heidelberg, Germany, Laboratory of Bioinformatics and Systems Biology, M. Sklodowska-Curie Cancer Center and Institute of Oncology, WK Roentgena 5, 02-781 Warsaw, Poland, Genoscope (CEA - Institut de Génomique), 2 rue Gaston Cremieux CP5706, 91057 Evry, Group Oncoproteins, Unité CNRS-UDS UMR 7242, Institut de Recherche de l'Ecole de Biotechnologie de Strasbourg, 1, Bd Sébastien Brant, BP 10413, 67412 Illkirch - Cedex, France, Biocomputing Group, Department of Physics, Sapienza University of Rome, P.le Aldo Moro 5, Rome, Italy, School of Biological Sciences, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, UK, School of Medicine and Medical Science, University College, Dublin, Ireland, Centre for Biological Sciences, Institute for Life Sciences, University of Southampton, UK, Biomolecular Research, Paul Scherrer Institut, CH-5232 Villigen PSI, Switzerland, Bioinformatik, Institut für Biochemie, Friedrich-Alexander-Universität, Fahrstraße 17, 91054 Erlangen-Nürnberg and Molecular Health GmbH Belfortstr. 2, 69115 Heidelberg, Germany
    • Hammer, Maria. Structural and Computational Biology, European Molecular Biology Laboratory, Heidelberg, Germany, Laboratory of Bioinformatics and Systems Biology, M. Sklodowska-Curie Cancer Center and Institute of Oncology, WK Roentgena 5, 02-781 Warsaw, Poland, Genoscope (CEA - Institut de Génomique), 2 rue Gaston Cremieux CP5706, 91057 Evry, Group Oncoproteins, Unité CNRS-UDS UMR 7242, Institut de Recherche de l'Ecole de Biotechnologie de Strasbourg, 1, Bd Sébastien Brant, BP 10413, 67412 Illkirch - Cedex, France, Biocomputing Group, Department of Physics, Sapienza University of Rome, P.le Aldo Moro 5, Rome, Italy, School of Biological Sciences, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, UK, School of Medicine and Medical Science, University College, Dublin, Ireland, Centre for Biological Sciences, Institute for Life Sciences, University of Southampton, UK, Biomolecular Research, Paul Scherrer Institut, CH-5232 Villigen PSI, Switzerland, Bioinformatik, Institut für Biochemie, Friedrich-Alexander-Universität, Fahrstraße 17, 91054 Erlangen-Nürnberg and Molecular Health GmbH Belfortstr. 2, 69115 Heidelberg, Germany
    • Schmidt, Tobias. Structural and Computational Biology, European Molecular Biology Laboratory, Heidelberg, Germany, Laboratory of Bioinformatics and Systems Biology, M. Sklodowska-Curie Cancer Center and Institute of Oncology, WK Roentgena 5, 02-781 Warsaw, Poland, Genoscope (CEA - Institut de Génomique), 2 rue Gaston Cremieux CP5706, 91057 Evry, Group Oncoproteins, Unité CNRS-UDS UMR 7242, Institut de Recherche de l'Ecole de Biotechnologie de Strasbourg, 1, Bd Sébastien Brant, BP 10413, 67412 Illkirch - Cedex, France, Biocomputing Group, Department of Physics, Sapienza University of Rome, P.le Aldo Moro 5, Rome, Italy, School of Biological Sciences, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, UK, School of Medicine and Medical Science, University College, Dublin, Ireland, Centre for Biological Sciences, Institute for Life Sciences, University of Southampton, UK, Biomolecular Research, Paul Scherrer Institut, CH-5232 Villigen PSI, Switzerland, Bioinformatik, Institut für Biochemie, Friedrich-Alexander-Universität, Fahrstraße 17, 91054 Erlangen-Nürnberg and Molecular Health GmbH Belfortstr. 2, 69115 Heidelberg, Germany
