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Antiplasmodial activity of a series of 1,3,5-triazine-substituted polyamines

Klenke, Burkhard ; Barrett, Michael P. ; Brun, Reto ; Gilbert, Ian H.

In: Journal of Antimicrobial Chemotherapy, 2003, vol. 52, no. 2, p. 290-293

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    Titre
    • Antiplasmodial activity of a series of 1,3,5-triazine-substituted polyamines
    Auteur
    • Klenke, Burkhard. Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff CF10 3XF
    • Barrett, Michael P.. Institute of Biomedical and Life Sciences, Division of Infection and Immunity, University of Glasgow, Glasgow G12 8QQ, UK
    • Brun, Reto. Swiss Tropical Institute, Socinstrasse 57, CH-4002 Basel, Switzerland
    • Gilbert, Ian H.. Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff CF10 3XF
    Type de document
    • Postprint
    Langue
    • Inglese
    Publié dans
    • Journal of Antimicrobial Chemotherapy, 2003, vol. 52, no. 2, p. 290-293. Oxford University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:293541
    Summary
    Polyamine biosynthesis and function has been shown to be a good drug target in some parasitic protozoa and it is proposed that the pathway might also represent a target in the malaria parasite Plasmodium falciparum. A series of 1,3,5-triazine-substituted polyamine analogues were tested for activity against Plasmodium falciparum in vitro. The series showed activity against the parasites and were generally more active against the chloroquine-resistant line K1 than the chloroquine-susceptible line NF54. Simple unbranched analogues had better activity than analogues carrying branched or cyclic central chains. Addition of multiple triazine units in general led to increased activity of the compounds