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PREOPERATIVE SEDATION BEFORE REGIONAL ANAESTHESIA: COMPARISON BETWEEN ZOLPIDEM, MIDAZOLAM AND PLACEBO

PRAPLAN-PAHUD, J. ; FORSTER, A. ; GAMULIN, Z. ; TASSONYI, E. ; SAUVANET, J.-P

In: BJA: British Journal of Anaesthesia, 1990, vol. 64, no. 6, p. 670-674

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    Titre
    • PREOPERATIVE SEDATION BEFORE REGIONAL ANAESTHESIA: COMPARISON BETWEEN ZOLPIDEM, MIDAZOLAM AND PLACEBO
    Auteur
    • PRAPLAN-PAHUD, J.. Department of Anaesthesiology, University Hospital of Geneva 1211 Geneve 4, Switzerland
    • FORSTER, A.. Department of Anaesthesiology, University Hospital of Geneva 1211 Geneve 4, Switzerland
    • GAMULIN, Z.. Department of Anaesthesiology, University Hospital of Geneva 1211 Geneve 4, Switzerland
    • TASSONYI, E.. Department of Anaesthesiology, University Hospital of Geneva 1211 Geneve 4, Switzerland
    • SAUVANET, J.-P. LERS Synthelabo Paris, France
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • BJA: British Journal of Anaesthesia, 1990, vol. 64, no. 6, p. 670-674. Oxford University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:293368
    Summary
    The quality of premedication induced by oral midazolam and zolpidem, a new imidazopyridine hypnotic, was assessed in a controlled, double-blind study in 93 patients undergoing elective surgery under spinal or extradural anaesthesia. The patients were allocated randomly to three groups. Each group received the same treatment twice at two different doses. The night before operation, patients received zolpidem 10 mg, midazolam 7.5 mg or placebo and, 1 h before operation, zolpidem 20 mg, midazolam 15 mg or placebo. The sleep inducing effects of the drugs were comparable. Zolpidem and midazolam were significantly more effective sedatives than placebo 45 min after administration, but no difference was noted between the drugs. There was a comparable incidence of anterograde amnesia with zolpidem and midazolam, but the onset was shorter after zolpidem. Side effects were comparable in the three groups. Zolpidem is an effective hypnotic with a rapid onset and short duration of action which may be an alternative to midazolam for premedication