    • Jehl, Peter. Structural and Computational Biology, European Molecular Biology Laboratory, Heidelberg, Germany, Laboratory of Bioinformatics and Systems Biology, M. Sklodowska-Curie Cancer Center and Institute of Oncology, WK Roentgena 5, 02-781 Warsaw, Poland, Genoscope (CEA - Institut de Génomique), 2 rue Gaston Cremieux CP5706, 91057 Evry, Group Oncoproteins, Unité CNRS-UDS UMR 7242, Institut de Recherche de l'Ecole de Biotechnologie de Strasbourg, 1, Bd Sébastien Brant, BP 10413, 67412 Illkirch - Cedex, France, Biocomputing Group, Department of Physics, Sapienza University of Rome, P.le Aldo Moro 5, Rome, Italy, School of Biological Sciences, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, UK, School of Medicine and Medical Science, University College, Dublin, Ireland, Centre for Biological Sciences, Institute for Life Sciences, University of Southampton, UK, Biomolecular Research, Paul Scherrer Institut, CH-5232 Villigen PSI, Switzerland, Bioinformatik, Institut für Biochemie, Friedrich-Alexander-Universität, Fahrstraße 17, 91054 Erlangen-Nürnberg and Molecular Health GmbH Belfortstr. 2, 69115 Heidelberg, Germany
    • McGuigan, Caroline. Structural and Computational Biology, European Molecular Biology Laboratory, Heidelberg, Germany, Laboratory of Bioinformatics and Systems Biology, M. Sklodowska-Curie Cancer Center and Institute of Oncology, WK Roentgena 5, 02-781 Warsaw, Poland, Genoscope (CEA - Institut de Génomique), 2 rue Gaston Cremieux CP5706, 91057 Evry, Group Oncoproteins, Unité CNRS-UDS UMR 7242, Institut de Recherche de l'Ecole de Biotechnologie de Strasbourg, 1, Bd Sébastien Brant, BP 10413, 67412 Illkirch - Cedex, France, Biocomputing Group, Department of Physics, Sapienza University of Rome, P.le Aldo Moro 5, Rome, Italy, School of Biological Sciences, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, UK, School of Medicine and Medical Science, University College, Dublin, Ireland, Centre for Biological Sciences, Institute for Life Sciences, University of Southampton, UK, Biomolecular Research, Paul Scherrer Institut, CH-5232 Villigen PSI, Switzerland, Bioinformatik, Institut für Biochemie, Friedrich-Alexander-Universität, Fahrstraße 17, 91054 Erlangen-Nürnberg and Molecular Health GmbH Belfortstr. 2, 69115 Heidelberg, Germany
    • Dymecka, Magdalena. Structural and Computational Biology, European Molecular Biology Laboratory, Heidelberg, Germany, Laboratory of Bioinformatics and Systems Biology, M. Sklodowska-Curie Cancer Center and Institute of Oncology, WK Roentgena 5, 02-781 Warsaw, Poland, Genoscope (CEA - Institut de Génomique), 2 rue Gaston Cremieux CP5706, 91057 Evry, Group Oncoproteins, Unité CNRS-UDS UMR 7242, Institut de Recherche de l'Ecole de Biotechnologie de Strasbourg, 1, Bd Sébastien Brant, BP 10413, 67412 Illkirch - Cedex, France, Biocomputing Group, Department of Physics, Sapienza University of Rome, P.le Aldo Moro 5, Rome, Italy, School of Biological Sciences, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, UK, School of Medicine and Medical Science, University College, Dublin, Ireland, Centre for Biological Sciences, Institute for Life Sciences, University of Southampton, UK, Biomolecular Research, Paul Scherrer Institut, CH-5232 Villigen PSI, Switzerland, Bioinformatik, Institut für Biochemie, Friedrich-Alexander-Universität, Fahrstraße 17, 91054 Erlangen-Nürnberg and Molecular Health GmbH Belfortstr. 2, 69115 Heidelberg, Germany
