Lipid Profiles in HIV-Infected Patients Receiving Combination Antiretroviral Therapy: Are Different Antiretroviral Drugs Associated with Different Lipid Profiles?
Fontas, E. ; van Leth, F. ; Sabin, C. A. ; Friis-Møller, N. ; Rickenbach, M. ; d'Arminio Monforte, A. ; Kirk, O. ; Dupon, M. ; Morfeldt, L. ; Mateu, S. ; Petoumenos, K. ; El-Sadr, W. ; de Wit, S. ; Lundgren, J. D. ; Pradier, C. ; Reiss, P.
In: The Journal of Infectious Diseases, 2004, vol. 189, no. 6, p. 1056-1074
Aggiungi alla tua lista- Summary
- Levels of triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c), and high-density lipoprotein cholesterol (HDL-c), as well as the TC:HDL-c ratio, were compared in patients receiving different antiretroviral therapy regimens. Patients receiving first-line regimens including protease inhibitors (PIs) had higher TC and TG levels and TC:HDL-c ratios than did antiretroviral-naive patients; patients receiving 2 PIs had higher levels of each lipid. Ritonavir-containing regimens were associated with higher TC and TG levels and TC:HDL-c ratios than were indinavir-containing regimens; however, receipt of nelfinavir was associated with reduced risk of lower HDL-c levels, and receipt of saquinavir was associated with lower TC:HDL-c ratios. Patients receiving nonnucleoside reverse-transcriptase inhibitors had higher levels of TC and LDL-c than did antiretroviral-naive patients, although the risk of having lower HDL-c levels was lower than that in patients receiving a single PI. Efavirenz was associated with higher levels of TC and TG than was nevirapine