    • Chica, Claudia. Structural and Computational Biology, European Molecular Biology Laboratory, Heidelberg, Germany, Laboratory of Bioinformatics and Systems Biology, M. Sklodowska-Curie Cancer Center and Institute of Oncology, WK Roentgena 5, 02-781 Warsaw, Poland, Genoscope (CEA - Institut de Génomique), 2 rue Gaston Cremieux CP5706, 91057 Evry, Group Oncoproteins, Unité CNRS-UDS UMR 7242, Institut de Recherche de l'Ecole de Biotechnologie de Strasbourg, 1, Bd Sébastien Brant, BP 10413, 67412 Illkirch - Cedex, France, Biocomputing Group, Department of Physics, Sapienza University of Rome, P.le Aldo Moro 5, Rome, Italy, School of Biological Sciences, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, UK, School of Medicine and Medical Science, University College, Dublin, Ireland, Centre for Biological Sciences, Institute for Life Sciences, University of Southampton, UK, Biomolecular Research, Paul Scherrer Institut, CH-5232 Villigen PSI, Switzerland, Bioinformatik, Institut für Biochemie, Friedrich-Alexander-Universität, Fahrstraße 17, 91054 Erlangen-Nürnberg and Molecular Health GmbH Belfortstr. 2, 69115 Heidelberg, Germany
    • Luck, Katja. Structural and Computational Biology, European Molecular Biology Laboratory, Heidelberg, Germany, Laboratory of Bioinformatics and Systems Biology, M. Sklodowska-Curie Cancer Center and Institute of Oncology, WK Roentgena 5, 02-781 Warsaw, Poland, Genoscope (CEA - Institut de Génomique), 2 rue Gaston Cremieux CP5706, 91057 Evry, Group Oncoproteins, Unité CNRS-UDS UMR 7242, Institut de Recherche de l'Ecole de Biotechnologie de Strasbourg, 1, Bd Sébastien Brant, BP 10413, 67412 Illkirch - Cedex, France, Biocomputing Group, Department of Physics, Sapienza University of Rome, P.le Aldo Moro 5, Rome, Italy, School of Biological Sciences, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, UK, School of Medicine and Medical Science, University College, Dublin, Ireland, Centre for Biological Sciences, Institute for Life Sciences, University of Southampton, UK, Biomolecular Research, Paul Scherrer Institut, CH-5232 Villigen PSI, Switzerland, Bioinformatik, Institut für Biochemie, Friedrich-Alexander-Universität, Fahrstraße 17, 91054 Erlangen-Nürnberg and Molecular Health GmbH Belfortstr. 2, 69115 Heidelberg, Germany
    • Via, Allegra. Structural and Computational Biology, European Molecular Biology Laboratory, Heidelberg, Germany, Laboratory of Bioinformatics and Systems Biology, M. Sklodowska-Curie Cancer Center and Institute of Oncology, WK Roentgena 5, 02-781 Warsaw, Poland, Genoscope (CEA - Institut de Génomique), 2 rue Gaston Cremieux CP5706, 91057 Evry, Group Oncoproteins, Unité CNRS-UDS UMR 7242, Institut de Recherche de l'Ecole de Biotechnologie de Strasbourg, 1, Bd Sébastien Brant, BP 10413, 67412 Illkirch - Cedex, France, Biocomputing Group, Department of Physics, Sapienza University of Rome, P.le Aldo Moro 5, Rome, Italy, School of Biological Sciences, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, UK, School of Medicine and Medical Science, University College, Dublin, Ireland, Centre for Biological Sciences, Institute for Life Sciences, University of Southampton, UK, Biomolecular Research, Paul Scherrer Institut, CH-5232 Villigen PSI, Switzerland, Bioinformatik, Institut für Biochemie, Friedrich-Alexander-Universität, Fahrstraße 17, 91054 Erlangen-Nürnberg and Molecular Health GmbH Belfortstr. 2, 69115 Heidelberg, Germany
    • Chatr-aryamontri, Andrew. Structural and Computational Biology, European Molecular Biology Laboratory, Heidelberg, Germany, Laboratory of Bioinformatics and Systems Biology, M. Sklodowska-Curie Cancer Center and Institute of Oncology, WK Roentgena 5, 02-781 Warsaw, Poland, Genoscope (CEA - Institut de Génomique), 2 rue Gaston Cremieux CP5706, 91057 Evry, Group Oncoproteins, Unité CNRS-UDS UMR 7242, Institut de Recherche de l'Ecole de Biotechnologie de Strasbourg, 1, Bd Sébastien Brant, BP 10413, 67412 Illkirch - Cedex, France, Biocomputing Group, Department of Physics, Sapienza University of Rome, P.le Aldo Moro 5, Rome, Italy, School of Biological Sciences, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, UK, School of Medicine and Medical Science, University College, Dublin, Ireland, Centre for Biological Sciences, Institute for Life Sciences, University of Southampton, UK, Biomolecular Research, Paul Scherrer Institut, CH-5232 Villigen PSI, Switzerland, Bioinformatik, Institut für Biochemie, Friedrich-Alexander-Universität, Fahrstraße 17, 91054 Erlangen-Nürnberg and Molecular Health GmbH Belfortstr. 2, 69115 Heidelberg, Germany
    • Haslam, Niall. Structural and Computational Biology, European Molecular Biology Laboratory, Heidelberg, Germany, Laboratory of Bioinformatics and Systems Biology, M. Sklodowska-Curie Cancer Center and Institute of Oncology, WK Roentgena 5, 02-781 Warsaw, Poland, Genoscope (CEA - Institut de Génomique), 2 rue Gaston Cremieux CP5706, 91057 Evry, Group Oncoproteins, Unité CNRS-UDS UMR 7242, Institut de Recherche de l'Ecole de Biotechnologie de Strasbourg, 1, Bd Sébastien Brant, BP 10413, 67412 Illkirch - Cedex, France, Biocomputing Group, Department of Physics, Sapienza University of Rome, P.le Aldo Moro 5, Rome, Italy, School of Biological Sciences, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, UK, School of Medicine and Medical Science, University College, Dublin, Ireland, Centre for Biological Sciences, Institute for Life Sciences, University of Southampton, UK, Biomolecular Research, Paul Scherrer Institut, CH-5232 Villigen PSI, Switzerland, Bioinformatik, Institut für Biochemie, Friedrich-Alexander-Universität, Fahrstraße 17, 91054 Erlangen-Nürnberg and Molecular Health GmbH Belfortstr. 2, 69115 Heidelberg, Germany
    • Grebnev, Gleb. Structural and Computational Biology, European Molecular Biology Laboratory, Heidelberg, Germany, Laboratory of Bioinformatics and Systems Biology, M. Sklodowska-Curie Cancer Center and Institute of Oncology, WK Roentgena 5, 02-781 Warsaw, Poland, Genoscope (CEA - Institut de Génomique), 2 rue Gaston Cremieux CP5706, 91057 Evry, Group Oncoproteins, Unité CNRS-UDS UMR 7242, Institut de Recherche de l'Ecole de Biotechnologie de Strasbourg, 1, Bd Sébastien Brant, BP 10413, 67412 Illkirch - Cedex, France, Biocomputing Group, Department of Physics, Sapienza University of Rome, P.le Aldo Moro 5, Rome, Italy, School of Biological Sciences, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, UK, School of Medicine and Medical Science, University College, Dublin, Ireland, Centre for Biological Sciences, Institute for Life Sciences, University of Southampton, UK, Biomolecular Research, Paul Scherrer Institut, CH-5232 Villigen PSI, Switzerland, Bioinformatik, Institut für Biochemie, Friedrich-Alexander-Universität, Fahrstraße 17, 91054 Erlangen-Nürnberg and Molecular Health GmbH Belfortstr. 2, 69115 Heidelberg, Germany
    • Edwards, Richard J.. Structural and Computational Biology, European Molecular Biology Laboratory, Heidelberg, Germany, Laboratory of Bioinformatics and Systems Biology, M. Sklodowska-Curie Cancer Center and Institute of Oncology, WK Roentgena 5, 02-781 Warsaw, Poland, Genoscope (CEA - Institut de Génomique), 2 rue Gaston Cremieux CP5706, 91057 Evry, Group Oncoproteins, Unité CNRS-UDS UMR 7242, Institut de Recherche de l'Ecole de Biotechnologie de Strasbourg, 1, Bd Sébastien Brant, BP 10413, 67412 Illkirch - Cedex, France, Biocomputing Group, Department of Physics, Sapienza University of Rome, P.le Aldo Moro 5, Rome, Italy, School of Biological Sciences, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, UK, School of Medicine and Medical Science, University College, Dublin, Ireland, Centre for Biological Sciences, Institute for Life Sciences, University of Southampton, UK, Biomolecular Research, Paul Scherrer Institut, CH-5232 Villigen PSI, Switzerland, Bioinformatik, Institut für Biochemie, Friedrich-Alexander-Universität, Fahrstraße 17, 91054 Erlangen-Nürnberg and Molecular Health GmbH Belfortstr. 2, 69115 Heidelberg, Germany
    • Steinmetz, Michel O.. Structural and Computational Biology, European Molecular Biology Laboratory, Heidelberg, Germany, Laboratory of Bioinformatics and Systems Biology, M. Sklodowska-Curie Cancer Center and Institute of Oncology, WK Roentgena 5, 02-781 Warsaw, Poland, Genoscope (CEA - Institut de Génomique), 2 rue Gaston Cremieux CP5706, 91057 Evry, Group Oncoproteins, Unité CNRS-UDS UMR 7242, Institut de Recherche de l'Ecole de Biotechnologie de Strasbourg, 1, Bd Sébastien Brant, BP 10413, 67412 Illkirch - Cedex, France, Biocomputing Group, Department of Physics, Sapienza University of Rome, P.le Aldo Moro 5, Rome, Italy, School of Biological Sciences, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, UK, School of Medicine and Medical Science, University College, Dublin, Ireland, Centre for Biological Sciences, Institute for Life Sciences, University of Southampton, UK, Biomolecular Research, Paul Scherrer Institut, CH-5232 Villigen PSI, Switzerland, Bioinformatik, Institut für Biochemie, Friedrich-Alexander-Universität, Fahrstraße 17, 91054 Erlangen-Nürnberg and Molecular Health GmbH Belfortstr. 2, 69115 Heidelberg, Germany
    • Meiselbach, Heike. Structural and Computational Biology, European Molecular Biology Laboratory, Heidelberg, Germany, Laboratory of Bioinformatics and Systems Biology, M. Sklodowska-Curie Cancer Center and Institute of Oncology, WK Roentgena 5, 02-781 Warsaw, Poland, Genoscope (CEA - Institut de Génomique), 2 rue Gaston Cremieux CP5706, 91057 Evry, Group Oncoproteins, Unité CNRS-UDS UMR 7242, Institut de Recherche de l'Ecole de Biotechnologie de Strasbourg, 1, Bd Sébastien Brant, BP 10413, 67412 Illkirch - Cedex, France, Biocomputing Group, Department of Physics, Sapienza University of Rome, P.le Aldo Moro 5, Rome, Italy, School of Biological Sciences, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, UK, School of Medicine and Medical Science, University College, Dublin, Ireland, Centre for Biological Sciences, Institute for Life Sciences, University of Southampton, UK, Biomolecular Research, Paul Scherrer Institut, CH-5232 Villigen PSI, Switzerland, Bioinformatik, Institut für Biochemie, Friedrich-Alexander-Universität, Fahrstraße 17, 91054 Erlangen-Nürnberg and Molecular Health GmbH Belfortstr. 2, 69115 Heidelberg, Germany
    • Diella, Francesca. Structural and Computational Biology, European Molecular Biology Laboratory, Heidelberg, Germany, Laboratory of Bioinformatics and Systems Biology, M. Sklodowska-Curie Cancer Center and Institute of Oncology, WK Roentgena 5, 02-781 Warsaw, Poland, Genoscope (CEA - Institut de Génomique), 2 rue Gaston Cremieux CP5706, 91057 Evry, Group Oncoproteins, Unité CNRS-UDS UMR 7242, Institut de Recherche de l'Ecole de Biotechnologie de Strasbourg, 1, Bd Sébastien Brant, BP 10413, 67412 Illkirch - Cedex, France, Biocomputing Group, Department of Physics, Sapienza University of Rome, P.le Aldo Moro 5, Rome, Italy, School of Biological Sciences, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, UK, School of Medicine and Medical Science, University College, Dublin, Ireland, Centre for Biological Sciences, Institute for Life Sciences, University of Southampton, UK, Biomolecular Research, Paul Scherrer Institut, CH-5232 Villigen PSI, Switzerland, Bioinformatik, Institut für Biochemie, Friedrich-Alexander-Universität, Fahrstraße 17, 91054 Erlangen-Nürnberg and Molecular Health GmbH Belfortstr. 2, 69115 Heidelberg, Germany
    • Gibson, Toby J.. Structural and Computational Biology, European Molecular Biology Laboratory, Heidelberg, Germany, Laboratory of Bioinformatics and Systems Biology, M. Sklodowska-Curie Cancer Center and Institute of Oncology, WK Roentgena 5, 02-781 Warsaw, Poland, Genoscope (CEA - Institut de Génomique), 2 rue Gaston Cremieux CP5706, 91057 Evry, Group Oncoproteins, Unité CNRS-UDS UMR 7242, Institut de Recherche de l'Ecole de Biotechnologie de Strasbourg, 1, Bd Sébastien Brant, BP 10413, 67412 Illkirch - Cedex, France, Biocomputing Group, Department of Physics, Sapienza University of Rome, P.le Aldo Moro 5, Rome, Italy, School of Biological Sciences, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, UK, School of Medicine and Medical Science, University College, Dublin, Ireland, Centre for Biological Sciences, Institute for Life Sciences, University of Southampton, UK, Biomolecular Research, Paul Scherrer Institut, CH-5232 Villigen PSI, Switzerland, Bioinformatik, Institut für Biochemie, Friedrich-Alexander-Universität, Fahrstraße 17, 91054 Erlangen-Nürnberg and Molecular Health GmbH Belfortstr. 2, 69115 Heidelberg, Germany
    Document Type
    • Postprint
    Language
    • English
    Published in
    • Nucleic Acids Research, 2012, vol. 40, no. D1, p. D242-D251. Oxford University Press
    Other Version
    Classification
    • Health
    Keywords
    OAI-PMH Identifier
    • oai:doc.rero.ch:293815
    Summary
    Linear motifs are short, evolutionarily plastic components of regulatory proteins and provide low-affinity interaction interfaces. These compact modules play central roles in mediating every aspect of the regulatory functionality of the cell. They are particularly prominent in mediating cell signaling, controlling protein turnover and directing protein localization. Given their importance, our understanding of motifs is surprisingly limited, largely as a result of the difficulty of discovery, both experimentally and computationally. The Eukaryotic Linear Motif (ELM) resource at http://elm.eu.org provides the biological community with a comprehensive database of known experimentally validated motifs, and an exploratory tool to discover putative linear motifs in user-submitted protein sequences. The current update of the ELM database comprises 1800 annotated motif instances representing 170 distinct functional classes, including approximately 500 novel instances and 24 novel classes. Several older motif class entries have been also revisited, improving annotation and adding novel instances. Furthermore, addition of full-text search capabilities, an enhanced interface and simplified batch download has improved the overall accessibility of the ELM data. The motif discovery portion of the ELM resource has added conservation, and structural attributes have been incorporated to aid users to discriminate biologically relevant motifs from stochastically occurring non-functional instances